Selenium supplementation for critically ill adults

Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children

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Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children

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Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial

“…However, daily doses of selenium and vitamin C were even below the currently recommended dietary allowances (RDA) of 55 and 80 mg/day, respectively, and the 10 mg/day of zinc just equalled current RDA. Hence, these doses were much lower than those commonly used in clinical trials reporting positive effects on the immune response (11–14, 19, 25). Moreover, treatment was initiated after the onset of symptoms in which case none of the clinical trials has yet revealed any benefit from vitamin C (11, 12) and from zinc it was detectable only if started up to 1 day later (13, 14).…”

Selenium in Intensive Care (SIC): Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock*

“…However, due to low quality of data and no comparable supplementation regimens, a Cochrane analysis concluded, "There is insufficient evidence to recommend supplementation of critically ill patients with selenium or ebselen" (27). The results of this larger, multiple-centre trial now confirm the efficacy of highdose sodium-selenite supplementation in patients with severe sepsis and septic shock.…”

Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children

“……”

Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial

“…However, daily doses of selenium and vitamin C were even below the currently recommended dietary allowances (RDA) of 55 and 80 mg/day, respectively, and the 10 mg/day of zinc just equalled current RDA. Hence, these doses were much lower than those commonly used in clinical trials reporting positive effects on the immune response (11–14, 19, 25). Moreover, treatment was initiated after the onset of symptoms in which case none of the clinical trials has yet revealed any benefit from vitamin C (11, 12) and from zinc it was detectable only if started up to 1 day later (13, 14).…”

Selenium in Intensive Care (SIC): Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock*

“…However, due to low quality of data and no comparable supplementation regimens, a Cochrane analysis concluded, "There is insufficient evidence to recommend supplementation of critically ill patients with selenium or ebselen" (27). The results of this larger, multiple-centre trial now confirm the efficacy of highdose sodium-selenite supplementation in patients with severe sepsis and septic shock.…”

Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children

“……”

Echinacea purpurea along with zinc, selenium and vitamin C to alleviate exacerbations of chronic obstructive pulmonary disease: results from a randomized controlled trial

“…However, daily doses of selenium and vitamin C were even below the currently recommended dietary allowances (RDA) of 55 and 80 mg/day, respectively, and the 10 mg/day of zinc just equalled current RDA. Hence, these doses were much lower than those commonly used in clinical trials reporting positive effects on the immune response (11–14, 19, 25). Moreover, treatment was initiated after the onset of symptoms in which case none of the clinical trials has yet revealed any benefit from vitamin C (11, 12) and from zinc it was detectable only if started up to 1 day later (13, 14).…”

Selenium in Intensive Care (SIC): Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock*

“…However, due to low quality of data and no comparable supplementation regimens, a Cochrane analysis concluded, "There is insufficient evidence to recommend supplementation of critically ill patients with selenium or ebselen" (27). The results of this larger, multiple-centre trial now confirm the efficacy of highdose sodium-selenite supplementation in patients with severe sepsis and septic shock.…”