Search for Drugs Used in Hospitals to Treat Stomatitis

Abstract

Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Chemotherapy, especially in the head and neck region, induces stomatitis at higher frequency, which directly affects the patient’s quality of life and treatment schedule. However, effective treatment for stomatitis has yet to be established. This article presents the clinical report of Kampo medicines on the stomatitis patients in the Nihon university, and then reviews the literature of traditional medicines for the treatment of stomatitis. Among eighteen Kampo medicines, Hangeshashinto has been the most popular for the treatment of stomatitis, due to its prominent anti-inflammatory activity. It was unexpected that clinical data of Hangeshashinto on stomatitis from Chinese hospital are not available. Kampo medicines have been most exclusively administered to elder person, as compared to pediatric population. Supplementation of alkaline plant extracts rich in lignin-carbohydrate complex may further extend the applicability of Kampo medicines to viral diseases.

Introduction to the Special Issue “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”

“…Hara et al showed that among 18 Kampo medicines, HST is most frequently used in Japan, possibly due to the presence of glycyrrhiza that contains anti-inflammatory glycyrrhizin. It was surprising that HST had not been used in China [5]. Traditional medicines have been prescribed to elders and adults rather than children, but inclusion of sweet licorice as an ingredient will make it easier for children to take [5].…”

“…It was surprising that HST had not been used in China [5]. Traditional medicines have been prescribed to elders and adults rather than children, but inclusion of sweet licorice as an ingredient will make it easier for children to take [5].…”

“…This Special Issue picks up 11 articles, that are listed in four separate sections: Section 1 (Antiviral and antibacterial agents [1,2]); Section 2 (Kampo medicine and constitutive plant extracts [3,4,5,6]); Section 3 (Protection mechanism, [7,8]; (Application of metabolomics and quantitative structure-activity relationship (QSAR) [9,10,11]).…”

Effect of Glycyrrhizin and Sappan Wood Extract on Chemically- Induced Oral Mucosal Ulcer: An in vivo Animal Study

“…However, frequent and long-term exposure to these drugs may further lead to more adverse effects and often drug resistance. 6,7 Natural medicines have become increasingly used in many countries. These become popular among consumers who search for natural ways as an alternative therapy and the general feeling that natural medicines are safer than synthetic drugs.…”

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

“…Oral mucositis is one of the most common complications during chemotherapy and some local radiotherapies that can give significant effect on continuation of the therapy. Oral mucositis results in erythema and ulceration of the non-keratinized mucosa, causing suffering pain, decrease in nutritional intake, and bloodstream infections [ 1 , 2 , 3 ]. In general, the etiology of chemotherapy-induced mucositis can be divided into two main causes.…”