Selective Creation of Thermal Injury Zones in the Superficial Musculoaponeurotic System Using Intense Ultrasound Therapy

White, W. Matthew; Makin, Inder Raj S.; Barthé, Peter G.; Slayton, Michael H.; Gliklich, Richard E.

doi:10.1001/archfaci.9.1.22

Cited by 150 publications

(133 citation statements)

References 18 publications

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“…The potential for using this device in treating the aging face is encouraging, and needs to be investigated further in human tissues [24][25][26]. …”

Section: Resultsmentioning

confidence: 99%

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

White

Makin²,

Slayton³

et al. 2008

Lasers Surg Med

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Objective: Various energy delivery systems have been utilized to treat superficial rhytids in the aging face. The Intense Ultrasound System (IUS) is a novel modality capable of transcutaneously delivering controlled thermal energy at various depths while sparing the overlying tissues. The purpose of this feasibility study was to evaluate the response of porcine tissues to various IUS energy source conditions. Further evaluation was performed of the built-in imaging capabilities of the device. Materials and Methods: Simulations were performed on ex vivo porcine tissues to estimate the thermal dose distribution in tissues after IUS exposures to determine the unique source settings that would produce thermal injury zones (TIZs) at given depths. Exposures were performed at escalating power settings and different exposure times (in the range of 1-7.6 J) using three IUS handpieces with unique frequencies and focal depths. Ultrasound imaging was performed before and after IUS exposures to detect changes in tissue consistency. Porcine tissues were examined using nitro-blue tetrazolium chloride (NBTC) staining sensitive for thermal lesions, both grossly and histologically. The dimensions and depth of the TIZs were measured from digital photographs and compared. Results: IUS can reliably achieve discrete, TIZ at various depths within tissue without surface disruption. Changes in the TIZ dimensions and shape were observed as source settings were varied. As the source energy was increased, the thermal lesions became larger by growing proximally towards the tissue surface. Maximum lesion depth closely approximated the pre-set focal depth of a given handpiece. Ultrasound imaging detected well-demarcated TIZ at depths within the porcine muscle tissue. Conclusion: This study demonstrates the response of porcine tissue to various energy dose levels of Intense Ultrasound. Further study, especially on human facial tissue, is necessary in order to understand the utility of this modality in treating the aging face and potentially, other cosmetic applications.

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“…The potential for using this device in treating the aging face is encouraging, and needs to be investigated further in human tissues [24][25][26]. …”

Section: Resultsmentioning

confidence: 99%

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

White

Makin²,

Slayton³

et al. 2008

Lasers Surg Med

Self Cite

View full text Add to dashboard Cite

show abstract

“…By delivering short duration pulses of transcutaneous ultrasound energy, a thermal coagulative damage is produced called thermal injury zone (TIZ) from deep dermis to the superficial musculaponeurotic system (SMAS) [7,8,10].…”

Section: Discussionmentioning

confidence: 99%

“…The transducer is able to selectively target the SMAS, that is a continuous fibroelastic network placed between skin and underlying muscles of facial expression whose mechanical properties lead to greater holding forces [10].…”

Section: Discussionmentioning

confidence: 99%

“…Suh et al reported clinical and histopatologic changes after single MU treatment with a significant improvement in nasolabial fold and jow line appearance, and suggested that MU was a safe, effective and noninvasive procedure that can be used to tighten the facial skin [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…Adverse events include transient mild erythema, edema and rare instances of post inflammatory hyperpigmentation [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

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Selective Creation of Thermal Injury Zones in the Superficial Musculoaponeurotic System Using Intense Ultrasound Therapy

Cited by 150 publications

References 18 publications

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

Selective transcutaneous delivery of energy to porcine soft tissues using intense ultrasound (IUS)

Combination of Treatments in Nonsurgical Facelift Performance to Conduce a Case of Severe Photoaging

Lasers and Optical Technologies in Facial Plastic Surgery

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