Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy

Li, Xin; Yang, Huifang; Yan, Jiaqing; Wang, Xingran; Yuan, Yi; Li, Xiaoli

doi:10.1016/j.eplepsyres.2019.04.002

Cited by 41 publications

(28 citation statements)

References 42 publications

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“…While ultrasound neuromodulation has been gaining increasing attention, little is known on the range of acoustic parameters and different modes of ultrasound that elicit a response. Li et al found that continuous and pulsed waves both decreased the intensity of the power spectrum at low frequencies (<10 Hz) and increased the interval between seizures, while the phase-amplitude coupling strength between slow (delta-, theta-, and alpha-frequency bands) and fast (gamma-frequency bands) neural oscillations was weakened [ 30 ]. King et al found that continuous-wave stimuli were equally, if not more, effective than pulsed-wave stimuli were in eliciting responses [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…King et al reported that short-duration continuous-wave ultrasound stimuli were equally, if not more, effective than pulsed stimuli in eliciting motor responses [ 29 ]. Moreover, Li and colleagues found that continuous and pulsed waves decreased the intensity of the power spectrum in local field potentials of epileptic mice and increased the interval between seizures [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Zhang

Liu

et al. 2021

Micromachines

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Epilepsy is common brain dysfunction, where abnormal synchronized activities can be observed across multiple brain regions. Low-frequency focused pulsed ultrasound has been proven to modulate the epileptic brain network. In this study, we used two modes of low-intensity focused ultrasound (pulsed-wave and continuous-wave) to sonicate the brains of KA-induced epileptic rats, analyzed the EEG functional brain connections to explore their respective effect on the epileptic brain network, and discuss the mechanism of ultrasound neuromodulation. By comparing the brain network characteristics before and after sonication, we found that two modes of ultrasound both significantly affected the functional brain network, especially in the low-frequency band below 12 Hz. After two modes of sonication, the power spectral density of the EEG signals and the connection strength of the brain network were significantly reduced, but there was no significant difference between the two modes. Our results indicated that the ultrasound neuromodulation could effectively regulate the epileptic brain connections. The ultrasound-mediated attenuation of epilepsy was independent of modes of ultrasound.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Zhang

Liu

et al. 2021

Micromachines

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“…US stimulation of the nervous system can have short-term and long-term effects. In the short-term, US stimulation directly activates neurons in the hippocampus and controls the translation of the neuronal signal through synaptic sodium and calcium channels [ 99 , 100 , 101 , 102 , 103 , 104 , 105 ]. In the long-term, US stimulation modulates levels of the extracellular neurotransmitters—serotonin, dopamine, and ƴ-aminobutyric acid—potentially enabling the treatment of epilepsy and other CNS-associated disorders.…”

Section: Applications Of Low-intensity Continuous Ultrasoundmentioning

confidence: 99%

“…In the long-term, US stimulation modulates levels of the extracellular neurotransmitters—serotonin, dopamine, and ƴ-aminobutyric acid—potentially enabling the treatment of epilepsy and other CNS-associated disorders. A recent study by Xin et al reported that LIPUS and LICUS decreased local field potentials, phase-amplitude coupling strength, and the interval between seizures in an epileptic mouse model [ 103 ]. Studies conducted by Liu et al and Zhao et al have demonstrated long-term neuroprotective effects of US stimulation in neurodegenerative disorders, such as Parkinson’s and Alzheimer’s [ 104 , 105 , 106 ].…”

Section: Applications Of Low-intensity Continuous Ultrasoundmentioning

confidence: 99%

Low-Intensity Continuous Ultrasound Therapies—A Systematic Review of Current State-of-the-Art and Future Perspectives

Uddin

Komatsu

Motyka

et al. 2021

JCM

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Therapeutic ultrasound has been studied for over seven decades for different medical applications. The versatility of ultrasound applications are highly dependent on the frequency, intensity, duration, duty cycle, power, wavelength, and form. In this review article, we will focus on low-intensity continuous ultrasound (LICUS). LICUS has been well-studied for numerous clinical disorders, including tissue regeneration, pain management, neuromodulation, thrombosis, and cancer treatment. PubMed and Google Scholar databases were used to conduct a comprehensive review of all research studying the application of LICUS in pre-clinical and clinical studies. The review includes articles that specify intensity and duty cycle (continuous). Any studies that did not identify these parameters or used high-intensity and pulsed ultrasound were not included in the review. The literature review shows the vast implication of LICUS in many medical fields at the pre-clinical and clinical levels. Its applications depend on variables such as frequency, intensity, duration, and type of medical disorder. Overall, these studies show that LICUS has significant promise, but conflicting data remain regarding the parameters used, and further studies are required to fully realize the potential benefits of LICUS.

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“…Hakimova et al showed that the recurrence time of seizure increased by pulsed ultrasound stimulation in mouse model of mesial temporal lobe epilepsy induced by kainic acid, and social interaction scores were higher for mice with stimulation than for mice without stimulation in the behavioral test. Chen et al investigated effective LIFUS parameters in rats with epilepsy induced by PTZ and demonstrated that LIFUS inhibited epileptic seizure by regulating pAKT, S6, and pI3K-Akt-mTOR pathways [9][10][11][12]. In previous studies, only the number of epileptic spikes and epileptiform activity in the electroencephalogram (EEG) were analyzed [10,12].…”

Section: Introductionmentioning

confidence: 99%

Modulation of EEG Frequency Characteristics by Low-Intensity Focused Ultrasound Stimulation in a Pentylenetetrazol-Induced Epilepsy Model

et al. 2021

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Treatments for epilepsy include pharmacotherapy or surgery. Recently, focused ultrasound stimulation has been investigated as a promising non-invasive neuromodulation tool for neurological disorders, including epilepsy. To investigate the neuronal dynamics in epilepsy, we acutely stimulated 29 Sprague-Dawley rats to low-intensity focused ultrasound stimulation (LIFUS) three times for 3 minutes. Pentylenetetrazol (PTZ) was injected into the abdominal cavity of the anesthetized rats to induce epilepsy. During the anesthesia, the electroencephalography (EEG) signal was measured and analyzed for 1 h in groups of animals untreated (sham) and treated with LIFUS. The EEG signal was quantitatively processed to show the different characteristics of the frequency change over time and of the band power between sham and treated groups. Histological analyses (Nissl, Iba1, c-Fos, and GAD65) measured the degree of staining of expression factors to confirm the effect of the stimulation on seizure suppression. These results suggest that repetitive LIFUS can effectively reduce epileptic seizure activity by attenuating theta and betaband oscillation in a PTZ-induced rat model. LIFUS can potentially facilitate hippocampal and cortical cellular recovery by augmenting GABAergic inhibitory neurons via its anti-seizure effect.

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Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy

Cited by 41 publications

References 42 publications

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Different Modes of Low-Frequency Focused Ultrasound-Mediated Attenuation of Epilepsy Based on the Topological Theory

Low-Intensity Continuous Ultrasound Therapies—A Systematic Review of Current State-of-the-Art and Future Perspectives

Modulation of EEG Frequency Characteristics by Low-Intensity Focused Ultrasound Stimulation in a Pentylenetetrazol-Induced Epilepsy Model

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