Seizure Relapse and Development of Drug Resistance Following Long-term Seizure Remission

Abstract

To quantify and identify predictive risk factors for seizure relapse and development of drug resistance in patients who achieved long-term (Ͼ1 year) antiepileptic drug-induced seizure remission.

Risk of breakthrough seizures depends on type and etiology of epilepsy

“…Almost one in three patients in our cohort experienced a breakthrough seizure; this rate falls within the lower range reported in previous studies 3,15 . Given the substantial rate of breakthrough seizures, the paucity of studies focusing on this phenomenon is striking.…”

Risk of breakthrough seizures depends on type and etiology of epilepsy

“…Almost one in three patients in our cohort experienced a breakthrough seizure; this rate falls within the lower range reported in previous studies 3,15 . Given the substantial rate of breakthrough seizures, the paucity of studies focusing on this phenomenon is striking.…”

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

“…We also observed a difference in the age at onset between the responsiveness to SCN-ASMs and the more restricted predominant SCN-ASMs. In previous studies, the age at onset was not related to the responsiveness to ASMs [ 2 , 40 – 42 ]. This could be caused by bias due to the relatively small sample size in our study, which is crucial to genetic association studies [ 43 ].…”

Imágenes por resonancia magnética anormales como predictoras de mal pronóstico en epilepsia focal

“…Se observa predominancia en el diagnóstico de esclerosis del hipocampo en los pacientes con epilepsia temporal, tanto en el grupo de enfermos respondedores como no respondedores. En la epilepsia extratemporal se observa con mayor frecuencia la presencia de malformaciones del desarrollo cortical y/o tumores, que fueron consideradas en el mismo citado 3,4,25,26 . Esto se debe a que nuestro centro es un lugar de referencia, que recibe casos de difícil manejo de todo el país.…”

Risk of breakthrough seizures depends on type and etiology of epilepsy

“…Almost one in three patients in our cohort experienced a breakthrough seizure; this rate falls within the lower range reported in previous studies 3,15 . Given the substantial rate of breakthrough seizures, the paucity of studies focusing on this phenomenon is striking.…”

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

“…We also observed a difference in the age at onset between the responsiveness to SCN-ASMs and the more restricted predominant SCN-ASMs. In previous studies, the age at onset was not related to the responsiveness to ASMs [ 2 , 40 – 42 ]. This could be caused by bias due to the relatively small sample size in our study, which is crucial to genetic association studies [ 43 ].…”

Imágenes por resonancia magnética anormales como predictoras de mal pronóstico en epilepsia focal

“…Se observa predominancia en el diagnóstico de esclerosis del hipocampo en los pacientes con epilepsia temporal, tanto en el grupo de enfermos respondedores como no respondedores. En la epilepsia extratemporal se observa con mayor frecuencia la presencia de malformaciones del desarrollo cortical y/o tumores, que fueron consideradas en el mismo citado 3,4,25,26 . Esto se debe a que nuestro centro es un lugar de referencia, que recibe casos de difícil manejo de todo el país.…”

Risk of breakthrough seizures depends on type and etiology of epilepsy

“…Almost one in three patients in our cohort experienced a breakthrough seizure; this rate falls within the lower range reported in previous studies 3,15 . Given the substantial rate of breakthrough seizures, the paucity of studies focusing on this phenomenon is striking.…”

Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

“…We also observed a difference in the age at onset between the responsiveness to SCN-ASMs and the more restricted predominant SCN-ASMs. In previous studies, the age at onset was not related to the responsiveness to ASMs [ 2 , 40 – 42 ]. This could be caused by bias due to the relatively small sample size in our study, which is crucial to genetic association studies [ 43 ].…”

Imágenes por resonancia magnética anormales como predictoras de mal pronóstico en epilepsia focal

“…Se observa predominancia en el diagnóstico de esclerosis del hipocampo en los pacientes con epilepsia temporal, tanto en el grupo de enfermos respondedores como no respondedores. En la epilepsia extratemporal se observa con mayor frecuencia la presencia de malformaciones del desarrollo cortical y/o tumores, que fueron consideradas en el mismo citado 3,4,25,26 . Esto se debe a que nuestro centro es un lugar de referencia, que recibe casos de difícil manejo de todo el país.…”