Selenium-containing soybean peptides ameliorate intestinal inflammation and modulate gut microbiota dysbacteriosis in DSS-induced ulcerative colitis mice

Abstract

The purpose of this study was to explore the protective effects of selenium containing soybean peptides (SePPs) on inflammatory bowel disease in colitis mice.

Administering Lactiplantibacillus fermentum F6 decreases intestinal Akkermansia muciniphila in a dextran sulfate sodium-induced rat colitis model

“…For example, when analyzed using multivariate analysis methods like principal coordinate analysis, experimental colitis mice induced by 2.5% or 5% DSS showed a distinct difference in the gut microbiota structure from healthy mice, and a lower alpha diversity (assessed by Chao 1, Ace, Shannon, and Simpson indices) was noted in diseased mice compared with the healthy ones. 14,40 Similar outcomes were also observed in a rat model of UC induced by 4% DSS supplement. 41 The common features between these studies are that DSS induction resulted in significantly reduced microbial community richness and evenness and altered gut microbiota structure.…”