Journal of Cell Biology volume 216, issue 11, P3639-3653 2017 DOI: 10.1083/jcb.201704036 View full text
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Shuai Wang, Chien-I Yang, Shu-ou Shan

Abstract: Proteins are thought to be delivered to the bacterial plasma membrane cotranslationally by signal recognition particle or posttranslationally by SecA. Wang et al. identify a new membrane protein–targeting pathway in bacteria in which SecA cotranslationally recognizes and targets the inner membrane protein RodZ, which harbors an internal transmembrane domain.