Sedative effect of intramuscular medetomidine with and without vatinoxan (MK-467), and its reversal with atipamezole in sheep

Adam, Magdy; Raekallio, Marja; Vainio, Outi

doi:10.1016/j.vaa.2018.06.009

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Similar finding is also reported when medetomidine and vatinoxan was administered to dogs (Restitutti et al, 2017).Also, the co-administration of vatinoxan significantly increased the level of medetomidine sedation. Adam et al (2018) found that vatinoxan addition in sheep increased dexmedetomidine concentration in plasma by three fold after 20 minutes, when compared with the values of medetomidine alone. Addition of vatinoxan approximately doubled the plasma concentrations of dexmedetomidine at 30 minutes compared with medetomidine alone.…”

Section: Clinical Usesmentioning

confidence: 85%

“…Medetomidine (50 µgm/ kg) induced higher degree of sedation than xylazine (1.1mg/ kg) (Cardoso et al, 2011). Adam et al (2018) reported concomitant intramuscular administration of vantinoxan and medetomidine produce a faster induction in sheep than medetomidine alone. Similar finding is also reported when medetomidine and vatinoxan was administered to dogs (Restitutti et al, 2017).Also, the co-administration of vatinoxan significantly increased the level of medetomidine sedation.…”

Section: Clinical Usesmentioning

confidence: 99%

See 1 more Smart Citation

Systemic Effects and Clinical Application of Medetomidine in Animals: A Review

Kumar

Singh

Verma

et al. 2020

IJAR

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Medetomidine is most potent á-2 adrenergic selective agonist, produces consistent sedation, anxiolysis and muscle relaxation, which makes it a popular sedative agent in veterinary anaesthesia. It produces dose dependent sedation and analgesia in animals. In veterinary practice it is used for premedication and as an adjunct to general anaesthesia in several species. Similar to other alpha-2 agonists it exerts its effect through the action on alpha-2 adrenergic receptors. The sedative and anxiolytic effects of á-2 agonists are mediated by agonism of supraspinal autoreceptors situated in the pons, whereas analgesic effects are mediated by agonism of heteroreceptors located in the dorsal horn of the spinal cord. Medetomidine through stimulation of central and peripheral adrenoreceptors, significantly affect cardiovascular function. Medetomidine reduces both rate and depth of respiration. Medetomidine generally used along with butorphanol for premedication prior to induction of general anaesthesia. Medetomidine administration reduces both injectable and inhalant anesthetic requirements in several species.

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Section: Clinical Usesmentioning

confidence: 85%

Section: Clinical Usesmentioning

confidence: 99%

Systemic Effects and Clinical Application of Medetomidine in Animals: A Review

Kumar

Singh

Verma

et al. 2020

IJAR

View full text Add to dashboard Cite

show abstract

“…1 In a second study, the drug combination resulted in higher sedation scores and improved recovery following atipamezole reversal. 2 Alpha-2s can be reversed with α-2 antagonist agents including yohimbine, tolazoline and atipamezole. In recent years, yohimbine and tolazoline have been difficult to obtain due to manufacture backorder or discontinuation of production.…”

Section: Alpha-2 Sedativesmentioning

confidence: 99%