Seasonal Variation in Serum-25-Hydroxyvitamin-D in the Elderly in Britain

Lester, Eva P.; Skinner, R.K.; Wills, M. R.

doi:10.1016/s0140-6736(77)92280-2

Cited by 95 publications

(34 citation statements)

References 8 publications

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“…The mean level was similar to that of younger adults, in contrast to findings in Britain (19). Seasonal variations reported by other investigators (9,10,13,17,23,26) were not found in Jerusalem. This suggests that exposure to winter sunshine in Jerusalem is apparently sufficient for maintaining an adequate serum level of 25(OH)D3.…”

Section: Discussionsupporting

confidence: 82%

“…However, Hunt et al (12) who studied British Asians who kept a diary of the time spent outdoors found a significant correlation between 25(OH)D3 and outdoor time. Moreover, the high summer 25(OH)D3 among US lifeguards (9) whose exposure is particu larly high, and the decreased levels of submariners (22) after 2 months patrol service, despite a good diet, as well as the reported seasonal variations (9,10,13,17,23,26), emphasize the importance of sunlight. Our failure of finding an association between reported exposure to sunlight and serum 25(OH)D3 is possibly due to the fact that sunshine in Jerusalem is sufficient for preventing low serum levels of 25(OH)D3.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

et al. 1979

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Serum 25-hydroxycholecalciferol (25[OH]D₃) levels and other parameters of vitamin D nutriture were examined in 58 subjects aged 70 or more, living in Jerusalem. They were compared with those of 54 young adults living in the same neighbourhood. No evidence was obtained of a lower level of vitamin D nutriture in the elderly compared to younger adults. Serum 25(OH)D₃ of the elderly adults was 18.4 (SEM: 1.4) ng/ml and in the younger adults, 17.8 (1.0) ng/ml. There was no seasonal variation in serum 25(OH)D₃, nor could a strong association be found between reported vitamin D intake nor with exposure to sunshine. There was a negative correlation between serum alkaline phosphatase and the calcium-phosphorus product in serum. High values of alkaline phosphatase were associated with reported low exposure to sunlight and, in elderly persons, with a reported low consumption of vitamin D.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

et al. 1979

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“…3) supports our hypothesis. [17,[21][22][23], children [22], and elderly subjects [24], indicating an essential role of direct UV exposure in maintaining normal 25(OH)D levels. We also found seasonal variations in 25(OH)D concentrations in patients with Graves' disease; high levels were observed during summer and low levels were observed during winter (Fig.…”

Section: Laboratory Testsmentioning

confidence: 99%

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

et al. 2001

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Abstract.We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p <0.001) in female Graves' patients (31.8± 13.3 nmol/1) than in male patients (41.3 ± 15.0 nmol/1). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p<0.005).There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/1 found in 58% of female patients during the winter months. There were significant (p <0.001) differences in serum 25(OH)D levels between age groups in the female patients.The concentrations were lowest in patients in their twenties (25.1 ±8.2 nmol/1) and highest in patients in their fifties and sixties (43.2± 13.7 nmol/1). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.

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“…Chronically ill geriatric patients have low serum 25-hydroxyvitamin D (25-OH-D) concentrations which is lower than that of residents of old peoples' homes [1,2]. Lester et al [6] found low 25-OH-D in nonhousebound elderly people in the UK, whereas Guggenheim et al [4] did not observe any difference between a group of healthy elderly and young healthy adults in Israel with regard to the 25-OH-D concentration. They did not either see any seasonal variation in the 25-OH-D concentration neither in the elderly nor in the young adults in contrast with reports on seasonal variation in the 25-OH-D concentration in young adults from the UK [10].…”

mentioning

confidence: 99%

Vitamin D Intake, Sunlight Exposure and 25-Hydroxyvitamin D Levels in the Elderly during One Year

Lamberg‐Allardt¹

1984

Ann Nutr Metab

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3 groups of elderly people (65–80 years) were studied as regards their serum 25-hydroxyvitamin D (25-OH-D) concentrations, their dietary vitamin D intake and sunlight exposure during 1 year: group 1 (long-stay geriatric patients); group 2 (residents at an old people’s home), and group 3 (elderly people living in their own homes). Young adults (30–50 years) served as controls. The 25-OH-D concentration in group 1 was significantly lower during the whole year than in any other group and the concentration in group 2 was significantly lower than in group 3 and the controls. The low 25-OH-D level in the long-stay geriatric patients and in the residents at the old people’s home is a consequence of both a low dietary vitamin D intake and a low exposure to sunlight.

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Seasonal Variation in Serum-25-Hydroxyvitamin-D in the Elderly in Britain

Cited by 95 publications

References 8 publications

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

Biochemical Parameters of Vitamin D Nutriture in Old People in Jerusalem

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

Vitamin D Intake, Sunlight Exposure and 25-Hydroxyvitamin D Levels in the Elderly during One Year

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