Selective serotonin reuptake inhibitors have broadened the utilisation of antidepressant treatment in accordance with recommendations

Isacsson, Göran; Boëthius, Göran; Henriksson, S.; Jones, Judith K.; Bergman, Ulf

doi:10.1016/s0165-0327(98)00083-4

Cited by 69 publications

(43 citation statements)

References 45 publications

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“…According to Swedish guidelines, treatment of depression should be for at least a sixmonth period. In agreement with this and the decreased suicide rate, we found six months antidepressant treatment to be three times as common in 1996 as in 1991 in the county of Jämtland (22). Whether there is a causal association between the increased use of antidepressants and the decrease in suicide rate cannot be conclusively established but available data indicates that this is the case (21).…”

Section: The County Of Jämtland Projectsupporting

confidence: 74%

Pharmacoepidemiology – from description to quality assessment. A Swedish perspective

Bergman¹

2009

Nor J Epidemiol

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Parallel with increasing concerns about drug safety, the importance of drug surveillance and the application of epidemiological techniques have grown rapidly during the past decades. The increasing use of computerized health care data facilitates the establishment of populations large enough to allow epidemiological studies. By the use of computerized pharmacy or billing records, drug exposure is linked to files which include outcome data (diagnoses). Pioneering pharmacoepidemiology surveys of prescriptions purchased from defined populations were initiated in the late 1960s. Two such population-based drug databases for research (Jämtland and Tierp) are still in use in Sweden and can provide key epidemiological data such as incidence and prevalence of drug use by age and sex. This basic information on drug use can only be obtained if there is a personal identifier on the prescription. Important studies such as quality of care, polypharmacy, drug interactions, drug abuse and physicians' prescribing habits all require data on drug use by individuals. Unfortunately, because of sensitivity to the issue of data confidentiality in Sweden, the correspondingly recorded data on prescriptions relative to individual patients is not available for use in health care audits or research. With these limitations in access to patient specific data on drug use, focus is now instead on improving the quality of drug prescribing by use of available drug statistics. The number of drugs that account for 90% of the use -the Drug Utilization 90% segment -and adherence to guidelines in this segment are now being tested as general indicators for assessing the quality of drug prescribing.

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Section: The County Of Jämtland Projectsupporting

confidence: 74%

Pharmacoepidemiology – from description to quality assessment. A Swedish perspective

Bergman¹

2009

Nor J Epidemiol

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“…The reported prevalence of antidepressant use in the general population varies between 4% and 13% [7][8][9][10][11]. Figures are higher among females than males and increase with age [7,11].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant utilization patterns and mortality in Swedish men and women aged 20–34 years

Sundell

Gissler

Petzold

et al. 2010

Eur J Clin Pharmacol

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2 Abstract PurposeTo compare antidepressant utilization patterns and mortality in relation to antidepressant use in men and women aged 20-34 years. MethodsWe used data from the Swedish Prescribed Drug Register to identify adults aged 20-34 years who purchased at least one antidepressant in 2006. Information on death and migration was obtained from the Total Population Register by record linkage. One-year prevalence and proportion of new users, amount of purchased antidepressants, concurrent use of other antidepressants, mood stabilizers and antipsychotics as well as mortality was assessed. ResultsThe one-year prevalence of antidepressant use was higher among women than men (7.2% vs. 4.0%, p<0.001), being 5.6% among all Swedes aged 20-34 years (n=94,239). SSRIs dominated at baseline, more common among women than men (78.7% vs. 71.7%, p<0.001). Of the new users, 22.3% filled only one prescription during the study period, men more often than women (24.1% vs. 21.4%, p<0.001). The mortality rate was higher in men than in women (24 vs. 14 per 10,000, p=0.009). Concurrent use of mood stabilizers (48 vs. 16 per 10,000, p<0.001) and antipsychotics (50 vs. 14 per 10,000, p<0.001) was associated with increased mortality in men and women. ConclusionsAlmost twice as many Swedish women than men aged 20-34 years purchased antidepressants in 2006. Differences in utilization patterns between sexes were rather small. Discontinuation rates were high, indicating that increased awareness on attitudes to treatment is needed. In both sexes, mortality rates were elevated among those concurrently using mood stabilizers and antipsychotics which need further investigation.

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“…Algunos autores relacionan directamente la depresión no tratada con el alto riesgo de suicidio (33), y aunque algún estudio sugiere una bajada de la tasa de suicidios con el aumento de la prescripción de antidepresivos (34), (89) otros autores como Barbui encuentran que el incremento en la prescripción de antidepresivos no ha ayudado a prevenir el suicidio (16). Aunque el riesgo de muerte por sobredosis es mayor por ATC, el suicidio por otras vías era más alto en aquellos que tomaban ISRS y los nuevos antidepresivos, así que el riesgo de suicidio no está determinado por el tipo de antidepresivos prescrito (35).…”

Section: Materials Y Métodosunclassified

El incremento en la prescripción de antidepresivos: ¿Una panacea demasiado cara?

Serrano

Lobo²

2004

Rev. Asoc. Esp. Neuropsiq.

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SUMMARYWe study the rise of antidepressants prescribing and the cost increase in a health area in Madrid. We use the National Health System prescriptions from primary care and from specialities during 1999-2001. We analise the consequencies on economy (direct and indirect cost) and on health (temporary disability in the same time and in the same population because of mental disorders). We discuss also some social consequencies.

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Selective serotonin reuptake inhibitors have broadened the utilisation of antidepressant treatment in accordance with recommendations

Cited by 69 publications

References 45 publications

Pharmacoepidemiology – from description to quality assessment. A Swedish perspective

Pharmacoepidemiology – from description to quality assessment. A Swedish perspective

Antidepressant utilization patterns and mortality in Swedish men and women aged 20–34 years

El incremento en la prescripción de antidepresivos: ¿Una panacea demasiado cara?

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