Secondary amyloidosis with severe autonomic dysfunctions

Arima, Toshiyuki; Ando, Yukio; Ando, Eiko; Okamura, R; Sakashita, Naomi; Tanaka, Yoshiya; Uchino, Makoto; Ando, Masayuki

doi:10.1016/0165-1838(94)00147-c

Cited by 11 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this type of FAP, peripheral autonomic nerves are impaired first, before the sensory and motor nerves [ 23]. It is also well documented that autonomic dysfunction in the visceral organs and autonomic neuropathy occasionally occur in patients with AL amyloidosis, but are extremely rare in secondary amyloidosis [ 24]. In these two types of amyloidosis, associations of amyloid with nerves are not usually seen.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30)

Yoshimatsu

Ando²,

Terazaki

et al. 1998

Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

Objectives. To evaluate the characteristic changes in the gastrointestinal tract in familial amyloidotic polyneuropathy (FAP) (Met30), both fibre gastroscopy and colonoscopy studies were performed in FAP (Met30) patients. Microscopic changes were also examined in autopsied and biopsied materials from patients with FAP, and compared with data from autopsied samples from patients with AL amyloidosis, and secondary amyloidosis patients. Design. Endoscopic and histopathological study. Setting. Kumamoto University Hospital, Kumamoto, Japan. Subjects. Nine patients with FAP (Met30) underwent fibre gastroscopy and colonoscopy. Six autopsied and 23 biopsied gastrointestinal samples from FAP patients, four from autopsied amyloidosis (including two myeloma associated form), and two from autopsied secondary amyloidosis patients were examined for histopathological study. Main outcome measures. Fibre gastroscopy and colonoscopy were employed for macroscopic study. Congo red and H-E staining were performed for histopathological study. Macroscopic changes in the gastrointestinal tract and microscopic differences in the amyloid distribution pattern were compared between the different types of amyloidosis. Results. Fibre gastroscopy and colonoscopy for nine FAP patients revealed that four showed a fine granular appearance in the duodenum, three showed lack of lustre, and two showed mucosal friability in the gastrointestinal tract; however, no macroscopic abnormality was observed in four other FAP patients. Histopathological examination of tissue from FAP patients revealed that, although a small amount of amyloid was recognized in the submucosa perivascular layer, a significant amount of amyloid was seen in and around the nerves of the gastrointestinal tract, but very little in Auerbach's nerve plexus. In total, the amount of deposited amyloid in the tissues was small compared with that in other types of systemic amyloidosis, such as AL and secondary amyloidosis. Conclusion. These results suggest that the major reason why FAP patients show such severe gastrointestinal symptoms, compared with other types of systemic amyloidosis, may be because of the deposition of a significant amount of amyloid in the nerves in the gastrointestinal tract.

show abstract

Section: Introductionmentioning

confidence: 99%

Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30)

Yoshimatsu

Ando²,

Terazaki

et al. 1998

Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The last hypothesis, linking amyloidosis to dysautonomia in RA, is supported by a few previous reports. 4,5 An uncommon case with severe dysautonomia as a consequence of amyloid deposit infiltrating the nervous system has been described. 1 The present case is the first documented to have the SAA1.3 allele, which is a remarkable risk factor for amyloidosis in Japanese RA.…”

Section: Discussionmentioning

confidence: 99%

Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis

Nakamura¹,

Tomoda²,

Tsukano³

et al. 2004

Mod Rheumatol

View full text Add to dashboard Cite

“…Esta participação pode se manifestar por disfunção autonômica cardiocirculatória e disfunção glandular. São manifestações clínicas destas disfunções: hipotensão ortostática, diminuição do coeficiente de variação do intervalo R-R no ECG, diminuição do acúmulo de [123I] metaiodobenzilguanidina (MIBG) no coração, redução da lágrima, de secreções salivares e anidrose 7 . A disfunção autonômica cardiocirculatória ocorreu no caso descrito, com certeza, pela tendência progressiva de queda da pressão arterial sistêmica, sem resposta a altas doses de catecolaminas utilizadas na fase terminal.…”

Section: Discussionunclassified

Comprometimento cardíaco na amiloidose sistêmica. Diagnóstico in vivo

Mendes¹,

Évora²,

Mendes³

et al. 1998

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

A amiloidose cardíaca é causada por depósito amilóide derivado de diferentes proteínas plasmáticas humanas, sendo mais comum no idoso. Este depósito amilóide pode levar a distúrbio da condução cardíaca, cardiomiopatia restritiva, baixo débito cardíaco e comprometimentos atriais isolados 1 . Entre as cardiomiopatias causadas por distúrbios do metabolismo protéico, a amiloidose, ainda que rara, pode ser mencionada em primeiro lugar.Descrevemos o caso de um paciente com amiloidose sistêmica primária, comprometendo o coração, o fígado e, provavelmente, os pulmões. Ressaltam-se os aspectos fisiopatológicos, clínicos e a relativa raridade do diagnósti-co in vivo. Discutem-se, ainda que limitados, os aspectos terapêuticos relacionados aos problemas cardíacos. Relato do CasoHomem de 42 anos apresentou história de tosse seca em agosto/95. Investigação clínica pelo estudo radiológico do tórax, várias pesquisas de escarro, teste Mantoux para tuberculose, além de outros exames laboratoriais rotineiros, Fig. 1 -A) Radiografia do tórax evidenciando cardiomegalia à custa das cavidades direitas; B) eletrocardiograma mostrando, hemibloqueio anterior esquerdo, alterações difusas da repolarização ventricular e áreas inativas ântero-septal e lateral alta, além de baixa voltagem do complexo QRS.

show abstract

Secondary amyloidosis with severe autonomic dysfunctions

Cited by 11 publications

References 8 publications

Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30)

Endoscopic and pathological manifestations of the gastrointestinal tract in familial amyloidotic polyneuropathy type I (Met30)

Gustatory sweating due to autonomic neuropathy in a patient with amyloidosis secondary to rheumatoid arthritis

Comprometimento cardíaco na amiloidose sistêmica. Diagnóstico in vivo

Contact Info

Product

Resources

About