Sedative effects of Iranian<i>Artemisia annua</i>in mice: Possible benzodiazepine receptors involvement

Emadi, Fatemeh; Yassa, Narguess; Hadjiakhoondi, Abbas; Beyer, Cordian; Sharifzadeh, Mohammad

doi:10.3109/13880209.2010.548389

Cited by 13 publications

(7 citation statements)

References 19 publications

(29 reference statements)

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“…For each sample, approximately 50,000 high-quality 16S rRNA 31 gene sequences were obtained after high-throughput sequencing 43 . The rarefaction curve became flat, indicating that the amounts of operational taxonomic units (OTUs) reached saturation for all samples (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Time-course relationship between environmental factors and microbial diversity in tobacco soil

Wang

Yang

Xia

et al. 2019

Sci Rep

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Soil physicochemical properties and microbial diversity both play equally important roles in tobacco cultivation. However, the relationship between these factors remains unclear. In this study, we investigated their correlations through the whole tobacco growth period, including the pretransplanting (YX-p), root extending (R), flourishing (F), and mature (M) stages in the Yuxi region of the Yunnan-Guizhou Plateau by measuring physicochemical properties and conducting 16S/18S rRNA analysis. The analysis demonstrated that the microbial community richness and diversity continuously changed along with the growth course of the tobacco. Multiple environmental factors showed a certain correlation with the diversity of microbial communities. Some bacteria could accumulate nitrogen during the growth stages, and the diversity of the bacterial community also increased when the content of organic matter rose. In addition, the water content and available K also influenced the diversity of the microbial community. The dynamic changes in soil physicochemical properties and enzyme activities gave rise to differences in the microbial community composition and structure, all of which affected the growth of tobacco. This study revealed the time-course relationship between environmental factors and microbial diversity in tobacco soil. An understanding of this relationship provides guidance for research on the interaction system of plants, soil and microbes and on improving plant yield and quality.

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Section: Resultsmentioning

confidence: 99%

Time-course relationship between environmental factors and microbial diversity in tobacco soil

Wang

Yang

Xia

et al. 2019

Sci Rep

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“…ART-mediated sedative effect is probably linked to benzodiazepine receptors * Significantly different from controls (P<0.05). [8]. However, in GH 3 cells treated with iloprost, a prostacyclin analog, or chlorotoxin, ARTinduced block of I K(DR) or I Na remained unaffected.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study reported the ability of ART in influencing the amplitude of ionic currents in neurons isolated from nodose ganglia [7]. ARTmediated sedative effects are also thought to be the consequence of the binding to central benzodiazepine receptors [8]. However, the detailed studies regarding ionic mechanism of ART actions on neurons or endocrine cells (e.g., pituitary cells) were not reported.…”

Section: Introductionmentioning

confidence: 95%

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Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells

Wu³

et al. 2017

Cell Physiol Biochem

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Background: Artemisinin (ART) is an anti-malarial agent reported to influence endocrine function. Methods: Effects of ART on ionic currents and action potentials (APs) in pituitary tumor (GH₃) cells were evaluated by patch clamp techniques. Results: ART inhibited the amplitude of delayed-rectifier K⁺ current (I_K(DR)) in response to membrane depolarization and accelerated the process of current inactivation. It exerted an inhibitory effect on I_K(DR) with an IC₅₀ value of 11.2 µM and enhanced I_K(DR) inactivation with a K_D value of 14.7 µM. The steady-state inactivation curve of I_K(DR) was shifted to hyperpolarization by 10 mV. Pretreatment of chlorotoxin (1 µM) or iloprost (100 nM) did not alter the magnitude of ART-induced inhibition of I_K(DR) in GH₃ cells. ART also decreased the peak amplitude of voltage-gated Na⁺ current (I_Na) with a concentration-dependent slowing in inactivation rate. Application of KMUP-1, an inhibitor of late I_Na, was effective at reversing ART-induced prolongation in inactivation time constant of I_Na. Under current-clamp recordings, ART alone reduced the amplitude of APs and prolonged the duration of APs. Conclusion: Under ART exposure, the inhibitory actions on both I_K(DR) and I_Na could be a potential mechanisms through which this drug influences membrane excitability of endocrine or neuroendocrine cells appearing in vivo.

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“…[ 1 ] Other reports have shown that the effect of AAH on intestinal microbiota, clostridium perfringens infection,[ 2 ] and in vitro trematocidal effects. [ 3 ] Furthermore, several reports have demonstrated sedative effects of AAH in mice[ 4 ] and against Rhipicephalus . [ 5 ] In addition, recent studies have shown that the effect of AAH against monogenean parasites[ 6 ] and its immunosuppressive effect.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of Artemisiae annuae herba in lipopolysaccharide-stimulated RAW 264.7 Cells

Jeong

Kim

et al. 2014

Phcog Mag

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Background:Artemisiae annuae herba (AAH) has been traditionally used as a drug for the treatment of malaria, heat stroke, bacterial infection, and fever in East-Asia. Although AAH has been used for the treatment of inflammation-related symptoms, the underlying mechanism of antiinflammatory activity of AAH is still unknown.Objective:We investigated whether AAH have an inhibitory effect on the production of pro-inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.Materials and Methods:The investigation was forced on the inhibitory effect of AAH on the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, nitric oxide (NO), and inducible NO synthase (iNOS) in macrophages. Furthermore, we examined the effect of AAH on the activation of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) pathways.Results:We found that AAH suppresses NO production and TNF-α, IL-6, and iNOS gene expression. Moreover, AAH inhibited the nuclear translocation of p65 and IκBα degradation in NF-κB pathway and decreased the extracellular signal-regulated kinase, p38, c-Jun NH2-terminal kinase phosphorylation in MAPK signaling pathway.Conclusions:Consequently, these results indicate that AAH contains antiinflammatory activity and this effect is derived from the repression on the activation of NF-κB and MAPKs pathways. We first demonstrated that antiinflammatory effect of AAH and its underlying mechanism in macrophage cells.

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Sedative effects of IranianArtemisia annuain mice: Possible benzodiazepine receptors involvement

Cited by 13 publications

References 19 publications

Time-course relationship between environmental factors and microbial diversity in tobacco soil

Time-course relationship between environmental factors and microbial diversity in tobacco soil

Synergistic Inhibition of Delayed Rectifier K+ and Voltage-Gated Na+ Currents by Artemisinin in Pituitary Tumor (GH3) Cells

Anti-inflammatory effect of Artemisiae annuae herba in lipopolysaccharide-stimulated RAW 264.7 Cells

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