Selenium and Selenium-Dependent Antioxidants in Chronic Kidney Disease

Zachara, B

doi:10.1016/bs.acc.2014.11.006

Cited by 81 publications

(63 citation statements)

References 84 publications

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“…Selenium plays critical roles in major metabolic pathways, and is an essential element to protect the body from harmful substances. Recent studies demonstrated that selenium supplementation reduces side effects from chemotherapy and improves kidney and liver functions in cancer patients 16, 19, 20. Analysis of selenium intake by participants in our study revealed inverse associations with RCC risk for both EA and AA, with greater protective effects among AA.…”

Section: Discussionsupporting

confidence: 49%

“…Intake of dietary E vitamins, including α‐, β‐, δ‐, and γ‐tocopherol, is suggested to be chemo‐preventative 16. Supplementation with selenium may influence RCC risk, and selenium has been shown to possess anti‐tumor functions 17, 18, 19, 20. Diets rich in carotenoids, including α‐carotene, β‐carotene, β‐cryptoxanthin, lutein zeaxanthin, and lycopene, have been associated with lower RCC risk 6, 21, 22, 23.…”

Section: Introductionmentioning

confidence: 99%

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Renal cell carcinoma risk associated with lower intake of micronutrients

et al. 2018

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Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample (P‐interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma risk associated with lower intake of micronutrients

et al. 2018

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“…Especially, patients are at risk for low dietary intake of such substances which is attributable to uremia-related anorexia and dietary restrictions. Based on these, some essential TEs may be deficient, thereby causing some complications, which may further lead to an acceleration in disease progression [10,11,12,13,14]. On the other hand, toxic TEs that present in dialysis fluids but not in blood may accumulate.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Trace Element Excretions between Nonanuric and Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

et al. 2016

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Few studies have been reported on alterations of trace elements (TE) in peritoneal dialysis patients. Our objective was to investigate and assess the characteristics of daily TE excretions in continuous ambulatory peritoneal dialysis (CAPD) patients. This cross-sectional study included 61 CAPD patients (nonanuric/anuric: 45/16) and 11 healthy subjects in Wuhan, China between 2013 and 2014. The dialysate and urine of patients and urine of healthy subjects were collected. The concentrations of copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo), and arsenic (As) in dialysate and urine were determined using inductively coupled plasma mass spectrometer (ICP-MS). Various clinical variables were obtained from automatic biochemical analyzer. Daily Cu, Zn, Se, and Mo excretions in nonanuric patients were higher than healthy subjects, while arsenic excretion in anuric patients was lower. A strong and positive correlation was observed between Se and Mo excretion in both dialysate (β = 0.869, p < 0.010) and urine (β = 0.968, p < 0.010). Furthermore, the clinical variables associated with Se excretion were found to be correlated with Mo excretion. Our findings indicated that nonanuric CAPD patients may suffer from deficiency of some essential TEs, while anuric patients are at risk of arsenic accumulation. A close association between Se and Mo excretion was also found.

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“…A large number of reactive oxygen radicals are produced in the kidney, and antioxidants are important in protecting kidney function (5). Increased renal oxidative stress can cause DNA damage and second hits, thus playing an important role in the progression of ADPK disease and cystogenesis (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Thiol/Disulphide Homeostasis in Autosomal Dominant Polycystic Kidney Disease: A Single Center, Cross-Sectional Study

Esen¹,

Kahvecioğlu²,

Üstündağ³

et al. 2018

Turk Neph Dial Transpl

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OBJECTIVE:The aim of this study was to determine a novel oxidative stress marker, plasma thioldisulphide homoeostasis, in patients with autosomal dominant polycystic kidney disease (APKD). MATERIAL and METHODS:Thirty-four patients with autosomal dominant polycystic kidney disease and 30 healthy volunteers were included in the study. The thiol-disulfide homeostasis assay was performed. Total antioxidant capacity was evaluated via the FRAP assay. RESULTS:The median age was 46 (13) years in the patient group and 41 (13) years in the control group. In the APKD disease group, serum total and native thiol levels were statistically significantly lower (p = 0.002, p = 0.002, respectively). Serum native thiol levels were negatively correlated with age (r:-0.620 p: 0,000), systolic blood pressure (r: -0,697 p: 0,000), and diastolic blood pressure (r: -0,643 p: 0,000). A weak positive correlation was found between the disulfide/native thiol ratio and creatinine (r: 0.564 p <0.001), and a negative correlation was found between the disulfide/native thiol ratio and glomerular filtration rate (r: -0.372 p: 0.030). There was a significant positive correlation between the native thiol level and GFR (r: 0.699, p <0.001) level. CONCLUSION:Our findings suggest that thiol/disulfide homeostasis may be associated with autosomal dominant polycystic kidney disease progression. KEY WORDS:Oxidative stress, Autosomal dominant polycystic kidney disease, Thiol-disulphide, Creatinine ÖZ AMAÇ: Bu çalışmanın amacı, otozomal dominant polikistik böbrek (ODPK) hastalığı olanlarda yeni bir oksidatif stres markeri olan plazma tiyol-disülfid homeostazisini belirlemektir. GEREÇ ve YÖNTEMLER:Otozomal dominant polikistik böbrek hastalığı olan 34 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tiyol-disülfid homeostazı ölçüldü. Total antioksidan kapasite FRAP testi ile değerlendirildi. BULGULAR:Hastaların medyan yaşı 46 (13) yıl, kontrol grubunda 41 (13) yıldır. ODPK hastalarında serum total ve nativ tiyol düzeyleri istatistiksel olarak anlamlı derecede düşüktü (sırasıyla p=0,002, p=0,002). Serum nativ tiyol düzeyleri yaş (r:-0,620 p:0,000), sistolik kan basıncı (r:-0,697 p:0,000) ve diyastolik kan basıncıyla (r:-0,643 p:0,000) negatif korelasyon gösterdi. Disülfid / nativ tiyol oranı ile kreatinin arasında (r:0,564 p <0,001) zayıf pozitif korelasyon bulundu, disülfid / nativ tiyol oranı ve glomerüler filtrasyon hızı arasında negatif bir korelasyon bulundu (r:-0,372, p:0,030. Nativ tiyol düzeyi ile GFR arasında pozitif korelasyon bulundu (r:0,699, p<0,001). SONUÇ:Bulgularımız tiyol/disülfid homeostazının otozomal dominant polikistik böbrek hastalığının ilerlemesi ile ilişkili olabileceğini düşündürmektedir.

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Selenium and Selenium-Dependent Antioxidants in Chronic Kidney Disease

Cited by 81 publications

References 84 publications

Renal cell carcinoma risk associated with lower intake of micronutrients

Renal cell carcinoma risk associated with lower intake of micronutrients

Comparative Study on Trace Element Excretions between Nonanuric and Anuric Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

Thiol/Disulphide Homeostasis in Autosomal Dominant Polycystic Kidney Disease: A Single Center, Cross-Sectional Study

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