Seasonal influences on admissions in schizophrenia and affective disorder in Ireland

Clarke, Mary; Moran, P.; Keogh, Fiona; Morris, Mary; Kinsella, Anthony; Walsh, Dermot; Larkin, Conall; O’Callaghan, Eadbhard

doi:10.1016/s0920-9964(98)00106-6

Cited by 21 publications

(25 citation statements)

References 17 publications

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“…It has been suggested that periods of reduced admissions should be studied in order to understand the role of protective factors in preventing or delaying admissions (Clarke et al, 1998;Eagles, 1995); the findings of the present study support this approach. Previously suggested protective factors include the supportive role of the family (Falloon et al, 1984) and participation in holiday rituals (Luboshitzky & Gaber, 2001), both of which are supported by the present findings of reduced admissions during the Passover holiday period.…”

Section: Discussionsupporting

confidence: 69%

The Role of Environmental Influences on Schizophrenia Admissions in Israel

Aviv

Bromberg

Baruch

et al. 2011

International Journal of Social Psychiatry

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This study demonstrated significant monthly variability in admission rates and a possible protective effect of a widely celebrated public religious holiday. A consistent effect of season upon rates of admission was not found. Future studies need to identify which specific social factors exert a protective or harmful effect and study how knowledge of these effects can be translated into clinical practice.

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Section: Discussionsupporting

confidence: 69%

The Role of Environmental Influences on Schizophrenia Admissions in Israel

Aviv

Bromberg

Baruch

et al. 2011

International Journal of Social Psychiatry

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“…Several studies have reported seasonal variations in admissions for people diagnosed with psychosis and schizophrenia (Clarke et al . , Daniels et al . , De Graaf et al .…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, an interesting seasonal effect was observed. Several studies have reported seasonal variations in admissions for people diagnosed with psychosis and schizophrenia (Clarke et al 1998, Daniels et al 2000, De Graaf et al 2005, Cheng et al 2008. These studies drawn from several countries have produced inconsistent findings with some observing a winter peak for admissions and others a summer peak.…”

Section: Discussionmentioning

confidence: 99%

The impact of assertive outreach teams on hospital admissions for psychosis: a time series analysis

Hamilton

Lloyd

Bland

et al. 2015

Psychiatric Ment Health Nurs

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Although the assertive outreach model was developed in the United States and imported to the United Kingdom to date, there is only limited evidence to support its wide-scale implementation within the United Kingdom. This is the first study to have combined a large dataset with this type of research method to explore the impact of assertive outreach teams on hospital admissions. The introduction and expansion of assertive outreach teams was associated with reducing hospital admissions for people with psychosis. This study found a consistent summer peak in hospital admissions which community and in-patient mental health nurses should take account of and plan for. Ever since the Mental Health Policy Implementation Policy Guide paved the way for the introduction of the Assertive Outreach Treatment (AOT) model in England, the impact of this approach has been the subject of considerable debate but limited evaluation. To date, most of the evidence supporting this model has originated from outside the United Kingdom. A central aim of the AOT was to reduce the need for in-patient treatment. We aimed to assess the impact of the AOT model on hospital admissions for people with psychosis in England. Interrupted time series analysis was used in this study to evaluate the impact of the policy change. Following the introduction of the AOT model, a statistically significant reduction in hospital admissions for psychosis was found. In addition, we observed a repeated, annual summer peak in admissions. This study adds to the international evidence which supports the effectiveness of the AOT model in reducing hospital admissions for people with severe mental health problems. We offer five suggested implications for mental health nurses and clients based on our findings.

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“…In England and Wales, for example, Hare and Walter (1978) 51 found a summer peak of schizophrenia admissions. Clarke et al (1998) 53 found a seasonal association in first episode schizophrenia admissions in Ireland, although this association varied on an annual basis. In a subsequent study, Clarke et al (1999) 54 found that the seasonal association only held for first admissions and not for subsequent admissions.…”

Section: Discussionmentioning

confidence: 99%

Seasonality Shows Evidence for Polygenic Architecture and Genetic Correlation With Schizophrenia and Bipolar Disorder

Byrne

Raheja

Stephens³

et al. 2014

J. Clin. Psychiatry

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Objective To test common genetic variants for association with seasonality (seasonal changes in mood and behavior) and to investigate whether there are shared genetic risk factors between psychiatric disorders and seasonality. Methods A meta-analysis of genome-wide association studies (GWAS) conducted in Australian and Amish populations in whom the Seasonal Pattern Assessment Questionnaire (SPAQ) had been administered. The total sample size was 4,156 individuals. Genetic risk scores based on results from prior large GWAS studies of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ) were calculated to test for overlap in risk between psychiatric disorders and seasonality. Results The most significant association was with rs11825064 (p = 1.7 × 10−6, β = 0.64, S.E = 0.13), an intergenic SNP found on chromosome 11. The evidence for overlap in risk factors was strongest for SCZ and seasonality, with the SCZ genetic profile scores explaining 3% of the variance in log-transformed GSS. BD genetic profile scores were also significantly associated with seasonality, although at much weaker levels, and no evidence for overlap in risk was detected between MDD and seasonality. Conclusions Common SNPs of very large effect likely do not exist for seasonality in the populations examined. As expected, there was overlapping genetic risk factors for BD (but not MDD) with seasonality. Unexpectedly, the risk for SCZ and seasonality had the largest overlap, an unprecedented finding that requires replication in other populations, and has potential clinical implications considering overlapping cognitive deficits in seasonal affective disorders and SCZ

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Seasonal influences on admissions in schizophrenia and affective disorder in Ireland

Cited by 21 publications

References 17 publications

The Role of Environmental Influences on Schizophrenia Admissions in Israel

The Role of Environmental Influences on Schizophrenia Admissions in Israel

The impact of assertive outreach teams on hospital admissions for psychosis: a time series analysis

Seasonality Shows Evidence for Polygenic Architecture and Genetic Correlation With Schizophrenia and Bipolar Disorder

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