Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls

Stewart, M. E.

doi:10.1001/archderm.128.10.1345

Cited by 23 publications

(15 citation statements)

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“…In a longitudinal study of acne and hormonal analysis, Stewart et al [26] concluded that girls with severe acne present a statistically significantly earlier menarche (12.2 years) compared to those with moderate and mild disease (12.4 and 12.7 years). They also concluded that the number of comedones were predictive for the severity of late inflammatory acne.…”

Section: Prepubertal Acnementioning

confidence: 99%

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Acne in Infancy and Acne Genetics

2003

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Acne is a disease that can be seen in the first year of age, early childhood, prepubertal age and puberty. Neonatal acne is due mainly to considerable sebum excretion rate, and infantile acne because of high androgens of adrenal origin in girls and of adrenal and testes in boys. These pathogenic mechanisms are characteristic in these ages. Important factors like early onset of comedones and high serum levels of dehydroepiandrosterone sulfate are predictors of severe or long-standing acne in prepubertal age. Hereditary factors play an important role in acne. Neonatal, nodulocystic acne and conglobate acne has proven genetic influences. Postadolescent acne is related with a first-degree relative with the condition in 50% of the cases. Chromosomal abnormalities, HLA phenotypes, polymorphism of human cytochrome P-450 1A1 and MUC1 gene are involved in the pathogenesis of acne. Several other genes are being studied.

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Section: Prepubertal Acnementioning

confidence: 99%

“…This group also showed higher levels of DHEAS early in life. A correlation between DHEAS, sebum production and free testosterone was found in severe comedonal acne [26]. …”

Section: Prepubertal Acnementioning

confidence: 99%

Acne in Infancy and Acne Genetics

2003

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“…Although in multiple cross-sectional analysis testosterone was not significantly higher in the acne-prone group, using a longitudinal statistical analysis tool, free testosterone was also found to be significantly correlated with acne, primarily in the older girls. Complementary studies of the relationship of DHEAS to sebum production (ratio of wax esters to cholesterol and cholesterol esters) similarly showed a high correlation between the two parameters in girls at all stages of puberty [5]. …”

Section: Introductionmentioning

confidence: 99%

A Review of Infantile and PediatricAcne

Lucky¹

1998

Dermatology

110

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Acne occurs primarily in the first year of life and at puberty. Neonatal and infantile acne may reflect the relatively high androgens from the adrenal in girls and the adrenal and testes in boys characteristic of this age. Early in puberty, acne in boys and girls is primarily comedonal and midfacial. The best predictors of severe acne are early onset of comedones and serum levels of dehydroepiandrosterone sulfate. Early recognition and therapy of acne may prevent scarring and psychological stress.

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“…The development of early acne in the prepubertal period has been associated with elevated serum levels of dehydroepiandrosterone sulfate (DHEAS), a precursor of testosterone [9, 10]. For example, acne occurs near the time of puberty.…”

Section: Androgens and Sebum Productionmentioning

confidence: 99%

“…For example, acne occurs near the time of puberty. In fact, investigators have demonstrated that acne begins to develop at the time of adrenarche when the adrenal gland begins to produce large quantities of DHEAS [9, 10]. This hormone can serve as a precursor to the production of more potent androgens within the sebaceous gland.…”

Section: Androgens and Sebum Productionmentioning

confidence: 99%

Update and Future of Hormonal Therapy in Acne

Thiboutot

Chen

2003

Dermatology

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Hormonal therapy is an important component in the treatment of women with acne who may or may not have elevated serum androgens. The mainstays of hormonal therapy include oral contraceptives and antiandrogens such as cyproterone acetate, flutamide or spironolactone. Recent research over the past several years has unraveled some of the details regarding the way that the skin and sebaceous glands synthesize and metabolize hormones. The knowledge gained from this work may provide an impetus for future drug discovery in the hormonal treatment of acne and lead to improvements in the care of our patients with acne.

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Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls

Cited by 23 publications

References 0 publications

Acne in Infancy and Acne Genetics

Acne in Infancy and Acne Genetics

A Review of Infantile and PediatricAcne

Update and Future of Hormonal Therapy in Acne

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