Selected Milestones in Antiviral Drug Development

Abstract

This review article will describe the (wide) variety of approaches that I envisaged to develop a specific therapy for viral infections: (i) interferon and its inducers, (ii) HSV, VZV and CMV inhibitors, (iii) NRTIs (nucleoside reverse transcriptase inhibitors), NtRTIs (nucleotide reverse transcriptase inhibitors) and NNRTIs (non-nucleoside reverse transcriptase inhibitors) as HIV inhibitors, (iv) NtRTIs as HBV inhibitors, and finally, (v) the transition of an HIV inhibitor to a stem cell mobilizer, as exemplified by AMD-3100 (Mozobil®).

Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as N-Glycosidation Promoter

“…Whether in their monomeric or oligomeric form, nucleosides represent key biomolecules involved in a wide variety of research areas, spanning from chemistry to biology and from biotechnology to medicine [ 1 , 2 , 3 , 4 , 5 ]. Nucleosides have been the cornerstone of antiviral and anticancer therapy over the past five decades [ 6 , 7 ].…”

Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as N-Glycosidation Promoter

“…Whether in their monomeric or oligomeric form, nucleosides represent key biomolecules involved in a wide variety of research areas, spanning from chemistry to biology and from biotechnology to medicine [ 1 , 2 , 3 , 4 , 5 ]. Nucleosides have been the cornerstone of antiviral and anticancer therapy over the past five decades [ 6 , 7 ].…”

Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as N-Glycosidation Promoter

“…Whether in their monomeric or oligomeric form, nucleosides represent key biomolecules involved in a wide variety of research areas, spanning from chemistry to biology and from biotechnology to medicine [ 1 , 2 , 3 , 4 , 5 ]. Nucleosides have been the cornerstone of antiviral and anticancer therapy over the past five decades [ 6 , 7 ].…”

Synthesis of Natural and Sugar-Modified Nucleosides Using the Iodine/Triethylsilane System as N-Glycosidation Promoter

“…Whether in their monomeric or oligomeric form, nucleosides represent key biomolecules involved in a wide variety of research areas, spanning from chemistry to biology and from biotechnology to medicine [ 1 , 2 , 3 , 4 , 5 ]. Nucleosides have been the cornerstone of antiviral and anticancer therapy over the past five decades [ 6 , 7 ].…”