Selective Cryolysis of Sebaceous Glands

Jalian, H. Ray; Tam, Joshua; Vuong, Linh N.; Fisher, Jeremy M.; Garibyan, Lilit; Mihm, Martín C.; Zurakowski, David; Evans, Conor L.; Anderson, R. Rox

doi:10.1038/jid.2015.148

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…Evaluation of anti‐acne therapies often uses reduced sebum production or SG involution as positive indicators of efficacy (Jalian et al ., ; Pan, Wang & Tu, ; Trivedi et al ., ), but these may not be desirable outcomes for maintenance of overall skin health, given the important physiological roles of sebum (Smith & Thiboutot, ; Dahlhoff et al ., ; Ehrmann & Schneider, ; Kobayashi et al ., ). Loss of sebum production might also be related to the pathogenesis of other dermatoses such as psoriasis and atopic dermatitis (van Smeden et al ., ; Shi et al ., ; Szántó et al ., ).…”

Section: Final Perspectivesmentioning

confidence: 99%

Neuroendocrinology and neurobiology of sebaceous glands

et al. 2020

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The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention. In particular, the neuro-regulation of sebaceous glands (SGs), a major skin appendage, is rarely considered. Yet, it is clear that the SG is under stringent pituitary control, and forms a fascinating, clinically relevant peripheral target organ in which to study the neuroendocrine and neural regulation of epithelia. Sebum, the major secretory product of the SG, is composed of a complex mixture of lipids resulting from the holocrine secretion of specialised epithelial cells (sebocytes). It is indicative of a role of the neuroendocrine system in SG function that excess circulating levels of growth hormone, thyroxine or prolactin result in increased sebum production (seborrhoea). Conversely, growth hormone deficiency, hypothyroidism, and adrenal insufficiency result in reduced sebum production and dry skin. Furthermore, the androgen sensitivity of SGs appears to be under neuroendocrine control, as hypophysectomy (removal of the pituitary) renders SGs largely insensitive to stimulation by testosterone, which is crucial for maintaining SG homeostasis. However, several neurohormones, such as adrenocorticotropic hormone and α-melanocyte-stimulating hormone, can stimulate sebum production independently of either the testes or the adrenal glands, further underscoring the importance of neuroendocrine control in SG biology. Moreover, sebocytes synthesise several neurohormones and express their receptors, suggestive of the presence of neuro-autocrine mechanisms of sebocyte modulation. Aside from the neuroendocrine system, it is conceivable that secretion of neuropeptides and neurotransmitters from cutaneous nerve endings may also act on sebocytes or their progenitors, given that the skin is richly innervated. However, to date, the neural controls of SG development and function remain poorly investigated and incompletely understood. Botulinum toxin-mediated or facial paresis-associated reduction of human sebum secretion suggests that cutaneous nerve-derived substances modulate lipid and inflammatory cytokine synthesis by sebocytes, possibly implicating the nervous system in acne pathogenesis. Additionally, evidence suggests that cutaneous denervation in mice alters the expression of key regulators of SG homeostasis. In this review, we examine the current evidence regarding neuroendocrine and neurobiological regulation of human SG function in physiology and pathology. We further call attention to this line of research as an instructive model for probing and therapeutically manipulating the mechanistic links between the nervous system and mammalian skin.

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Section: Final Perspectivesmentioning

confidence: 99%

Neuroendocrinology and neurobiology of sebaceous glands

et al. 2020

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“…Cooling disrupts the cellular architecture, membrane integrity, and enzymatic activity in the sebaceous glands. 4 For example, Wheeland and Wiley 16 demonstrated the positive therapeutic effects of cryosurgery on senile SH.…”

Section: Discussionmentioning

confidence: 99%

“…3 In a recent report, cooling damaged the sebaceous glands. 4 Although cryosurgery is known to be effective, there have been no studies about the effects of cryosurgery on SH; therefore, in this research, we aimed to investigate the effects of cryosurgery on SH.…”

mentioning

confidence: 99%

Evaluation of the Efficacy of Cryosurgery in Patients With Sebaceous Hyperplasia of the Face

Ataş

Gönül

2016

J Cutan Med Surg

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“…Cooling disrupted sebocyte membranes, alkaline phosphatase activity, and significantly reduced sebocyte lipid content. 17 The results strongly suggest that acne treatment with modern controlled cooling device is worth investigating.…”

Section: Devices and Proceduresmentioning

confidence: 95%

“…reported about selective cryolysis of sebaceous gland. 17 Cryolipolysis is widely used for local reduction of unwanted subcutaneous fat. 18 Due to the preferential susceptibility of lipid containing cells to cold, they hypothesized that controlled local skin cooling can cause preferential injury to sebaceous gland.…”

Section: Devices and Proceduresmentioning

confidence: 99%

Seeking new acne treatment from natural products, devices and synthetic drug discovery

Yang

Yoon

Kwon

et al. 2017

Dermato-Endocrinology

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Despite lots of research on the pathogenesis of acne, the development of new therapeutic agents is still stagnant. Conventional agents which target multiple pathological processes have some serious side effects and this makes seeking new treatment options important for treating acne. As new therapeutic options, researchers are focusing on natural products, synthetic drugs and devices. From natural products, epigallocatechin-3 gallate, lupeol, cannabidiol and Lactobacillus fermented Chamaecyperis obtusa were reported to be possible candidates for novel drugs, targeting multiple pathogenic factors. Synthetic anti-P.acnes agent, nitric oxide nanoparticles and α-mangostin nanoparticles are shown to be effective in acne treatment. Device or procedural methods such as fractional microneedling radiofrequency, cryolysis, photothermolysis and daylight photodynamic therapy have potential as new treatment options for acne. Further large clinical trials comparing these new treatments with existing agents will be necessary in the future.

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Selective Cryolysis of Sebaceous Glands

Cited by 13 publications

References 23 publications

Neuroendocrinology and neurobiology of sebaceous glands

Neuroendocrinology and neurobiology of sebaceous glands

Evaluation of the Efficacy of Cryosurgery in Patients With Sebaceous Hyperplasia of the Face

Seeking new acne treatment from natural products, devices and synthetic drug discovery

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