Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam

Althouse, Benjamin M.; Flasche, Stefan; Minh, Le Nhat; Thiểm, Vũ Đình; Hashizume, Masahiro; Ariyoshi, Koya; Anh, Đặng Đức; Rodgers, Gail L.; Klugman, Keith P.; Hu, Hao; Yoshida, Lay‐Myint

doi:10.1016/j.ijid.2018.08.001

Cited by 42 publications

(52 citation statements)

References 53 publications

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“…Kurskaya and Machablishvili [3,6] reported that the positive rate of in uenza increased with age, which is consistent with us. Kurskaya and Dong [3,9] also reported that the highest detection rate of in uenza was in winter, Althouse [17] reported that the peak of in uenza appeared in the middle of spring (April to June). Our results show that FLUA is the dominant factor in in uenza, while Luniewska [18] reported that FLUA and FLUB were both dominant in the epidemic season.…”

Section: Discussionmentioning

confidence: 95%

Epidemiological characteristics of four common respiratory viral infections in children

Zhu

Zhang

et al. 2020

Preprint

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Abstract Background: Viruses are the main infectious agents of ARIs in children. We aim to describe the epidemiological characteristics of viral pathogens of acute respiratory tract infections in outpatient children. Methods: From April 2018 to March 2019, the results of viral detection in oral pharyngeal swabs in 103 210 children with acute respiratory tract infection in the outpatient department of the Children’s Hospital, Zhejiang University School of Medicine were retrospectively analyzed. Viral antigens, including adenovirus (ADV), influenza A (FLUA), influenza B (FLUB) and respiratory syncytial virus (RSV) were detected by colloidal gold method. Results: At least one virus was detected in 38 355 cases, and the total positive rate was 37.2%. A total of 1910 cases of mixed infection with two or more viruses were detected, and the positive rate of multiple infection was 1.9%. ADV positive rate was the highest in 3-6-year-old group (18.7%), FLUA positive rate was the highest in >6-year-old group (21.6%), FLUB positive rate was the highest in >6-year-old group (6.6%) and RSV positive rate was the highest in <1-year-old group (10.6%). There was significant difference in the positive rate of viral infection among different age groups, χ2 = 1280.7, P < 0.001. The positive rate of viral infection was the highest in winter (47.1%). ADV infection rate was highest in spring (18.2%). The positive rates of FLUA and FLUB were the highest in winter (28.8% and 3.6%, respectively). The positive rate of RSV was the highest in autumn (17.4%). The positive rate of viral infection in different seasons had significant difference, χ2 = 6459.1, P < 0.001. Conclusions: Viral infection rates in children are different in different ages and seasons. ADV positive rate is the highest in preschool age, RSV positive rate is the highest in infants, and FLU positive rate increases with age. The total positive rate of viral infection in different seasons was the highest in winter. The positive rate of FLU was the highest in winter.

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Section: Discussionmentioning

confidence: 95%

Epidemiological characteristics of four common respiratory viral infections in children

Zhu

Zhang

et al. 2020

Preprint

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“…We found that the climate variable beside temperature, with the strongest correlation to RR and RoS was dew point, whereas precipitation, humidity and wind-speed did not appear to be significantly related to RR and RoS (Figure 4 and 5). Dew point temperature was previously shown to strongly associate with respiratory viruses spread rate and was recently found to explain approximately one third of the variation in transmission of enteroviruses across USA 22,23 . The dew point depends on both temperature and humidity and it is defined as the temperature to which air must be cooled at constant pressure for saturation to occur.…”

Section: Discussionmentioning

confidence: 98%

Climate effect on COVID-19 spread rate: an online surveillance tool

Caspi

Shalit

Kristensen

et al. 2020

Preprint

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Background: COVID-19 outbreak poses an unprecedented challenge for societies, healthcare organizations and economies. In the present analysis we coupled climate data with COVID-19 spread rates worldwide, and in a single country (USA). two measures: replication rate (RR), the slope of the logarithmic curve of confirmed cases, and the rate of spread (RoS), the slope of the linear regression of the logarithmic curve.Results: Based on predefined criteria, the mean COVID-19 RR was significantly lower in warm climate countries (0.12±0.02) compared with cold countries (0.24±0.01), (P<0.0001). Similarly, RoS was significantly lower in warm climate countries 0.12±0.02 vs. 0.25 ± 0.01 than in cold climate countries (P<0.001). In all countries (independent of climate classification) both RR and RoS displayed a moderate negative correlation with temperature R= -0.69, 95% confidence interval [CI], -0.87 to -0.36; P<0.001 and R= -0.72, 95% confidence interval [CI], -0.87 to -0.36; P<0.001, respectively. We identified a similar moderate negative correlation with the dew point temperature. Additional climate variables did not display a significant correlation with neither RR nor RoS. Finally, in an ancillary analysis, COVID-19 intra-country model using an inter-state analysis of the USA did not identify yet correlation between climate parameters and RR or RoS as of March, 19, 2020. Conclusions:Our analysis suggests a plausible negative correlation between warmer climate and COVID-19 spread rate as defined by RR and RoS worldwide. This initial correlation should be interpreted cautiously and be further validated over time, the pandemic is at different stages in various countries as well as in regions within these countries. As such, some associations may be more affected by local transmission patterns rather than by climate. Importantly, we provide an All rights reserved. No reuse allowed without permission.

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“…These findings might indicate that the timing of the catechin intake is also important for the virucidal activity in humans. Many virus infections, including influenza and the common cold, more commonly cause infection in the winter, in low-temperature seasons [32,33]. The circadian timings of infections, however, are unknown, and our understanding of the timing of infection during the day is limited [34,35].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial

et al. 2019

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Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61–1.92) in the low-catechin group and 0.46 (0.23–0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.

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Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam

Cited by 42 publications

References 53 publications

Epidemiological characteristics of four common respiratory viral infections in children

Epidemiological characteristics of four common respiratory viral infections in children

Climate effect on COVID-19 spread rate: an online surveillance tool

Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial

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