Selbstorganisierte Multivalenz: dynamische Ligandenanordnungen für hochaffine Bindungen

Barnard, Anna; Smith, David K.

doi:10.1002/ange.201200076

Cited by 37 publications

(8 citation statements)

References 101 publications

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“…[ 108 ] These interactions are prominent in the realm of biology, for example, between nucleobases in DNA, neighboring proteins, and enzymes and substrates, all which involve noncovalent forces to perform specifi c functions. [ 109 ] Polymer chemists have integrated supramolecular chemistry to fabricate dynamic materials owing to the reversible nature of the noncovalent interaction. Addition of supramolecular recognition units onto either the main-chains or side-chains of polymers has the potential to afford dynamic, yet highly modular materials.…”

Section: Peptides As Self-assembling Unitsmentioning

confidence: 99%

“…Some examples of commonly used molecular recognition units are hydrogen bonding, metal‐coordination, π–π‐stacking, and host–guest complexation . These interactions are prominent in the realm of biology, for example, between nucleobases in DNA, neighboring proteins, and enzymes and substrates, all which involve noncovalent forces to perform specific functions . Polymer chemists have integrated supramolecular chemistry to fabricate dynamic materials owing to the reversible nature of the noncovalent interaction.…”

Section: Applications Of Polymer‐protein Conjugatesmentioning

confidence: 99%

See 1 more Smart Citation

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

Borchmann

Carberry

Weck

2013

Macromol. Rapid Commun.

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Polymer-protein conjugates are biohybrid macromolecules derived from covalently connecting synthetic polymers with polypeptides. The resulting materials combine the properties of both worlds: chemists can engineer polymers to stabilize proteins, to add functionality, or to enhance activity; whereas biochemists can exploit the specificity and complexity that Nature has bestowed upon its macromolecules. This has led to a wealth of applications, particularly within the realm of biomedicine. Polymer-protein conjugation has expanded to include scaffolds for drug delivery, tissue engineering, and microbial inhibitors. This feature article reflects upon recent developments in the field and discusses the applications of these hybrids from a biomaterials standpoint.

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Section: Peptides As Self-assembling Unitsmentioning

confidence: 99%

Section: Applications Of Polymer‐protein Conjugatesmentioning

confidence: 99%

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

Borchmann

Carberry

Weck

2013

Macromol. Rapid Commun.

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“…[5] Leroy Cronin (University of Glasgow) studierte an der University of York und promovierte dort 1997 bei Paul H. Walton. 1997-1999 verbrachte er als Royal Society European Exchange Fellow bei FranÅois Diederich an der ETH Zürich, und 1999 begann er seine unabhängige Forschung an der University of York, an der er nun Professor ist.…”

Section: Harrison-meldola-preiseunclassified

Preise der Royal Society of Chemistry 2012

2012

Angewandte Chemie

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Diese Preise werden für die anerkennenswertesten und vielversprechendsten Studien in der Chemie verliehen, die ein Wissenschaflter von maximal 32 Jahren verçffentlicht hat.Michael J. Ingleson (University of Manchester) studierte an der University of Bath und promovierte 2004 bei Andrew S. Weller. Er war Postdoc bei Kenneth G. Caulton an der Indiana University (2004)(2005) und bei Matthew Rosseinsky an der University of Liverpool (2006Liverpool ( -2008; derzeit ist er mit einem Royal Society University Research Fellowship an der University of Manchester. Inglesons Interesse gilt der Hauptgruppen-und Organometallchemie. [2] Tuomas P. J. Knowles (University of Cambridge) studierte an der ETH Zürich und promovierte 2008 bei Mark E. Welland und Christopher M. Dobson an der University of Cambridge. Nach weiterer Forschungstätigkeit an dieser Einrichtung wurde er dort 2010 zum Lecturer ernannt. Er befasst sich mit dem Einsatz physikalischer Techniken zur Untersuchung biomolekularer Systeme. [3] Marina K. Kuimova (Imperial College London) studierte an der staatlichen Universität Moskau und promovierte 2005 bei Michael W. George an der University of Nottingham. Derzeit arbeitet sie als EPSRC Career Acceleration Fellow am Imperial College London. In ihrer Forschung geht es um die Verwendung von Bildgebungs-und spektroskopischen Techniken zur Untersuchung der Zellfunktion und ultraschneller Prozesse in Biomolekülen. [4]

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“…Intrinsically, self‐assembly is a “bottom‐up” construction process, which starts from readily accessible monomeric building blocks that assemble into higher‐order structures. This characteristic offers an excellent platform for the construction of multivalent ligands, which can simultaneously interact with multiple complementary receptors 16,17. The design of the supramolecular building block dictates the topology of the resulting self‐assembled architecture.…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembling Multivalency – Supramolecular Polymers Assembled from Monovalent Mannose‐Labelled Discotic Molecules

Petkau-Milroy

Brunsveld

2013

Eur J Org Chem

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Supramolecular synthesis, the “bottom‐up” construction of higher‐order structures from monomeric building blocks, represents a flexible approach for the generation of multivalent materials. Here, monovalent building blocks decorated with a single bioactive ligand were synthesized. In water, these supramolecular elements self‐assemble into columnar polymers that display multiple ligands. The supramolecular effect on the binding affinity was evaluated by using an enzyme‐linked lectin assay, and the self‐assembled architecture exhibited a stronger inhibitory power than that of the monovalent bioactive ligand. This so‐called self‐assembling multivalency enables the rapid and flexible generation of multivalent polymers from monovalent building blocks.

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Selbstorganisierte Multivalenz: dynamische Ligandenanordnungen für hochaffine Bindungen

Cited by 37 publications

References 101 publications

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

“Bio”‐Macromolecules: Polymer‐Protein Conjugates as Emerging Scaffolds for Therapeutics

Preise der Royal Society of Chemistry 2012

Self‐Assembling Multivalency – Supramolecular Polymers Assembled from Monovalent Mannose‐Labelled Discotic Molecules

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