1998
DOI: 10.1016/s0014-5793(98)00082-9
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The CD8 + T cell clone 5F1 produces interleukin 10 (IL-10) and interferon Q Q (IFN-Q Q) in response to stimulation with a peptide corresponding to region 142^149 of bovine K K sI -casein (p142^149). Ninety analog peptides derived from p142^149 with single amino acid substitutions of putative T cell receptor contact residues were prepared to examine whether production of IL-10 and IFN-Q Q by 5F1 can be altered by stimulation with these peptides. We found that some peptides triggered only IL-10 production wherea… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

1998
1998
2008
2008

Publication Types

Select...
5
1

Relationship

2
4

Authors

Journals

citations
Cited by 6 publications
(2 citation statements)
references
References 31 publications
0
2
0
Order By: Relevance
“…Recent studies have revealed that T cells show altered responses to amino acid‐substituted analogs of a specific peptide antigen 67 , 68 . Some analog peptides called partial agonists induce partial activation of T cells: for example, cytokine production without proliferation, 69 alteration of the cytokine production pattern, 70 , 71 and induction of anergy, 72 , 73 due to partial signaling. Another group of analog peptides can inhibit T cell responses to the parent peptide in an antigen‐specific manner and these are designated TCR antagonists 74 .…”
Section: Modulation Of Allergic Reactions By Amino Acid‐substituted Amentioning
confidence: 99%
“…Recent studies have revealed that T cells show altered responses to amino acid‐substituted analogs of a specific peptide antigen 67 , 68 . Some analog peptides called partial agonists induce partial activation of T cells: for example, cytokine production without proliferation, 69 alteration of the cytokine production pattern, 70 , 71 and induction of anergy, 72 , 73 due to partial signaling. Another group of analog peptides can inhibit T cell responses to the parent peptide in an antigen‐specific manner and these are designated TCR antagonists 74 .…”
Section: Modulation Of Allergic Reactions By Amino Acid‐substituted Amentioning
confidence: 99%
“…It has been well documented that changes in the structure and dose of an antigenic peptide modifies T-cell responses, not only in quantity, but also in quality, i.e. partial elicitation of effector functions [1][2][3][4][5] or alteration of cytokine responses [6,7]. In naive CD4 + T cells from TCR-transgenic mice, differences in the structure or dose of an antigenic peptide profoundly affect polarized differentiation into two types of helper T cells, interferon-␥ (IFN-␥)-predominant type-1 and interleukin (IL)-4-predominant type-2 helper T cells (Th1 and Th2) [8][9][10][11].…”
Section: Introductionmentioning
confidence: 99%