Selection for Delayed Senescence in Drosophila melanogaster

Luckinbill, Leo S.; Arking, Robert; Clare, Michael J.; Cirocco, William C.; Buck, Steven

doi:10.2307/2408433

Cited by 352 publications

(301 citation statements)

References 11 publications

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“…Other selection experiments by Rose (1984) and Rose and Charlesworth (1980;1981) and Luckinbill et a!. (1984), however, are consistent with evolutionary theories based on genetic control, and present evidence in support of Williams' (1957) notion of pleiotropic gene action.…”

Section: Ntrod U Ct! Onsupporting

confidence: 84%

The effects of gene-environment interaction on the expression of longevity

1985

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Several previous attempts at selecting for increased life span with Drosophila have failed to obtain a response to selection, and postulate that life span is controlled by non-genetic maternal effects instead of genes. In other experiments, however, populations have responded. This study uses a set of true-breeding long-and short-lived stocks developed by in Vitro selection to examine the effect on life span of developmental environment and outcrossing.The expression of genes for life span is shown here to vary as a result of a gene-environment interaction and is strongly affected by the environment during development. The longevity of F1 crosses between long-and short-lived parental lines is additive when the density of larvae is high and unfixed, showing that life span is controlled by genes and not nongenetic maternal effects. But, when numbers of larvae are held low and constant, as in studies where selection fails, life span of crosses and parental lines is greatly restricted. The failure of some previous attempts at selection, therefore, appears to have resulted from the introduction, through experimental design, of strong artifactual environmental effects that Limit the phenotypic expression of genes for life span and the effectiveness of selection.Comparison of fecundity in parental and F1 lines shows that selection for increased life span antagonistically reduces early-life fecundity. Short-lived, parental lines, reproduced at an early age in life, lay 22-24 per cent more eggs in the same period than do long-lived lines selected for reproduction at a late age.

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Section: Ntrod U Ct! Onsupporting

confidence: 84%

The effects of gene-environment interaction on the expression of longevity

1985

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“…Selection increased longevity here as in their study. Other more specific predictions of the Williams (1957) evolutionary model of senescence have been tested with these strains (Luckinbill et a!., 1984), and they appear also to confirm that model. This study extends and completes those data.…”

Section: Discussionmentioning

confidence: 79%

Selection for life span in Drosophila melanogaster

1985

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“…For example, Rose & Charlesworth (1981) and Service & Rose (1985) found high additive genetic variance for fecundity (number of eggs laid) measured during 24-h periods in a laboratory sample of young female fruit flies. In addition, significant variability was observed in populations of Drosophila used in direct selection of longer reproduction times (Luckinbill et a!., 1984;Rose, 1984a).…”

Section: Discussionmentioning

confidence: 99%

Genetic specification of life span and self-fertility in recombinant-inbred strains of Caenorhabditis elegans

Brooks

Johnson

1991

Heredity

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The genetic basis of life-span and age-specific fertility has been analysed using recombinant-inbred strains of the nematode Caenorhabditis elegans. Estimates of narrow-sense heritability range from 0.05 to 0.36 for life span and from 0.36 to 0.49 for total self-fertility. Positive phenotypic and genetic correlations for life span and total fertility were also observed, although in most cases the correlations were not significant. In general, age-specific hermaphrodite fertility was positively correlated with fertility on contiguous days but was negatively correlated with fertility on more distant days. We estimate that a minimum of two to three genes specify each of these traits in this genetic background. Three single-gene markers were used to generate strain distribution patterns, and two of these were found to be linked with loci that specify life span and/or fertility. We also saw evidence for a significant environmental component affecting self-fertility.

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Selection for Delayed Senescence in Drosophila melanogaster

Cited by 352 publications

References 11 publications

The effects of gene-environment interaction on the expression of longevity

The effects of gene-environment interaction on the expression of longevity

Selection for life span in Drosophila melanogaster

Genetic specification of life span and self-fertility in recombinant-inbred strains of Caenorhabditis elegans

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