Seated-Immobility Thromboembolism Syndrome Complicating Coronavirus Disease 2019 Outbreak Quarantine

Ali, Abdulla; Omore, Ibrahim; Asare, Louisa; Gabani, Mohanad; Riaz, Muhammad Usman

doi:10.1016/j.chest.2020.08.1453

Cited by 6 publications

(5 citation statements)

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“…Hemostatic and inflammatory modifications are common in severe manifestations of COVID-19, and both the bedridden status and critical illness may constitute a prothrombotic milieu predisposing to venous and arterial thrombosis [ 62 ]. Hypercoagulative responses may result from specific interactions between host defense mechanisms and the coagulation system [ 63 ].…”

Section: Antocoagulative Therapy In Covid-19mentioning

confidence: 99%

Immune reactivity during COVID-19: Implications for treatment

Napoli

Benincasa

Criscuolo³

et al. 2021

Immunology Letters

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Section: Antocoagulative Therapy In Covid-19mentioning

confidence: 99%

Immune reactivity during COVID-19: Implications for treatment

Napoli

Benincasa

Criscuolo³

et al. 2021

Immunology Letters

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“…52,[76][77][78][79][80] In severely infected patients, immobility under conditions of quarantine or hospitalization is another predisposing factor of thrombosis. 81,82 Modification of the equilibrium between clot formation and degradation in favor of hypercoagulability and hypofibrinolysis, impaired endothelial function, platelet hyperactivation, and excessive immune response are emerging as major contributors to the thrombotic complications. Thus, using a multipurposed therapeutic approach beyond the regular anticoagulants can better prepare for fighting the disease (►Table 1).…”

Section: Pathophysiology Of Covid-19-associated Coagulopathymentioning

confidence: 99%

The Impact of SARS-CoV-2 Infection on Blood Coagulation and Fibrinolytic Pathways: A Review of Prothrombotic Changes Caused by COVID-19

Bahraini

Dorgalaleh

2021

Semin Thromb Hemost

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The cardinal pathology of coronavirus disease 2019 (COVID-19) is a primary infection of pulmonary tract cells by severe acute respiratory syndrome coronavirus 2, provoking a local inflammatory response, often accompanied by cytokine storm and acute respiratory distress syndrome, especially in patients with severe disease. Systemic propagation of the disease may associate with thrombotic events, including deep vein thrombosis, pulmonary embolism, and thrombotic microangiopathy, which are important causes of morbidity and mortality in patients with COVID-19. This narrative review describes current knowledge of the pathophysiological mechanisms of COVID-19-associated coagulopathy, with focus on prothrombotic changes in hemostatic mediators, including plasma levels of clotting factors, natural anticoagulants, components of fibrinolytic system, and platelets. It will also highlight the central role of endothelial cells in COVID-19-associated coagulopathy. This narrative review discusses also potential therapeutic strategies for managing thrombotic complications. Awareness by medical experts of contributors to the pathogenesis of thrombotic events in COVID-19 is imperative to develop therapeutics not limited to regular anticoagulants. Instituting cooperation among medical personnel and researchers may lessen this novel virus' impact now, and in the event of recurrence.

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“…As illustrated by this case, adverse patient outcomes like DVT can be traced directly to the effects of #StayAtHome directives [9]. Next to seated immobility in relation to travel, work, or computer gaming, a sedentary lifestyle due to COVID-19 restrictions could present as another cause of seated immobility thromboembolism (SIT) [9,10]. Therefore, effective prevention and protection concepts are indispensable during the COVID-19 pandemic, especially for vulnerable and older patients [11][12][13].…”

Section: Discussionmentioning

confidence: 98%

COVID-19 #StayAtHome Restrictions and Deep Vein Thrombosis: Case Report (Preprint)

Blum¹,

Abdelwahed²,

Spiess³

et al. 2020

Preprint

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BACKGROUND The COVID-19 pandemic triggered countermeasures like #StayAtHome initiatives, which have changed the whole world. Despite the success of such initiatives in limiting the spread of COVID-19 to #FlattenTheCurve, physicians are now confronted with the adverse effects of the current restrictive pandemic management strategies and social distancing measures. OBJECTIVE We aim to draw attention to the particular importance and magnitude of what may be the adverse effects of COVID-19–related policies. METHODS We herein report a case of an otherwise healthy 84-year-old woman with deep vein thrombosis (DVT) due to COVID-19–related directives. #StayAtHome policies and consequential social isolation have diminished our patient’s social life and reduced her healthy movement behaviors. The patient spent long hours in a seated position while focusing on the intensive flow of media information regarding the pandemic. RESULTS Reduced mobility due to preventive social isolation during the COVID-19 pandemic was the only identified cause of the DVT. CONCLUSIONS While evaluating the effect of the COVID-19 pandemic and governmentally implemented containment measures, including social isolation and mobility reduction, adverse events should be considered. Digital approaches might play a crucial role in supporting public health.

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Seated-Immobility Thromboembolism Syndrome Complicating Coronavirus Disease 2019 Outbreak Quarantine

Cited by 6 publications

References 0 publications

Immune reactivity during COVID-19: Implications for treatment

Immune reactivity during COVID-19: Implications for treatment

The Impact of SARS-CoV-2 Infection on Blood Coagulation and Fibrinolytic Pathways: A Review of Prothrombotic Changes Caused by COVID-19

COVID-19 #StayAtHome Restrictions and Deep Vein Thrombosis: Case Report (Preprint)

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