Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation

Bozkurt, Selim; Arıkan, Deniz Cemgil; Kurutaş, Ergül Belge; Sayar, Hamide; Okumuş, Mehmet; Coşkun, Ayhan; Bakan, Vedat

doi:10.1016/j.jpedsurg.2012.03.053

Cited by 55 publications

(43 citation statements)

References 58 publications

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“…The administration of TQ lowered both the IL-6 and MDA production from the ovary, which reflects the tissue oxidative stress in the I/R groups. We noted that IL-6 and MDA concentrations were higher in the I/R groups than in the sham group and lower in the TQ groups than in the I/R groups in parallel to previous publications [3,7,8,30,32]. …”

Section: Discussionsupporting

confidence: 91%

“…The release of free oxygen radicals is critical for the occurrence of postischemic injury [6]. Neutrophils constitute a potential source of reactive oxygen species (ROS), and I/R injury can trigger adhesion and migration of circulating neutrophils to endothelial cells leading to the generation of ROS, which enhances neutrophil infiltration and results in ischemic injury [7]. Several anti-inflammatory and antioxidant free radical scavengers have been used to prevent such I/R injury in tissues [8].…”

Section: Introductionmentioning

confidence: 99%

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Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

Ural

Tekın²,

Şehitoğlu³

et al. 2015

Gynecol Obstet Invest

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Aim: To evaluate the antioxidant effects of thymoquinone (TQ) and to investigate the biochemical, histopathological and immunohistochemical changes in experimental rat ovarian torsion. Methods: A total of 48 female adult rats were used in this study and randomly divided into 7 groups: (1) sham operation; (2) bilateral 3-hour ovarian ischemia; (3) 3-hour ischemia and 3-hour reperfusion; (4) and (5) rats were administered 20 and 40 mg/kg of TQ, respectively, before 0.5 h of ischemia, and then 3 h of ovarian ischemia was applied; (6) and (7) 3-hour ovarian ischemia was applied; 2.5 h after the induction of ischemia, rats were administered the same doses of TQ; at the end of 3 h of ischemia, a 3-hour reperfusion was applied. Histologic changes under light microscopy, immunoreactivity for anticaspase-3 and serum levels ofmalondialdehyde, interleukin-6, catalase and glutathione peroxidase were noted and compared between the 7 groups. Results: Ischemia and ischemia/reperfusion cause a deterioration of biochemical and histopathological parameters. Administration of TQ seems to reverse these alterations and alleviate the injury. Antioxidant defense mechanisms appear to be enhanced by the administration of TQ. Conclusion: TQ at different doses attenuates ovarian ischemia and ischemia/reperfusion injury in rats.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

Ural

Tekın²,

Şehitoğlu³

et al. 2015

Gynecol Obstet Invest

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show abstract

“…29,40 In previous studies, when compared to control and/or sham groups, CAT, SOD and GR enzyme levels decreased or were inconclusive in almost all I/R models, including ovarian. 26,41 10 894 ± 1426 § 0213 ± 0062 ¶ 0018 ± 0007 § 3361 ± 0615 6 (3-6) ¶ (I/R) + EA (n = 7) 11 628 ± 1330 § 0210 ± 0022 ¶ 0019 ± 0,006 § 3144 ± 0603 § 3 (2-5) ¶, † † (I/R) + O + EA (n = 7) 11 744 ± 1344 § 0201 ± 0020 § 0016 ± 0006 § 2875 ± 0191 § 4 (2-4) ¶ †P < 0.001: statistically significant increase in the ischemia/reperfusion (I/R) compared with the control group. ‡P < 0.05: statistically significant increase in the I/R compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury

Sayar

Biçer

Gürsul

et al. 2015

J of Obstet and Gynaecol

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“…A decrease in the blood flow causes an increase lactic acid, hypoxanthine and lipid peroxide level in the ovarian tissue [14,15]. In patients undergoing ovarian detorsion, there is an increase Fig.…”

Section: Discussionmentioning

confidence: 99%

Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

Incebiyik

Şeker

Camuzcuoğlu

et al. 2014

Arch Gynecol Obstet

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Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation

Cited by 55 publications

References 58 publications

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

Biochemical, Histopathological and Immunohistochemical Evaluation of the Protective and Therapeutic Effects of Thymoquinone against Ischemia and Ischemia/Reperfusion Injury in the Rat Ovary

Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury

Does sildenafil have protective effects against ovarian ischemia-reperfusion injury in rats?

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