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Cited by 334 publications
(256 citation statements)
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“…This fact suggests that the influence of the selenocarbonyl moiety (selenoanhydride, selenoester) and of the secondary carbonyl functional group present in the alkyl moiety bound to selenium in the selenoesters seems to be more relevant for the efflux pump inhibition than the different substituents at the aromatic moiety bound to the carbonyl group of the selenoesters evaluated. As proposed earlier 20,25 , the (1) (2) observed changes of the activity with the functional group can be explained both by the polarity modulation and by the modification of the selenoester hydrolysis exerted by the functional group present in the alkyl moiety bound to the selenium atom. These modifications in the substituents placed at the opposite side of the molecule may exert a minor influence over the selenoester, as these substituents are placed at a higher distance of the selenium atom than the functional groups of the alkyl moiety.…”
Section: A R T I C L E I N F O Abstract Abcb1 (Atp Binding Cassupporting
confidence: 51%
“…This fact suggests that the influence of the selenocarbonyl moiety (selenoanhydride, selenoester) and of the secondary carbonyl functional group present in the alkyl moiety bound to selenium in the selenoesters seems to be more relevant for the efflux pump inhibition than the different substituents at the aromatic moiety bound to the carbonyl group of the selenoesters evaluated. As proposed earlier 20,25 , the (1) (2) observed changes of the activity with the functional group can be explained both by the polarity modulation and by the modification of the selenoester hydrolysis exerted by the functional group present in the alkyl moiety bound to the selenium atom. These modifications in the substituents placed at the opposite side of the molecule may exert a minor influence over the selenoester, as these substituents are placed at a higher distance of the selenium atom than the functional groups of the alkyl moiety.…”
Section: A R T I C L E I N F O Abstract Abcb1 (Atp Binding Cassupporting
confidence: 51%
“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Due to their unique properties, they attracted a wide interest as reagents in new synthetic routes, 3 promising catalysts for various oxidation reactions [1][2][3][4][5][6][7][16][17][18][19] and potential pharmaceuticals. [8][9][10][11][12][13][14][15]20,21 Ebselen (2-phenylbenzisoselenazol-3(2H)-one) and its analogues have received particular attention as glutathione peroxidase mimics, 8,11,15 antioxidant and anti-inflammatory agents. [13][14][15] Furthermore, the continuing interest in this class of compounds has led to the development of various structures with antiviral [22][23][24][25][26] and antimicrobial …”
Section: Introductionmentioning
confidence: 99%
“…Because cancer cells generally exhibit an increased vulnerability to ROS-producing compounds, there is an increasing interest in designing anticancer agents promoting oxidative stress. Among redox active drugs, selenite is a promising candidate as a cancer therapeutic agent (17,151). The next step consists in evaluating its toxicity in cancer patients and the therapeutic potential of redoxactive selenium compounds.…”
Section: Conclusion and Future Perspectivesmentioning
confidence: 99%