Scutellaria barbata D.Don and Oldenlandia diffusa (Willd.) Roxb crude extracts inhibit hepatitis-B-virus-associated hepatocellular carcinoma growth through regulating circRNA expression

Yang, Peiwei; Chen, Tingting; Zhao, Wenxia; Liu, Guangwei; Feng, Xiaohai; Wang, Shou‐Mei; Pan, Yun-Cui; Wang, Qian; Zhang, Shu‐Hui

doi:10.1016/j.jep.2021.114110

Cited by 20 publications

(13 citation statements)

References 20 publications

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“…For example, Yang et al reported that Scutellaria barbata D. Don (SB) and Oldenlandia diffusa (Willd.) Roxb may inhibit hepatocellular carcinoma cell growth in vitro and in vivo through altering circRNA-miRNA-gene expression [ 13 ]. In addition, Xu et al showed that curcumin, discovered in Curcuma longa , inhibited NSCLC growth through downregulating circ-PRKCA [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145

Shen

2022

Evidence-Based Complementary and Alternative Medicine

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Circular RNA (circRNA) is considered an important regulator of cancer. Circ_0001998 is a newly discovered circRNA and its role in lung adenocarcinoma (LUAD) remains obscure and requires further study. The expression levels of circ_0001998 and miR-145 in LUAD were predicted by bioinformatics analysis and then verified by qRT-PCR in the LUAD cell lines. CCK-8, clone formation, EdU assay, and flow cytometry were applied to determine the effects of silencing circ_0001998 on the viability, proliferation, and apoptosis of LUAD cells. The target relationship between circ_0001998 and miR-145 was predicted by bioinformatics analysis and verified by a luciferase activity experiment. The effect of circ_0001998/miR-145 axis on the viability, proliferation, and apoptosis of LUAD cells was verified by the rescue experiment. Circ_0001998 was upregulated in LUAD, and silencing circ_0001998 suppressed viability, proliferation, and invasion of LUAD cells. The target gene of circ_0001998, miR-145, was downregulated in LUAD, and the low expression of miR-145 indicated a poor prognosis. The effect of silencing circ_0001998 on the biological function of LUAD cells was reversed by the miR-145 inhibitor. Circ_0001998 regulates the proliferation, invasion, and apoptosis of LUAD via sponging miR-145.

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Section: Discussionmentioning

confidence: 99%

Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145

Shen

2022

Evidence-Based Complementary and Alternative Medicine

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“…FLOT1 is highly expressed in a variety of tumor cells, but the down-regulation of FLOT1 by luteolin directly inhibits the growth of hepatoma cells. In most biological processes of liver cancer, multiple signaling pathways, including ERK1/2, p38, JNK, and NF-ΚB/P65, are overexpressed by miR-6809-5p or downregulated and inactivated by Flot1 85 . However, in the luteolin study, extracts from Scutellaria baicalensis Georgi and Hedyotis diffusa were found to inhibit HCC cell growth and Hepatitis B virus activity in vivo and in vivo by altering circRNA-miRNA gene expression, the efficacy of these extracts may be consistent with that of Luteolin in the presence of apigenin 86 .…”

Section: Mechanism and Clinical Application Of Luteolin In The Treatm...mentioning

confidence: 99%

“…In most biological processes of liver cancer, multiple signaling pathways, including ERK1/2, p38, JNK, and NF-ΚB/P65, are overexpressed by miR-6809-5p or downregulated and inactivated by Flot1 85 . However, in the luteolin study, extracts from Scutellaria baicalensis Georgi and Hedyotis diffusa were found to inhibit HCC cell growth and Hepatitis B virus activity in vivo and in vivo by altering circRNA-miRNA gene expression, the efficacy of these extracts may be consistent with that of Luteolin in the presence of apigenin 86 . Based on network pharmacology and molecular docking techniques, Liu et al 87 found that luteolin, as the main component of Polygonum hydropiper, was successfully combined with AKT1 to treat liver cancer, and the therapeutic effect of luteolin was verified by experiments, the levels of P-AKT mirnas are reduced in low-grade liver cancer cells and have regulatory effects on various genes such as AKT1, JUN, MAPK1, RELA, IL6, and MAPK14.…”

Section: Mechanism and Clinical Application Of Luteolin In The Treatm...mentioning

confidence: 99%

Advances in the Mechanism of Luteolin against Hepatocellular Carcinoma Based on Bioinformatics and Network Pharmacology

Han¹,

Xiao²,

Lei³

et al. 2023

J. Cancer

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As one of the most common malignant tumors, hepatocellular carcinoma (HCC) has a rising incidence rate and also seriously endangers human life and health. According to research reports, hepatitis B, hepatitis C, intake of aflatoxin in the diet, and the effects of alcohol and other chemicals can induce an increase in the incidence of liver cancer. However, in the current clinical treatment of HCC, most of the drugs are chemical drugs, which have relatively large side effects and are prone to drug resistance. Therefore, the development of natural compounds to treat HCC has become a new treatment strategy. Several studies have shown that flavonoids have shown outstanding effects and exhibit strong tumor growth inhibitory effects in vivo experimental studies. Luteolin, as a natural flavonoid, has anti-tumor, anti-inflammatory, anti-viral, anti-oxidation, immune regulation, and other pharmacological effects. The anti-cancer mechanism of luteolin mainly directly acts on tumor cells to inhibit their growth, induce cell apoptosis, reduce tumor tissue angiogenesis, regulate long non-coding RNA, affect immunogenic cell death, and regulate autophagy. As well as improving the curative effect of radiotherapy and chemotherapy and chemoprevention. In this study, we evaluated the function of luteolin in regulating cancer cell proliferation, migration, and invasion will summarize and analyze luteolin and its mechanism of regulating HCC to improve the role of luteolin in the clinical prevention and treatment of HCC.

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“…Although FOD can inhibit the proliferation and induce apoptosis of HCC cells ( Huang et al, 2021 ) ( Yang et al, 2021 ), the mechanism underlying its cytotoxicity to HCC cells and the role of reticulum (ER) stress remain unclear. Therefore, we investigated whether HDW induces autophagy and apoptosis through ER stress-signalling pathways in HCC cells.…”

Section: Introductionmentioning

confidence: 99%

Total flavonoids of Oldenlandia diffusa (Willd.) Roxb. suppresses the growth of hepatocellular carcinoma through endoplasmic reticulum stress-mediated autophagy and apoptosis

et al. 2022

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Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors in the world. Although the current treatment methods for HCC are gradually increasing, its efficacy still cannot meet the medical needs of patients with liver cancer, and new and effective treatment strategies are urgently needed. The total flavonoids of Oldenlandia diffusa (FOD) are the main active components in Oldenlandia diffusa, which have anti-inflammatory, antioxidant and anti-tumor effects, but their mechanism of action in liver cancer is unclear. In this study, we examined the effect of FOD on HCC. Using both in vitro and in vivo models, we confirmed that FOD inhibited HCC proliferation and induced apoptosis and autophagy. Mechanistic studies have shown that FOD induces apoptosis and activates autophagy in HCC cells by inducing endoplasmic reticulum stress (ER stress) and activating the PERK-eIF2α-ATF4 signaling pathway. Taken together, our results suggest that FOD is a potential anticancer drug targeting ER stress for the treatment of HCC.

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Scutellaria barbata D.Don and Oldenlandia diffusa (Willd.) Roxb crude extracts inhibit hepatitis-B-virus-associated hepatocellular carcinoma growth through regulating circRNA expression

Cited by 20 publications

References 20 publications

Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145

Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145

Advances in the Mechanism of Luteolin against Hepatocellular Carcinoma Based on Bioinformatics and Network Pharmacology

Total flavonoids of Oldenlandia diffusa (Willd.) Roxb. suppresses the growth of hepatocellular carcinoma through endoplasmic reticulum stress-mediated autophagy and apoptosis

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