Second primary tumors in patients with head and neck squamous cell carcinoma

Jones, A. S.; Morar, Pradeep; Phillips, David; Field, John K.; Husband, David; Helliwell, Tim

doi:10.1002/1097-0142(19950315)75:6<1343::aid-cncr2820750617>3.0.co;2-t

Cited by 306 publications

(234 citation statements)

References 43 publications

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“…The 3-year OS rate for patients with RIS in our series (32.4%) was within the lower end of the wide range reported previously (8%-60% at 5 years). [3][4][5][6][7][8][9][10][11][12][13]34 The best survival outcome was reported by Tabone et al, 35 who reported that the OS and eventfree survival rates for 23 patients with radiation-related osteosarcoma at 8 years were 50% and 41%, respectively.…”

Section: Radiation-induced Sarcoma In Npc/xi Et Almentioning

confidence: 99%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

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BACKGROUND:The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METH-ODS: Institutional electronic medical records of patients with NPC who received definitive radiotherapy between February 1964 and 2003 were reviewed. Fifty-three patients who developed RIS and fulfilled the study criteria were included. RESULTS: The median follow-up after a diagnosis of RIS was 15.5 months (range, 0.4-90.3 months), and the median latency between radiotherapy for NPC and an RIS diagnosis was 9.3 years (range, 3.2-26.6 years). Fibrosarcoma was the most frequent histologic type observed, followed by osteosarcoma, and malignant fibrous histiocytoma. The 3-year overall survival (OS) rate for 49 patients who received treatment was 32.4%, and the median survival was 21.2 months (95% confidence interval, 8.7-33.8 months). The median OS was 41.3 months, 8.4 months, and 11 months for the complete resection group, the incomplete resection group, and the chemotherapy group, respectively (P<.0001). The only independent predictive factor that was associated with better OS was complete surgical resection. CONCLUSIONS: This retrospective study confirmed the rarity and poor prognosis of RIS in patients with NPC. Complete surgical resection was a significant prognostic factor for survival. The authors concluded that long-term follow-up is necessary for the early detection of RIS in patients with NPC. Cancer 2010;116:5479-86.

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Section: Radiation-induced Sarcoma In Npc/xi Et Almentioning

confidence: 99%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

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“…Second cancers predominantly affect the head and neck area, oesophagus or the lung [1,2]. The prevalence of a second SCC in cadaver dissection studies ranges between 3.7% and 15.5% [3,4].…”

Section: Introductionmentioning

confidence: 99%

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Strobel

Haerle

Stoeckli

et al. 2009

Eur J Nucl Med Mol Imaging

117

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Purpose The aim of the study was to evaluate 18 F-FDG-PET/CT for the detection of synchronous primaries at initial staging of patients with head and neck squamous cell carcinoma (HNSCC). Methods FDG-PET/CT images acquired between March 2001 and October 2007 in 589 consecutive patients (147 women, 442 men; mean age 61.5 years, age range 32-97 years) with proven HNSCC were reviewed for the presence of synchronous primaries. Cytology, histology and/or clinical and imaging follow-up served as reference standard.Results FDG-PET/CT showed 69 suspected synchronous primaries in 62 patients of which 56 were finally confirmed in 44 patients. Of the 56 second cancers, 46 (82%) were found in the aerodigestive tract in the following locations: lung (26, 46%), head and neck (15, 17%), oesophagus (5, 9%). Ten second cancers (18%) were located outside the aerodigestive tract (colon, five; stomach, lymphoma, breast, thymus and kidney, one each). Six patients had three synchronous primaries and three patients had four synchronous cancers. Nine synchronous cancers were not detected by PET/CT (four head and neck, two lung, two oesophageal, one gastric). False-positive PET/CT findings were mainly related to benign FDG uptake in the intestine due to benign or precancerous polyps or physiological FDG uptake in other head and neck regions. Overall the prevalence of synchronous second primaries according to the reference standard was 9.5%, of which 84% were detected with FDG-PET/CT. In 80% of the patients, therapy was changed because of the detection of a synchronous primary. Conclusion FDG-PET/CT detects a considerable number of synchronous primaries (8.0% prevalence) at initial staging of patients with HNSCC. Synchronous cancers were predominantly located in the aerodigestive tract, primarily in the lung, head and neck and oesophagus. Detection of second primaries has an important impact on therapy. PET/ CT should be performed before panendoscopy.

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“…Among HNSCC patients, the frequency of SPT occurrence ranges from 12 to 30% with a constant rate of 2-3% per year for patients who survive for more than 10 years. (1)(2)(3) The first tumor is responsible for 15% of patient deaths, whereas the second tumor is the cause of death in 71% of cases. Squamous cell carcinoma is the predominant histological type of the second tumor.…”

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confidence: 99%

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene

Ziółkowska

Mosor

Wierzbicka³

et al. 2007

Cancer Science

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The high incidence of multiple primary tumors (MPT) is a significant problem in head and neck tumor treatment. Recent studies suggest that carriers of heterozygous mutations in the NBS1 gene have an increased risk of malignant tumor development. The aim of our research was to assess the frequency of NBS1 mutations in patients with larynx cancer only (LC) and with MPT. The MPT group consisted of patients with one cancer localized to the larynx (primary or second) and another at another site. DNA from 175 patients with LC and 93 patients with MPT was analyzed using the single-strand conformation polymorphism method and direct sequencing. We found nine carriers of the I171V mutation among these 268 cancer patients and only one carrier among 500 population controls (0.2%). Four carriers of the I171V mutation were detected among 175 LC patients (2.3%) and five among 93 patients with MPT (5.4%). The frequencies of the I171V mutation carriers in LC and MPT patients were significantly higher than in controls (odds ratio D espite recent advances in the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC), the survival rate of patients with these tumors is not improving. One of the reasons for this is the frequent development of second primary tumors (SPT). Among HNSCC patients, the frequency of SPT occurrence ranges from 12 to 30% with a constant rate of 2-3% per year for patients who survive for more than 10 years.[(1-3) The first tumor is responsible for 15% of patient deaths, whereas the second tumor is the cause of death in 71% of cases. Squamous cell carcinoma is the predominant histological type of the second tumor. (4) In the etiology of multiple primary tumors (MPT) of the head and neck, tobacco and alcohol abuse ('condemned mucosa theory') are essential but are not the only causal factors.(5) It is supposed that genetic factors play a great role in the occurrence of the first tumor and, in addition, predispose the patient to the development of a second primary tumor. Because of reduced DNA repair capacity in patients who had two or more independent malignancies, (6) it has been suggested that alterations in DNA repair genes may play a significant role in head and neck tumor development.The NBS1 gene belongs to a group of double-strand break repair genes and is located on chromosome band 8q21.3. (7)(8)(9) Biallelic mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome (NBS, OMIM 251260), classified to a group of chromosomal instability syndromes. NBS is a rare autosomal recessive disorder, occurring mainly in central and eastern Europe.(10) The most common is the homozygous 657del5 mutation, observed in 90% of NBS patients. The protein product of the NBS1 gene, nibrin (p95, NBS1), is a member of the MRE11-RAD50-nibrin complex, (7) which is involved in DNA double-strand break repair by homologous recombination or non-homologous end joining, meiotic recombination and the DNA damage response. (7,11) The MRE11-RAD50-nibrin complex is also required for activation of the damage c...

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Second primary tumors in patients with head and neck squamous cell carcinoma

Cited by 306 publications

References 43 publications

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Head and neck squamous cell carcinoma (HNSCC) – detection of synchronous primaries with 18F-FDG-PET/CT

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene

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