Secondary cutaneous mucinosis with systemic lupus erythematosus. A case presentation and review of the literature

Abstract

A patient had papular and nodular cutaneous deposits of mucin and cutaneous and systemic manifestations of lupus erythematosus (LE). Since many of the mucinous deposits occurred at sites that were clinically free of skin lesions of LE, we considered initially that the patient had both LE and papular mucinosis. However, after a review of the English literature and further study of the patient, it seemed more likely that the papular and nodular deposits of mucin were secondary to LE and not a previously unreported simultaneous occurrence of the two diseases in the same patient. To our knowledge, this is the third case report of a patient with papular and nodular cutaneous mucinosis secondary to LE. In addition to the case report, this article is concerned with a discussion of cutaneous mucinosis in LE and other "collagen vascular" diseases.

Papulonodular Mucinosis Associated with Subacute Cutaneous Lupus erythematosus

“…However, in most cases, mucin deposition is rarely present in sufficient quantity to produce lesions that are clinically detectable in these diseases [3, 4]. Although recognized as early as 1954 by Gold [5], fewer than 40 patients with papulonodular mucinosis associated with LE have been described in the literature [3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32]. In 79% of the patients, such skin lesions were associated with systemic LE (SLE), and in 21% with discoid LE (DLE).…”

Cutaneous Mucinosis in a Strain of Brown–Egg Laying Chickens

“…9 In humans, secondary mucin deposition has been observed in connective tissue injury or diseases of many types, including lupus erythematosus, hypertrophic scarring, dermatomyositis, scleroderma, and actinic elastosis. 6,12,27 In dogs, secondary mucinosis has been observed in pyoderma, allergy, eosinophilic skin disease, lupus erythematosus, acromegaly, dermatomyositis, and mast cell tumor. 8,29,30 An unusual case of generalized cutaneous mucinosis characterized by multiple dermal swellings on the head, back, elbows, hocks, and digital pads occurred in association with thyroid carcinoma in a dog.…”