Searching for an effective, safe and universal anti-HIV vaccine: Finding the answer in just one short peptide

Selfness-nonselfness in designing an anti-B19 erythrovirus vaccine

“…The B19 erythrovirus-versus-human pentapeptide profile is illustrated in Figure 1. It is evident that, in agreement with results obtained from previous analyses on various viruses, [29][30][31][32][33][34][35][36][37][38] the B19 erythrovirus polyprotein sequence presents both portions only rarely or not at all represented in the human proteome and regions with a high similarity to human proteins. In a few cases, the level of similarity is reflected in hundreds or thousands of exact pentapeptide matches.…”

“…The A pentapeptide similarity analysis of the B19 viral proteins was conducted against the human proteome as described under Methods (see also refs. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. Briefly, the number of matches scores the similarity level to the human proteome for each pentapeptide, and is obtained using pIR perfect peptide Match program (http://pir.georgetown.edu).…”

A quantitative description of the peptide sharing between poliovirus andHomo sapiens

“…On the whole, the polio-versushuman peptide overlap repeats a fractal distributional pattern already seen in Influenza A H5N1 (25) and other viruses. (20)(21)(22)(23)(24)(26)(27)(28) Polio peptide overlap on the human proteome may affect host cellular functions Analysis of the viral-versus-human overlap at the octapeptide level indicates that the viral motifs are present in human proteins exerting fundamental biological functions ( Table 2). (32)(33)(34)(35)(36)(37)(38) For example, Table 2 shows that serine/threonine-protein kinase SMG1 (or Suppressor of Morphogenesis in Genitalia-1; UniProtKB/Swiss-Prot accession number: Q96Q15), (39) hosts the polio P2C 131-138 PGTGKSVA peptide.…”

“…(16)(17)(18)(19) Given these basic assumptions, our research rationale is that defining the peptide similarities that occur between infectious viruses and humans may provide insights into the molecular basis of viral pathogenesis, and open possible peptide-based therapeutical avenues to prevent or cure viral infections. (14,15) In this study, we continue our studies essentially directed toward a mathematical definition of the similarity levels between viruses and humans, (20)(21)(22)(23)(24)(25)(26)(27)(28) and analyze the peptide commonality linking poliovirus and the human host. We report that poliovirus is no exception to the rule of a massive and indiscriminate peptide research artIcle A quantitative description of the peptide sharing between poliovirus and Homo sapiens overlapping between viral and human proteomes, (12) and discuss the possibility of a functional role(s) of peptide overlap in the virus-host relationship(s).…”

A peptide talk between JC virus and the human host: from silent infection to autoimmunity

“…More in general, this study synthesizes a methodological approach that might guarantee exemption from collateral adverse cross-reactions and render practicable antimicrobial global vaccination campaigns. (58,82,(86)(87)(88) …”