Secondary metabolites from the marine‐derived fungus Paraconiothyrium sp. VK‐13

Abstract

Chemical investigation of a fermentation culture of the marine endophytic fungus Paraconiothyrium sp. VK‐13 resulted in the isolation of five compounds, including a new phenolic compound, 1‐(2,5‐dihydroxyphenyl)‐1‐oxobutan‐3‐yl acetate (1) and four known metabolites, 1‐(2,5‐dihydroxyphenyl)‐2‐buten‐1‐one (2), 3,7‐dimethyl‐1,8‐dihydroxy‐6‐methoxyisochroman (3), modiolides A (4) and B (5). Their chemical structures were identified based on 1D, 2D NMR, and MS spectroscopic analysis and comparison with the data reported previously in the literature. All the isolated compounds were reported for the first time from the genus Paraconiothyrium.

Anti‐inflammatory metabolites from a marine sponge‐associated fungus Aspergillus sp. IMBC‐FP2.05

“…(3), 3-chloro-2,5dihydroxybenzyl alcohol (4), and phydroxybenzaldehyde (5). It is noted that this is the first time to report the in vitro anti-inflammatory effects of compounds 1, 3, and 4.…”

“…mairei has been reported to produce the anticancer drug taxol. [3] In our continuing search for secondary metabolites from the Vietnamese marine-derived fungi, [4,5] we found that an EtOAc extract of the fungal strain Aspergillus sp. IMBC-FP2.05 displays NO inhibitory effects in LPS-stimulated RAW264.7 cells.…”

Natural ten-membered lactones: sources, structural diversity, biological activity, and intriguing future

“…PSU-F22, 81 Paraconiothyrium sp. VK-13, 6,92 and Microsphaeropsis arundinis . 93 Cephalosporolide C was found in extracts obtained from cultures of closely related Cephalosporium aphidicola ACC 3490, 94 Cordyceps militaris BCC 2816, 95 and Isaria fumosorosea ACCC 37775.…”

Secondary metabolites from a marine sponge‐associated fungus Xenomyrothecium sp. IMBC‐FP2.11

“…[7] However, chemical profile of the Xenomyrothecium genus has yet to be discovered so far. In our continuing search for secondary metabolites from the Vietnamese marinederived fungi, [8,9] we conducted a chemical investigation of a fungal strain Xenomyrothecium sp. IMBC-FP2.11 isolated from an unidentified sponge.…”