Selected opioids, ethanol and intake of ethanol

Ethanol consumption and reward are decreased in µ-opiate receptor knockout mice

“…The data are expressed as mean ± standard error of the mean. * Significant post hoc difference using Fisher's PLSD, +/+ vs -/-, P<0.05 Hubbell et al 1986Hubbell et al , 1988aHunter et al 1984;Hyytia and Sinclair 1993;June et al 1998;Le et al 1993;Myers and Critcher 1982;Myers and Lankford 1996;Nestby et al 1999;Petry 1995;Reid and Hunter 1984;Reid et al 1991;Samson and Doyle 1985;Stromberg et al 1998a, b;Volpicelli et al 1986). Although most of these studies have been done in rats, opiate antagonists can also reduce ethanol consumption in mice (Phillips et al 1997).…”

“…Animal models document the abilities of opiate antagonists to reduce ethanol consumption. Opiate antagonists that reduce ethanol consumption in rodents include naloxone Hubbell et al 1986Hubbell et al , 1988aHunter et al 1984;Hyytia and Sinclair 1993;Myers and Critcher 1982;Petry 1995;Reid and Hunter 1984;Reid et al 1991;Samson and Doyle 1985), naltrexone (Cowen et al 1999;Davidson and Amit 1997a, b;Franck et al 1998;June et al 1998;Le et al 1993;Myers and Lankford 1996;Nestby et al 1999;Stromberg et al 1998a, b;Volpicelli et al 1986), nalmefene (June et al 1998), LY117413 (Hubbell et al 1988b), and MR2266 (Volpicelli et al 1986). The specific µ-opiate receptor (MOR) antagonists β-funaltrexamine (Stromberg et al 1998a) and CTOP (Hyytia 1993) also reduce ethanol consumption in some but not all studies (Franck et al 1998;Le et al 1993).…”