Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination

Li, Yuanzhi; Wang, Jundong; Zhong, Sen; Li, Jun; Du, Wei

doi:10.3892/ijmm.2020.4496

Cited by 13 publications

(11 citation statements)

References 48 publications

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“…As shown in many studies mentioned in this review investigating the role of RAGE by its blockage through siRNA and antibodies and antagonists treatment, RAGE activation stopped, as well as underlying mechanisms leading to tumorigenicity. Also, it has been indicated that antibodies against RAGE ligands can decrease the risk of CRC (178)(179)(180)(181)(182). This, as mentioned before, the effect of prolonged RAGE blockade in human subjects is important because RAGE plays vital roles in normal physiology.…”

Section: Therapeutic Strategies Against Rage In Crcmentioning

confidence: 81%

Receptor for Advanced Glycation End Products Acts as a Fuel to Colorectal Cancer Development

et al. 2020

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Receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-pass transmembrane protein taken in diverse chronic inflammatory conditions. RAGE behaves as a pattern recognition receptor, which binds and is engaged in the cellular response to a variety of damage-associated molecular pattern molecules, as well as HMGB1, S100 proteins, and AGEs (advanced glycation end-products). The RAGE activation turns out to a formation of numerous intracellular signaling mechanisms, resulting in the progression and prolongation of colorectal carcinoma (CRC). The RAGE expression correlates well with the survival of colon cancer cells. RAGE is involved in the tumorigenesis, which increases and develops well in the stressed tumor microenvironment. In this review, we summarized downstream signaling cascade activated by the multiligand activation of RAGE, as well as RAGE ligands and their sources, clinical studies, and tumor markers related to RAGE particularly in the inflammatory tumor microenvironment in CRC. Furthermore, the role of RAGE signaling pathway in CRC patients with diabetic mellitus is investigated. RAGE has been reported to drive assorted signaling pathways, including activator protein 1, nuclear factor-κB, signal transducer and activator of transcription 3, SMAD family member 4 (Smad4), mitogen-activated protein kinases, mammalian target of rapamycin, phosphoinositide 3-kinases, reticular activating system, Wnt/β-catenin pathway, and Glycogen synthase kinase 3β, and even microRNAs.

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Section: Therapeutic Strategies Against Rage In Crcmentioning

confidence: 81%

Receptor for Advanced Glycation End Products Acts as a Fuel to Colorectal Cancer Development

et al. 2020

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“…Also, Gu et al found that quercetin may be a promising therapeutic avenue for SARS-CoV-2 injury-induced AKI [ 39 ]. Scutellarein is a flavonoid monomer that has been demonstrated to exert various pharmacological effects including anticancer [ 40 ], anti-inflammatory [ 41 ], and antifibrosis activities [ 42 ]. Furthermore, a recent study found that diosmetin also has renoprotective effects in the sepsis-induced AKI model by activating the TUG1/Nrf2/HO-1 pathway [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways

Chen

et al. 2021

BioMed Research International

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Acute kidney injury (AKI) is responsible for significant mortality among hospitalized patients that is especially troubling aged people. An effective self-made Chinese medicine formula, Xiaoyu Xiezhuo Drink (XXD), displayed therapeutic effects on AKI. However, the compositions and underlying mechanisms of XXD remain to be elucidated. In this study, we used the ultra-high-performance liquid chromatography method coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) to investigate the chemical components in XXD. Then, the absorbable components of XXD were identified based on the five principles and inputted into the SwissTargetPrediction and STITCH databases to identify the drug targets. AKI-related targets were collected from the GenCLiP 3, GeneCards, and DisGeNET databases. The crossover genes of XXD and AKI were identified for functional enrichment analysis. The protein-protein interaction (PPI) network of crossover genes was constructed, followed by the identification of hub genes. Subsequently, the effects and potential mechanisms of XXD on AKI predicted by the network pharmacology and bioinformatics analyses were experimentally validated in ischemia-reperfusion (I/R) injury-induced AKI aged mouse models. A total of 122 components in XXD were obtained; among them, 58 components were found that could be absorbed in the blood. There were 800 potential drug targets predicted from the 58 absorbable components in AKI which shared 36 crossover genes with AKI-related targets. The results of functional enrichment analysis indicated that crossover genes mostly associated with the response to oxidative stress and the HIF1 signaling pathway. In the PPI network analysis, 12 hub genes were identified, including ALB, IL-6, TNF, TP53, VEGFA, PTGS2, TLR4, NOS3, EGFR, PPARG, HIF1A, and HMOX1. In AKI aged mice, XXD prominently alleviated I/R injury-induced renal dysfunction, abnormal renal pathological changes, and cellular senescence, inflammation, and oxidative damage with a reduction in the expression level of the inflammatory mediator, α-SMA, collagen-1, F4/80, TP53, VEGFA, PTGS2, TLR4, NOS3, EGFR, PPARG, HIF1A, ICAM-1, TGF-β1, Smad3, and p-Smad3 and an increase of nephridial tissue p-H3, Ki67, HMOX1, MMP-9, and Smad7 levels. In summary, our findings suggest that XXD has renoprotective effects against AKI in aged mice via inhibiting the TGF-β1/Smad3 and HIF1 signaling pathways.

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“…It can exert anti-inflammatory, anti-oxidant, and anti-cancer effects ( Kang et al, 2020 ). Scutellarein is a flavone present in huangqin which can exert a higher bioavailability compared with scutellarin ( Li et al, 2020c ). Helicase protein is also served as a potential target for the development of anti-HCoV (human coronavirus) preparations.…”

Section: The Anti-novel Coronaviral Compound From Tcm—anti-inflammatory Responsesmentioning

confidence: 99%

The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19

Cheng

Yao

et al. 2021

Front. Pharmacol.

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Inflammasomes are large multimolecular complexes best recognized because of their ability to control activation of caspase-1, which in turn regulates the maturation of interleukin-18 (IL-18) and interleukin-1 β (IL-1β). IL-1β was originally identified as a pro-inflammatory cytokine, capable of inducing local and systemic inflammation as well as a fever response reaction in response to infection or injury. Excessive production of IL-1β is related to inflammatory and autoimmune diseases. Both coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS) are characterized by excessive inflammatory response. For SARS, there is no correlation between viral load and worsening symptoms. However, there is no specific medicine which is available to treat the disease. As an important part of medical practice, TCM showed an obvious therapeutic effect in SARS-CoV-infected patients. In this article, we summarize the current applications of TCM in the treatment of COVID-19 patients. Herein, we also offer an insight into the underlying mechanisms of the therapeutic effects of TCM, as well as introduce new naturally occurring compounds with anti-coronavirus activity, in order to provide a new and potential drug development strategy for the treatment of COVID-19.

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Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination

Cited by 13 publications

References 48 publications

Receptor for Advanced Glycation End Products Acts as a Fuel to Colorectal Cancer Development

Receptor for Advanced Glycation End Products Acts as a Fuel to Colorectal Cancer Development

Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-β1/Smad3 and HIF1 Signaling Pathways

The Therapeutic Effect of Traditional Chinese Medicine on Inflammatory Diseases Caused by Virus, Especially on Those Caused by COVID-19

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