Secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids

Milstone, L. M.

doi:10.1001/archderm.129.5.648

Cited by 8 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a subsequent study, however, subjects with elevated parathyroid hormone values did not have significantly lower 25-hydroxyvitamin D values than those with normal parathyroid hormone values. 9 Despite healing of rickets and restoration of endocrine abnormalities toward normal in our patients, the skin disease did not improve after treatment with calcium or intramuscular vitamin D (cholecalciferol). This is consistent with the reported ineffectiveness of oral 1␣-hydroxyvitamin D 3 in ichthyosis.…”

Section: Discussioncontrasting

confidence: 50%

Nutritional Rickets in Ichthyosis and Response to Calcipotriene

et al. 2004

View full text Add to dashboard Cite

ABSTRACT. Nutritional rickets has occasionally been described in children with lamellar ichthyosis, but their vitamin D endocrine status has not been described. We report 3 cases of vitamin D-deficiency rickets associated with ichthyosis in African children.A 13-month-old Nigerian boy with lamellar ichthyosis had rib beading, elevated alkaline phosphatase, and rachitic changes on radiographs. His rickets did not resolve with calcium therapy, and his 25-hydroxyvitamin D level was low. His rickets resolved with parenteral vitamin D treatment, but his skin did not improve. Topical 0.005% calcipotriene (an analog of 1,25-dihydroxyvitamin D that has been useful in treating adults with psoriasis) was similarly ineffective in improving the child's skin condition.An 8-year-old Nigerian boy with life-long skin findings consistent with lamellar ichthyosis had windswept deformity of the legs with rib beading and enlargement of the wrists and ankles. Radiographs showed active rickets, and the boy had an elevated alkaline phosphatase level and a decreased calcium level. Before knowing that his 25-hydroxyvitamin D level was low, he was treated with calcium and showed radiologic improvement. The skin did not improve with resolution of the rickets but did improve with unilateral topical application of 0.005% calcipotriene.A

show abstract

Section: Discussioncontrasting

confidence: 50%

Nutritional Rickets in Ichthyosis and Response to Calcipotriene

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The increased serum levels of PTH in some patients with disorders of keratinization (ichthyosis and pityriasis rubra pilaris) described by Milstone et al (6,7), are consistent with our findings. In these studies, the authors postulated that a combination of different factors (low vitamin D levels, loss of calcium through the skin and therapy with retinoids) may stimulate secretion of PTH and concluded that the exact significance of this finding remains to be elucidated.…”

Section: Discussionsupporting

confidence: 93%

“…These authors also reported a larger group of patients with ichthyosis and concluded that the elevated serum PTH levels are not due to vitamin D ingestion or treatment with retinoids. The significance of these findings remains to be established (7). As in our case, the elevation of PTH serum levels was not secondary to parathyroid adenoma.…”

supporting

confidence: 44%

Serum Levels of Parathyroid Hormone and Parathyroid‐related Peptide in Psoriasis

Regaña¹,

Ezquerra²,

Millet³

2005

Acta Dermato-Venereologica

View full text Add to dashboard Cite

Psoriasis is a common skin disorder that may be triggered by hormonal disturbances, among other factors. Some studies have demonstrated an elevation of serum parathyroid hormone (PTH) levels in psoriasis and several other diseases of keratinization of unknown aetiology. PTH-related peptide (PTH-rp), on the other hand, is a potent inhibitor of epidermal cell growth factor and is not expressed in psoriatic skin. Serum levels of this peptide have not been reported in psoriasis. Immunoassay was used to measure serum PTH and PTH-rp in 22 patients with plaque-type psoriasis before and after treatment with mometasone furoate. Results were compared with a group of 20 healthy, non-psoriatic volunteers. Serum PTH levels were significantly elevated in the psoriatic group compared with the control group (p=0.001) and were significantly reduced after treatment (p=0.01). A correlation was found between pretreatment serum PTH levels and psoriasis area and severity scores (PASI) (r=0.42; p=0.01). In contrast, serum PTH-rp levels were not different between psoriatics and controls and were not affected by treatment. These findings indicate that serum PTH concentrations reflect disease activity in patients with psoriasis.

show abstract

“…8 However, the same authors in a subsequent series of 65 patients with different types of keratinizing disorders reported secondary hyperparathyroidism in 18 patients with normal levels of 25-hydroxyvitamin D. They concluded that the secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids. 9 In a recent report of nine patients with congenital ichthyosis from Europe and North Africa, 25-hydroxyvitamin D deficiency was observed in all the cases and was more pronounced in the three patients from North Africa. 1 In our series of five patients, patients 1 and 2 had very severe manifestation of rickets, and all of them had radiological and biochemical evidence of rickets.…”

Section: Discussionmentioning

confidence: 93%

Ichthyosiform erythroderma with rickets: report of five cases

Sethuraman

Khaitan

Dash

et al. 2007

British Journal of Dermatology

View full text Add to dashboard Cite

We describe five children with ichthyosis and rickets. The association of ichthyosis and rickets is very rare. Four children had lamellar ichthyosis and one child had nonbullous ichthyosiform erythroderma/psoriasis with atopy. All had biochemical and radiological evidence of rickets. Three had clinically evident rickets, of whom two had very severe skeletal deformities. Such a severe skeletal involvement due to rickets in association with ichthyosis is exceptionally rare. We suggest that children with severe ichthyosis, in particular those with pigmented skin, need to be evaluated for rickets, especially in developing countries where there is a background prevalence of vitamin D deficiency.

show abstract

Secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids

Cited by 8 publications

References 0 publications

Nutritional Rickets in Ichthyosis and Response to Calcipotriene

Nutritional Rickets in Ichthyosis and Response to Calcipotriene

Serum Levels of Parathyroid Hormone and Parathyroid‐related Peptide in Psoriasis

Ichthyosiform erythroderma with rickets: report of five cases

Contact Info

Product

Resources

About