Seasonal variation in estrogen receptor ERα, but not ERβ, androgen receptor and aromatase, in the efferent ductules and epididymis of the big fruit-eating bat Artibeus lituratus

Oliveira, Regiana L.; Nogueira, José Carlos; Mahecha, Germán Arturo Bohórquez; Oliveira, Cleida A.

doi:10.1016/j.ygcen.2012.06.028

Cited by 13 publications

(5 citation statements)

References 59 publications

(114 reference statements)

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“…Estrogens In addition to a testicular origin (Hess et al 2011), estrogen might also be produced locally in the epididymis, since aromatase was shown to be expressed in various epididymal structures (Hess et al 2011, Oliveira et al 2012.…”

Section: Regulation By Hormonesmentioning

confidence: 99%

“…Classical estrogen receptors (ESRs) were described in the epididymis of different species and primarily found in the epithelium (Hess et al 2011, Rago et al 2018), but also in SMCs (Oliveira et al 2012, Rago et al 2018). Regional differences of ESR1 expression are suggested to induce varying estrogen effects along the epididymis (Hess et al 2011).…”

Section: Regulation By Hormonesmentioning

confidence: 99%

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Contractility of the epididymal duct - function, regulation and potential drug effects

et al. 2018

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During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.

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Section: Regulation By Hormonesmentioning

confidence: 99%

Section: Regulation By Hormonesmentioning

confidence: 99%

Contractility of the epididymal duct - function, regulation and potential drug effects

et al. 2018

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“…Much evidence suggests the participation of oestrogens in regulating epididymal function. The source for oestrogen could be spermatozoa in the epididymal lumen and biosynthesis in the epididymal epithelium (Pereyra‐Martinez et al ., ; Carreau et al ., ; Carpino et al ., ; Shayu & Rao, ; Joseph et al ., ; Oliveira et al ., ). The classical oestrogen receptors, ESR1 and ESR2, and the G protein‐coupled oestrogen receptor, GPER, are present in the epididymis (rev.…”

Section: Introductionmentioning

confidence: 97%

“…in Hess et al ., ). Although the most dramatic effects of the knockout of ESR1 (Lubahn et al ., ; Eddy et al ., ; Hess et al ., ) and treatment with the anti‐oestrogen Fulvestrant (Oliveira et al ., , ; Cho et al ., ) are observed in the efferent ductules, which are considered the major target of oestrogen action in males, the epididymis also seems an important target for oestrogen (Hess et al ., ; Joseph et al ., ; Oliveira et al ., ). The knockout of ESR1 ( Esr1 −/− ) decreases luminal fluid osmolality, probably as a consequence of inappropriate fluid absorption (Joseph et al ., ,b), and increases pH throughout the epididymis, probably as a consequence of the reduced expression of enzymes and carriers involved in the acid/base control (Joseph et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium

et al. 2014

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SUMMARYThe role of oestrogens in epididymal function is still unclear. Knockout of the oestrogen receptor ESR1 (Esr1 À/À ) or treatment with the anti-oestrogen Fulvestrant affect epididymal milieu and sperm motility. We investigated the effect of in vivo treatment of rats with Fulvestrant on: (i) expression of genes that may be important for the architecture and function of the epididymal epithelium: prominins 1 and 2, metalloproteinase 7, claudin 7, beta-catenin and cadherin 13, and (ii) levels of oestradiol and testosterone, and expression of oestrogen and androgen receptors, in the initial segment (IS), caput, corpus and cauda epididymis. Fulvestrant (i) reduced gene expression of prominin 1 (variant 1) in the caput, reduced prominin 1 protein content in the caput epididymis and in the efferent ductules, and increased the localization of prominin 1 in microvilli of the caput and corpus; (ii) reduced gene expression of prominin 2 in the corpus and cauda epididymis; (iii) increased the metalloproteinase 7 content in the apical region of principal cells from IS/caput; (iv) reduced in the corpus epididymis, but increased in the efferent ductules, the cadherin 13 mRNA level; (v) reduced testosterone but increased oestradiol levels in the corpus and cauda; (vi) increased the androgen receptor protein content in all regions of the epididymis, and the oestrogen receptor GPER in the corpus and cauda epididymis. In conclusion, treatment with Fulvestrant induced regional-specific changes in hormonal and steroid receptor content, and affected expression of proteins important for epithelial organization and absorption/secretion. The mechanisms of oestrogen action may differ among epididymal regions, which may contribute to determine region-specific sperm functions.

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“…Reproductive cycle regarding seasons has been reported mostly in insectivorous bats [6,7,8] . Also, there are reports on neotropical fruit-eating bats, Artibeus lituratus and another micro chiropteran whose reproductive cycle varies regionally with seasonal factors [9,10,11,12] . However, there is little or no information on the seasonal changes in the reproductive cycle of adult male Epomops franqueti, a megachiropteran and pteropodid [13] , widely distributed in the West African region, including Nigeria [14] .…”

Section: Introductionmentioning

confidence: 99%

Reproductive cycle in the male African fruit bat (Epomops franqueti)

Kazeem¹,

Samuel²,

Bankole³

2022

J. Entomol. Zool. Stud.

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Epomops franqueti is common in Sub-Saharan Africa. Unlike micro chiropteran, information on the reproductive activity of this bat is scanty. The morpho-physiology of the testis and epididymis of E. franqueti was investigated to determine the seasonal reproductive activity. Sixty adult male E. franqueti were captured at the University of Ibadan, Nigeria. Histomorphometry of the testis and epididymis was investigated. Serum hormonal assays were carried out using ELISA. Concentrations of testosterone, FSH, and LH were least (0.25, 5.80, and 7.01 IU/L, respectively) and highest (3.80, 12.03 and 14.04 IU/L, respectively) during late dry and late wet seasons, respectively, being significantly different. The early and late wet seasons had the highest gonadosomatic (0.20%) and epididymal mass (0.08%) indices, respectively. The least values were recorded during the early dry season for both gonadosomatic (0.15%) and epididymal mass (0.06%) indices. Epomops franqueti may be a seasonal breeder.

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Seasonal variation in estrogen receptor ERα, but not ERβ, androgen receptor and aromatase, in the efferent ductules and epididymis of the big fruit-eating bat Artibeus lituratus

Cited by 13 publications

References 59 publications

Contractility of the epididymal duct - function, regulation and potential drug effects

Contractility of the epididymal duct - function, regulation and potential drug effects

Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium

Reproductive cycle in the male African fruit bat (Epomops franqueti)

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