Ying-Chun Lo, Michael A. Edidin, Jonathan D. Powell
Activation of T cells through the T cell receptor (TCR) is mediated by the TCR-CD3 signaling complex. Cross linking of this complex with antibodies directed against CD3 leads to potent activation of T cells. However, such activation is not antigen-specific. We exploited the observation that the TCR-CD3 complex is clustered on T cells that have been activated by antigen by using anti-CD3 nanoparticles to selectively activate antigen-experienced mouse T cells. We find that constraining anti-CD3 on the surface o…
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