Secondary amyloidosis due to Schistosoma mansoni infection.

Omer, H O; Wahab, Siswanto

doi:10.1136/bmj.1.6006.375

Cited by 19 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Amyloidosis was a fairly common glomerulopathy in this survey with a prevalence ranging from 6.1% to 10.3% of all glomerular lesions. According to other reports, it may be attributed to chronic infection as tuberculosis in India (20), schistosomiasis in Egypt (21,22), or to familial Mediterranean fever in North Africa (23,24).…”

Section: Results and Commentsmentioning

confidence: 99%

Overview: End‐Stage Renal Disease in the Developing World

Barsoum

2002

Artificial Organs

View full text Add to dashboard Cite

Although the vast majority of patients with end-stage renal disease (ESRD) worldwide live in what is called the developing world, little is known about its epidemiology and management. With the current paucity of credible and adequately representative registries, it is justified to resort to innovative means of obtaining information. In this attempt, world-renowned leading nephrologists in 10 developing countries collaborated in filling a 103-item questionnaire addressing epidemiology, etiology, and management of ESRD in their respective countries on the basis of integrating available data from different sources. Through this joint effort, it was possible to identify a number of important trends. These include the expected high prevalence of ESRD, despite the limited access to renal replacement therapy, and the dependence of prevalence on wealth. Glomerulonephritis, rather than diabetes, remains as the main cause of ESRD with significant geographical variations in the prevailing histopathological types. The implementation of different modalities of renal replacement therapy (RRT) is inhibited by the lack of funding, although governments, insurance companies, and donations usually constitute the major sponsors. Hemodialysis is the preferred modality in most countries with the exception of Mexico where chronic ambulatory peritoneal dialysis (CAPD) takes the lead. In several other countries, dialysis is available only for those on the transplant waiting list. Dialysis is associated with a high frequency of complications particularly HBV and HCV infections. Data on HIV are lacking. Aluminum intoxication remains as a major problem in a number of countries. Treatment withdrawal is common for socioeconomic reasons. Transplantation is offered to an average of 4 per million population (pmp). Recipient exclusion criteria are minimal. Donor selection criteria are generally loose regarding tissue typing, remote viral infection, and, in some countries, blood-relation to the recipient in live-donor transplants. Cadaver donors are accepted in many countries participating in this survey. Treatment outcomes with different RRT modalities are, on the average, inferior to the internationally acknowledged standards largely due to infective and cardiovascular complications.

show abstract

Section: Results and Commentsmentioning

confidence: 99%

Overview: End‐Stage Renal Disease in the Developing World

Barsoum

2002

Artificial Organs

View full text Add to dashboard Cite

show abstract

“…Prognosis is poor. An earlier report of a favorable response to anti-schistosomal treat ment [8] could not be confirmed by repeat biopsy in another longitudinal study [9]. We have previously de scribed renal amyloidosis in schistosoma-infected ham sters [4].…”

Section: Introductionmentioning

confidence: 92%

Effect of Colchicine on Schistosoma-lnduced Renal Amyloidosis in Syrian Golden Hamsters

Sobh

Moustafa²,

Hamed³

et al. 1995

Nephron

View full text Add to dashboard Cite

Seventy Syrian golden hamsters were infected with Schistosoma haematobium, and 10 uninfected hamsters served as negative controls. Of the schistosome-infected hamsters, 10 served as positive controls (infected but untreated) and the rest (60 hamsters) received treatment. In 30 hamsters treatment was given 9 weeks after infection (before the appearance of renal amyloidosis) and in the other 30 it was given after the appearance of amyloid deposits, 15 weeks after infection. Each treatment group was subdivided into 3 groups (10 hamsters each) in which treatment was either antischistosomal alone, combined anti-schistosomal and colchicine, or colchicine alone. Eighteen weeks after infection half of the animals in each group were sacrificed, while the rest were sacrificed 24 weeks after infection. Kidney specimens were evaluated semiquantitatively for renal amyloid deposits. Significant reductions in renal amyloid deposits and proteinuria were observed when combined treatment was given. This was nearly complete with early treatment and only partial when treatment was given late. When colchicine was given alone, a partial but significant reduction in proteinuria with no recognizable effect on renal amyloid deposits was observed. We conclude that colchicine is effective for the prevention and cure of schistosome-related renal amyloidosis in golden hamsters.

show abstract

“…The most frequently reported parasitic cause of AA amyloidosis is schistosomiasis, 54‐59 but evidence of this remains highly anecdotal.…”

Section: Infections Associated With Aa Amyloidosismentioning

confidence: 99%

“…Several cases of nephrotic syndrome disappeared under appropriate treatment of the causal infection, but relapse can occur with reinfection 4,34,54,100,106,152‐155 . In rare cases, a decrease or even the disappearance of amyloid deposits on repeated biopsies has been shown 11,55,69,154‐156 …”

Section: Frequency Of Infections As An Aetiological Factor In Aa Amyloidosismentioning

confidence: 99%

Infections and AA amyloidosis: An overview

et al. 2021

View full text Add to dashboard Cite

Background Amyloidoses are a heterogeneous group of systemic diseases characterised by extracellular accumulation of insoluble amyloid fibrils derived from unfolded proteins. Inflammatory (AA) amyloidosis can complicate various inflammatory disorders that are associated with a sustained acute phase response and serum amyloid A (SAA) protein overproduction. Chronic infections were the first recognised cause of amyloidoses. However, with the better management of underlying diseases, the frequency of AA amyloidosis is decreasing. Purpose The aim of this overview was to discuss the several infections associated with AA amyloidosis and the relative frequency of infections as aetiological factors. Methods A search of the literature was performed using the PubMed database using the MeSH terms “Amyloidosis” and “Infections,” from inception to December 31st, 2019. Articles written in other languages than English or French were excluded. Results The frequency of AA amyloidosis secondary to infections decreased from more than 50% to less than 20% after the 2000s, with a parallel increase in the frequency of AA amyloidosis secondary to inflammatory diseases and to an unknown cause. Conclusion Whereas new antibiotics have been developed and sanitary conditions are better, infections still represent 5%‐30% of the causes of AA amyloidosis, including in developed countries. These data argue for better screening of chronic infections to prevent AA amyloidosis and the development of new strategies to manage recurrent infections.

show abstract

Secondary amyloidosis due to Schistosoma mansoni infection.

Cited by 19 publications

References 5 publications

Overview: End‐Stage Renal Disease in the Developing World

Overview: End‐Stage Renal Disease in the Developing World

Effect of Colchicine on Schistosoma-lnduced Renal Amyloidosis in Syrian Golden Hamsters

Infections and AA amyloidosis: An overview

Contact Info

Product

Resources

About