Seaweed Vitamins as Nutraceuticals

Škrovánková, Soňa

doi:10.1016/b978-0-12-387669-0.00028-4

Cited by 82 publications

(38 citation statements)

References 42 publications

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“…Thus, focusing on new drugs of natural products that contribute to prevention strategies and treatment are very important [23]. Many vitamins from seaweed are essential due to its biochemical functions and antioxidant activity and also as health benefits such as decreasing of blood pressure, prevention of cardiovascular diseases, and reducing the risk of cancer [24].…”

Section: Discussionmentioning

confidence: 99%

Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Gambato¹,

Baroni²,

Garcia³

et al. 2014

ABC

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Marine algae have been used as food since ancient times and today are consumed as a regular part of the diet. In this study, we hypothesized that H. grandifolius phlorotannins-enriched extract exerts cytotoxic selective effects against tumor cell lines promoting cell death trough apoptosis mechanisms. The aim of the present study is to characterize chemically and investigate the selective cytotoxic effect of the H. grandifolius extract on epithelial tumour cell lines (A375, A549, Hep-2, HeLa) compared to non-malignant cell line (Hek-293), and evaluate possible molecular mechanisms involved in the programmed cell death pathway. High-resolution directly-infusion mass spectrometry (HR-DIMS) analysis with electrospray ionization (ESI) was performed in positive and negative mode. Cytotoxicity was evaluated through colorimetric assay and morphological altera-* Corresponding author. G. Gambato et al. 99tions were observed in giemsa stained cells after extract treatment. Apoptosis was further evaluated by annexin V staining. Spectra showed peaks m/z between 370 and 430 and molecular formula was defined upon isotopic ratio. Extract showed selectivity to the non-tumor line with enhanced cytotoxicity in tumor cells according to the concentration and exposure time. After 72 h treatment, the HeLa strain was more susceptible to the extract, followed by lines Hep2, A375 and A549. Morphological changes by giemsa were observed after increased doses of extracts and staining for annexin V showed majority of tumor cells at early stages of the apoptotic process. Here, selective anti-tumor activity of extract taken from the alga H. grandifolius was able to suppress proliferation and promote apoptosis-mediated cell death with induction of initial stages of apoptosis in different cell lines.

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Section: Discussionmentioning

confidence: 99%

Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Gambato¹,

Baroni²,

Garcia³

et al. 2014

ABC

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“…Part of the variability may lie in the sample processing methods (Skrovankova 2011) as observed for other phytochemicals (Ling et al 2015); for example, analysis of freeze-dried and oven dried samples of Sargassum hemiphyllum yielded substantially different vitamin C contents (Chan et al 1997). But differences also can be due to environmental and seasonal factors.…”

Section: Vitaminsmentioning

confidence: 99%

Algae as nutritional and functional food sources: revisiting our understanding

et al. 2016

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Global demand for macroalgal and microalgal foods is growing, and algae are increasingly being consumed for functional benefits beyond the traditional considerations of nutrition and health. There is substantial evidence for the health benefits of algal-derived food products, but there remain considerable challenges in quantifying these benefits, as well as possible adverse effects. First, there is a limited understanding of nutritional composition across algal species, geographical regions, and seasons, all of which can substantially affect their dietary value. The second issue is quantifying which fractions of algal foods are bioavailable to humans, and which factors influence how food constituents are released, ranging from food preparation through genetic differentiation in the gut microbiome. Third is understanding how algal nutritional and functional constituents interact in human metabolism. Superimposed considerations are the effects of harvesting, storage, and food processing techniques that can dramatically influence the potential nutritive value of algal-derived foods. We highlight this rapidly advancing area of algal science with a particular focus on the key research required to assess better the health benefits of an alga or algal product. There are rich opportunities for phycologists in this emerging field, requiring exciting new experimental and collaborative approaches.Electronic supplementary materialThe online version of this article (doi:10.1007/s10811-016-0974-5) contains supplementary material, which is available to authorized users.

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“…The beneficial health effects of the vitamin B complex (e.g., choline, inositol) in laver include the synthesis of major nutritional factors (i.e., carbohydrate, protein, and lipid), anti-cancer effects, and enhanced immunomodulation [18,56,85,86]. Lavers produce exceptional quantities of VitB 12 and thus can be used to counter the deficiency of VitB 12 (e.g., methylmalonic acidemias) in vegan diets by the consumption of laver [86][87][88]. The bioavailability of VitB 12 was also confirmed by increases in the hepatic VitB 12 level of rats by the intake of laver [38,89] and by the release of VitB 12 from laver after human consumption simulated through in vitro gastrointestinal digestion experiments [41].…”

Section: Health Functionality Major Components Linked To Health Functmentioning

confidence: 99%

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Cho

Rhee

2019

Marine Drugs

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The growing interest in laver as a food product and as a source of substances beneficial to health has led to global consumer demand for laver produced in a limited area of northeastern Asia. Here we review research into the benefits of laver consumption and discuss future perspectives on the improvement of laver product quality. Variation in nutritional/functional values among product types (raw and processed (dried, roasted, or seasoned) laver) makes product-specific nutritional analysis a prerequisite for accurate prediction of health benefits. The effects of drying, roasting, and seasoning on the contents of both beneficial and harmful substances highlight the importance of managing laver processing conditions. Most research into health benefits has focused on substances present at high concentrations in laver (porphyran, Vitamin B 12 , taurine), with assessment of the expected effects of laver consumption. Mitigation of chemical/microbiological risks and the adoption of novel technologies to exploit under-reported biochemical characteristics of lavers are suggested as key strategies for the further improvement of laver product quality. Comprehensive analysis of the literature regarding laver as a food product and as a source of biomedical compounds highlights the possibilities and challenges for application of laver products.

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Seaweed Vitamins as Nutraceuticals

Cited by 82 publications

References 42 publications

Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Algae as nutritional and functional food sources: revisiting our understanding

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

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Seaweed Vitamins as Nutraceuticals

Cited by 82 publications

References 42 publications

Brown Algae &lt;i&gt;Himantothallus grandifolius&lt;/i&gt; (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Brown Algae &lt;i&gt;Himantothallus grandifolius&lt;/i&gt; (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Algae as nutritional and functional food sources: revisiting our understanding

Health Functionality and Quality Control of Laver (Porphyra, Pyropia): Current Issues and Future Perspectives as an Edible Seaweed

Contact Info

Product

Resources

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Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells

Brown Algae <i>Himantothallus grandifolius</i> (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells