Selenium Status and the Risk of Esophageal and Gastric Cancer Subtypes: The Netherlands Cohort Study

Steevens, Jessie; Brandt, Piet A. van den; Goldbohm, R. Alexandra; Schouten, Leo J.

doi:10.1053/j.gastro.2009.12.004

Cited by 79 publications

(64 citation statements)

References 41 publications

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“…An inverse association between toenail selenium content and esophageal squamous cell carcinoma and gastric cardia carcinoma was observed (346). The multivariable adjusted RR for esophageal squamous cell carcinoma and gastric cancer were 0.37 (95% CI: 0.16-0.86) and 0.52 (95% CI: 0.27-1.02) respectively, for the highest quartile selenium status (toenail selenium >0.613 mg=g) compared with the lowest quartile (toenail selenium 0.498 mg=g) (346).…”

Section: Gastrointestinal Cancersmentioning

confidence: 87%

Selenium in Human Health and Disease

Fairweather‐Tait

Bao

Broadley

et al. 2011

Antioxidants & Redox Signaling

1,072

820

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This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.

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Section: Gastrointestinal Cancersmentioning

confidence: 87%

Selenium in Human Health and Disease

Fairweather‐Tait

Bao

Broadley

et al. 2011

Antioxidants & Redox Signaling

1,072

820

View full text Add to dashboard Cite

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“…A total of some 120,000 persons aged 55-69 years had their toenail clippings analyzed for selenium. Sixteen years later, 114 had developed gastric cancer and there was a borderline significant inverse relationship between selenium status and incidence of gastric cancer [17] .…”

Section: Dietary Factorsmentioning

confidence: 99%

Gastric Cancer: Epidemiology and Risk Factors

Krejs

2010

Dig Dis

132

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The incidence of gastric cancer is decreasing and lies between 10 and 15 new cases per 100,000 population per year in most Western countries. Peak age is between 60 and 80 years. While distal gastric cancers account for the overall decrease in gastric cancer, tumors in the proximal stomach (cardia and esophagogastric junction) are on the rise. Recognized risk factors for gastric cancer are infection with Helicobacter pylori, dietary factors (e.g. high intake of salt-preserved foods), smoking, pernicious anemia and a history of partial gastrectomy.

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“…Two case-control studies from Australia [28•] and Ireland [33] reported a 15-20% increased risk associated with selenium intake. However, results differed when toenail selenium concentrations were examined; the Irish case-control study found no association [39], and a Dutch case-cohort study reported a 24% decreased risk [40]. In a cohort study of BE patients that examined EA-related outcomes, EA risk was increased 40% in association with higher serum selenium concentrations [41].…”

Section: Antioxidants and Other Vitamins/mineralsmentioning

confidence: 99%

Dietary Risk Reduction Factors for the Barrett’s Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature

Petrick¹,

Li²,

McClain³

et al. 2014

Curr Nutr Rep

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Esophageal adenocarcinoma (EA) incidence is among the most rapidly increasing of any cancer type in the U.S., and prognosis is poor. Prevalence of the potential precursor lesion, Barrett's esophagus (BE), is also increasing. Candidates for safe and effective risk reduction strategies are needed, potentially including dietary components. In this qualitative review, we summarize recently published epidemiologic studies, in context of earlier work, on dietary intake and BE-EA outcomes. Potential cohort study/intervention trial candidates which could be increased to reduce BE-EA development include intake of: (1) fruits and vegetables; vegetables; fruit (EA only); (2) β-carotene and vitamins C and E; (3) folate (EA only); and (4) total fiber (EA only). Also, (5) red and processed meat intake could be targeted for dietary reduction/omission to reduce EA development. Few dietary constituents have been evaluated among EA patients to examine associations with mortality, thus interventions conducted among EA patients are premature.

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Selenium Status and the Risk of Esophageal and Gastric Cancer Subtypes: The Netherlands Cohort Study

Cited by 79 publications

References 41 publications

Selenium in Human Health and Disease

Selenium in Human Health and Disease

Gastric Cancer: Epidemiology and Risk Factors

Dietary Risk Reduction Factors for the Barrett’s Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature

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