Abstract:Germline antibodies, the initial set of antibodies produced by the immune system, are critical for host defense, and information about their binding properties can be useful for designing vaccines, understanding the origins of autoantibodies, and developing monoclonal antibodies. Numerous studies have found that germline antibodies are polyreactive with malleable, flexible binding pockets. While insightful, it remains unclear how broadly this model applies, as there are many families of antibodies that have no… Show more
“…The disease-related antibodies of the afflicted patients can be rapidly profiled using glycan microarrays. 282,283 In addition, the microarray technology is a useful means of profiling immune responses that are elicited by carbohydrate-based synthetic vaccines. Details of these applications are described in another review article in this themed issue.…”
Section: Profiling Of Anti-glycan Antibodies In Seramentioning
This article summarizes the preparation of glycan probes, the construction of glycan microarrays and their applications for biological and biomedical research.
“…The disease-related antibodies of the afflicted patients can be rapidly profiled using glycan microarrays. 282,283 In addition, the microarray technology is a useful means of profiling immune responses that are elicited by carbohydrate-based synthetic vaccines. Details of these applications are described in another review article in this themed issue.…”
Section: Profiling Of Anti-glycan Antibodies In Seramentioning
This article summarizes the preparation of glycan probes, the construction of glycan microarrays and their applications for biological and biomedical research.
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