Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening

Zhang, Limin; Wang, Liming; Hu, Yili; Liu, Zhigang; Tian, Yuan; Wu, Xiaochun; Zhao, Ye; Tang, Huiru; Chen, Chunying; Wang, Yulan

doi:10.1016/j.biomaterials.2013.05.043

Cited by 77 publications

(58 citation statements)

References 49 publications

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“…The reason is that the release of toxic Ag + from internalized AgNPs was more slowly and most accumulated AgNPs in a non-toxic form in astrocytes. Similar reports revealed that NPs can produce distinct effects on normal cells from cancer cells because lysosomal membranes can endure different stimuli in two types of cells45 and the ability to counteract with and to recover from oxidative stress are quite distinct for two types of cells 46…”

Section: Biological Effects Of Silver Nanoparticlesmentioning

confidence: 73%

Cytotoxic Potential of Silver Nanoparticles

et al. 2014

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Silver nanoparticles (AgNPs) have been widely used in industrial, household, and healthcare-related products due to their excellent antimicrobial activity. With increased exposure of AgNPs to human beings, the risk of safety has attracted much attention from the public and scientists. In review of recent studies, we discuss the potential impact of AgNPs on individuals at the cell level. In detail, we highlight the main effects mediated by AgNPs on the cell, such as cell uptake and intracellular distribution, cytotoxicity, genotoxicity, and immunological responses, as well as some of the major factors that influence these effects in vivo and in vivo, such as dose, time, size, shape, surface chemistry, and cell type. At the end, we summarize the main influences on the cell and indicate the challenges in this field, which may be helpful for assessing the risk of AgNPs in future.

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Section: Biological Effects Of Silver Nanoparticlesmentioning

confidence: 73%

Cytotoxic Potential of Silver Nanoparticles

et al. 2014

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“…The reason is that CTAB molecules form bilayer structures on the Au NR surface and the CTAB bilayer is prone to be dissolved in lipid bilayers after Au NRs attach to the cell membrane [65, 112]. CTAB-coating may disrupt the membrane structures of the endosome/lysosomes and probably have a mitochondrial target to selectively inhibit the growth and migration of cancer cells [31, 113, 114]. …”

Section: Interaction Of Au Nps With Cellsmentioning

confidence: 99%

“…Based on the metabonomic technique, we found that CTAB-coated Au NRs induced distinct effects on the cell viabilities of normal cells and cancer cells. Au NRs induced oxidative stress in both cells lines, but the normal cells are more able to offset the oxidative stress than the cancer cells with evidence of more conversion of GSH to GSSG in normal cells compared to cancer cells [113] (figure 5(d)). These Au NRs were able to induce oxidative stress and up-regulate associated proteins such as heme oxygenase-1 (HO-1) in MEF-1 but not MRC-5 cells [128].…”

Section: Interaction Of Au Nps With Cellsmentioning

confidence: 99%

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Interaction of gold nanoparticles with proteins and cells

Wang

et al. 2015

Science and Technology of Advanced Materials

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Gold nanoparticles (Au NPs) possess many advantages such as facile synthesis, controllable size and shape, good biocompatibility, and unique optical properties. Au NPs have been widely used in biomedical fields, such as hyperthermia, biocatalysis, imaging, and drug delivery. The broad application range may result in hazards to the environment and human health. Therefore, it is important to predict safety and evaluate therapeutic efficiency of Au NPs. It is necessary to establish proper approaches for the study of toxicity and biomedical effects. In this review, we first focus on the recent progress in biological effects of Au NPs at the molecular and cellular levels, and then introduce key techniques to study the interaction between Au NPs and proteins. Knowledge of the biomedical effects of Au NPs is significant for the rational design of functional nanomaterials and will help predict their safety and potential applications.

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“…The newly established metabolomics technology can measure the metabolic changes in a holistic fashion and should be a well-suited tool in the investigation of system metabolic response of E. coli to nicotine. To date, the combination of 1 H nuclear magnetic resonance (NMR) spectroscopy with multivariate data analysis has been widely applied in molecular phenotyping (Dai et al 2010;Swann et al 2013), disease development (Wu et al 2010), pharmacology and toxicity (Zhang et al 2013), and environmental sciences (Rochfort et al 2009). It has been well-demonstrated that systematic 1 H NMR metabolic fingerprints have the potential to aid in the understanding of the xenobiotic-induced metabolic changes in animal tissues (Nicholson et al 1985;Azmi et al 2005;Huang et al 2013) and microorganisms (Ye et al 2012a(Ye et al , 2012b.…”

Section: Introductionmentioning

confidence: 99%

Dynamic metabolomic responses of Escherichia coli to nicotine stress

et al. 2014

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Previously, we reported the metabolic responses of Pseudomonas sp. strain HF-1, a nicotine-degrading bacterium, to nicotine stress. However, the metabolic effects of nicotine on non-nicotine-degrading bacteria that dominate the environment are still unclear. Here, we have used nuclear magnetic resonance based metabolomics in combination with multivariate data analysis methods to comprehensively analyze the metabolic changes in nicotine-treated Escherichia coli. Our results showed that nicotine caused the changes of energy-related metabolism that we believe are due to enhanced glycolysis and mixed acid fermentation as well as inhibited tricarboxylic acid cycle activity. Furthermore, nicotine resulted in the alteration of choline metabolism with a decreased synthesis of betaine but an increased production of dimethylamine. Moreover, nicotine caused a decrease in amino acid concentration and an alteration of nucleotide synthesis. We hypothesize that these changes caused the decrease in bacterial cell density observed in the experiment. These findings provide a comprehensive insight into the metabolic response of E. coli to nicotine stress. Our study highlights the value of metabolomics in elucidating the metabolic mechanisms of nicotine action.

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Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening

Cited by 77 publications

References 49 publications

Cytotoxic Potential of Silver Nanoparticles

Cytotoxic Potential of Silver Nanoparticles

Interaction of gold nanoparticles with proteins and cells

Dynamic metabolomic responses of Escherichia coli to nicotine stress

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