Seizure Disorders in Patients with Brain Tumors

Liigant, Aive; Haldre, Sulev; Õun, Andre; Linnamägi, Ülla; Saar, Anu; Asser, Toomas; Kaasik, Ain‐Elmar

doi:10.1159/000052089

Cited by 103 publications

(66 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Approximately 40%-90% of patients with LGG have epilepsy. 4,13,27 Thus, they often require prophylactic anticonvulsant medication. Anticonvulsants are known for their teratogenic effects and could be a major impediment for pregnancy, causing possible birth defects.…”

Section: Discussionmentioning

confidence: 99%

The effect of pregnancy on survival in a low-grade glioma cohort

Rønning

Helseth

Meling

et al. 2016

JNS

View full text Add to dashboard Cite

A dult low-grade gliomas (LGGs; World Health Organization [WHO] Grade II) are progressive brain tumors with diffuse borders against normal brain tissue and have a propensity to spread in an infiltrative manner throughout the brain. 16 These tumors demonstrate a tendency to evolve into more aggressive highgrade gliomas (HGGs). WHO Grade I tumors are also usually termed "LGG." However, the nature of these lesions is quite different from their Grade II counterpart in that the Grade I tumor is not infiltrative and usually demonstrates more compact growth characteristics, making it more amenable to complete resection.LGGs compose approximately 15% of all gliomas. 26 Patients most often present with seizures, but they can also demonstrate neurological and cognitive deficits or complain of headache.2,26 There is a clear tendency for patients with these tumors to present earlier in life than those with higher-grade tumors, with the median age at diagnosis being between 40 and 50 years. 11Therefore, female patients are often diagnosed with LGG while within their reproductive years. As clinicians, we are often questioned and expected to counsel female patients on the issue of how pregnancy and delivery affects the biology of their LGG and, ultimately, their own survival. To our knowledge, only 2 other reports detail the effects of pregnancy on patients with LGG. These reports originate from the French glioma study group and feature information on the clinical symptoms and speed of tumor growth in 11 patients and 12 pregnancies.19, 21 The results indicate that there is a peri-gestational increase in lesion growth rates witnessed on MR images. However, is it still unknown how this affects outcome and survival.Since patients often present with seizures, they are

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of pregnancy on survival in a low-grade glioma cohort

Rønning

Helseth

Meling

et al. 2016

JNS

View full text Add to dashboard Cite

show abstract

“…The differential diagnosis of DNT includes ganglioma, oligodendroglioma, oligoastrocytoma, and benign cerebral cysts. 3,4,[6][7][8][9][10]14,15) Long-term follow up and observation are essential. Our patient has had an uneventful clinical course for more than 4 years after surgery, with no neurological sequelae and no recurrence of seizures.…”

Section: Discussionmentioning

confidence: 99%

Electroencephalography-Guided Resection of Dysembryoplastic Neuroepithelial Tumor -Case Report-

Imataka

Ogino

Nakagawa

et al. 2008

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 3-year-old girl presented with a dysembryoplastic neuroepithelial tumor in the right cingulate gyrus manifesting as epilepsy refractory to anticonvulsant medication. Computed tomography and magnetic resonance imaging revealed a cystic tumor in the right cingulate gyrus. The tumor was removed under intraoperative electrocorticography guidance. Abnormal spikes recorded adjacent to the tumor disappeared immediately after total removal. Histological examination showed a multinodular, multicystic structure, satisfying the criteria for the diagnosis of dysembryoplastic neuroepithelial tumor. She has remained seizure-free for more than 4 years without complications. In this case, intraoperative electrocorticography was very useful to identify the possible focus and prevent unnecessary resection of the adjacent tissue. Total removal of the tumor resulted in a dramatic reduction of seizure activity.

show abstract

“…Seizures are also very common in CNS tumor subjects with roughly 15-95% of subjects experiencing at least one seizure during the course of their disease process [8]. Interestingly, seizures are more common in subjects aged 30-50 years and are frequently associated with tumors involving the frontal, temporal, frontotemporal, and frontoparietal lobes [9].…”

Section: Gliomasmentioning

confidence: 99%

Advances in the Treatment of Primary Brain Tumors: The Realm of Immunotherapy

Strong¹,

Ware²

2017

New Approaches to the Management of Primary and Secondary CNS Tumors

View full text Add to dashboard Cite

Central nervous system (CNS) tumors, although rare, represent a group of neoplasms that have a disproportionate morbidity and mortality. Despite advances in our understanding of tumor pathogenesis coupled with improvements in therapeutic options, overall survival for primary brain tumors remains dismal. Although challenging, newer approaches such as brachytherapy, immunotherapy, and electric field generators are currently being evaluated in the clinical setting with promising results. The field of immunotherapy in neurooncology is still in its infancy, but several advances have already been made, including the development of tumor vaccines, utilization of immune checkpoint inhibitors, and activation of tumor dendritic cells to stimulate the host's immune system. Recent advances in noninvasive electric fields have been applied to the treatment of glioblastoma multiforme (GBM) with encouraging clinical outcome. In this chapter, we will review the latest advances in the treatment of glioblastoma multiforme with a focus on immunotherapy.

show abstract

Seizure Disorders in Patients with Brain Tumors

Cited by 103 publications

References 15 publications

The effect of pregnancy on survival in a low-grade glioma cohort

The effect of pregnancy on survival in a low-grade glioma cohort

Electroencephalography-Guided Resection of Dysembryoplastic Neuroepithelial Tumor -Case Report-

Advances in the Treatment of Primary Brain Tumors: The Realm of Immunotherapy

Contact Info

Product

Resources

About