Screening of the food additive propionic acid for genotoxic properties

Biological Monitoring of Exposure to Cisplatin in Rats Using SOS Chromotest

“…However, the result were assumed to be negative because the high levels of the induction factor did not ascribe to the increased activity of the b -Gal but to the decrease in the AP activity. Similar example can be seen in the case of propionic acid, which was proven to be nongenotoxi c in an extended test battery by Basler, von der Hude, and Scheutwinkel (1987). At high concentration of propionic acid, the activity of the b -Gal, an indicator of genotoxicity, had not increased.…”

Biological Monitoring of Exposure to Cisplatin in Rats Using SOS Chromotest

“…However, the result were assumed to be negative because the high levels of the induction factor did not ascribe to the increased activity of the b -Gal but to the decrease in the AP activity. Similar example can be seen in the case of propionic acid, which was proven to be nongenotoxi c in an extended test battery by Basler, von der Hude, and Scheutwinkel (1987). At high concentration of propionic acid, the activity of the b -Gal, an indicator of genotoxicity, had not increased.…”

Effects of Propionic Acid and Pravastatin on HMG‐CoA Reductase Activity in Relation to Forestomach Lesions in the Rat

“…unpublished data). According to a study of genotoxicity (Basler et al 1987) propionic acid cannot be regarded as carcinogenic.…”

Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives

“…Both sodium and calcium propionate were negative in the reversion mutation assay. Basler et al (1987) , in the SOS-chromotest using the Escherichia coli PQ37 tester strain, in the Salmonella/microsome test with Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100 both in the absence and presence of rat liver S9 metabolism (Arochlor-induced). All assays performed were exhaustively conducted with dose-levels adequately selected.…”

“…In the study by Basler et al (1987) propionic acid was assayed in the bone marrow micronucleus assay in male and female Chinese hamsters at the maximum tolerated dose of 124 mg/kg bw administered intraperitoneally as a single dose (2.5 % solution of propionic acid). Animals were sacrificed at 12, 24, or 48 hours after dosing and bone marrow collected and evaluated for the presence of micronucleated immature (polychromatic) erythrocytes.…”

“…In the study by Basler et al (1987), propionic acid was investigated for its genotoxicity in a sister chromatid exchange (SCE) assay both in the absence and presence of rat liver S9 metabolism in a Chinese hamster V79 cell line. The study included two independent experiments which were exhaustively conducted with dose-levels adequately selected.…”

Biological Monitoring of Exposure to Cisplatin in Rats Using SOS Chromotest

“…However, the result were assumed to be negative because the high levels of the induction factor did not ascribe to the increased activity of the b -Gal but to the decrease in the AP activity. Similar example can be seen in the case of propionic acid, which was proven to be nongenotoxi c in an extended test battery by Basler, von der Hude, and Scheutwinkel (1987). At high concentration of propionic acid, the activity of the b -Gal, an indicator of genotoxicity, had not increased.…”

Effects of Propionic Acid and Pravastatin on HMG‐CoA Reductase Activity in Relation to Forestomach Lesions in the Rat

“…unpublished data). According to a study of genotoxicity (Basler et al 1987) propionic acid cannot be regarded as carcinogenic.…”

Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives

“…Both sodium and calcium propionate were negative in the reversion mutation assay. Basler et al (1987) , in the SOS-chromotest using the Escherichia coli PQ37 tester strain, in the Salmonella/microsome test with Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100 both in the absence and presence of rat liver S9 metabolism (Arochlor-induced). All assays performed were exhaustively conducted with dose-levels adequately selected.…”

“…In the study by Basler et al (1987) propionic acid was assayed in the bone marrow micronucleus assay in male and female Chinese hamsters at the maximum tolerated dose of 124 mg/kg bw administered intraperitoneally as a single dose (2.5 % solution of propionic acid). Animals were sacrificed at 12, 24, or 48 hours after dosing and bone marrow collected and evaluated for the presence of micronucleated immature (polychromatic) erythrocytes.…”

“…In the study by Basler et al (1987), propionic acid was investigated for its genotoxicity in a sister chromatid exchange (SCE) assay both in the absence and presence of rat liver S9 metabolism in a Chinese hamster V79 cell line. The study included two independent experiments which were exhaustively conducted with dose-levels adequately selected.…”

Biological Monitoring of Exposure to Cisplatin in Rats Using SOS Chromotest

“…However, the result were assumed to be negative because the high levels of the induction factor did not ascribe to the increased activity of the b -Gal but to the decrease in the AP activity. Similar example can be seen in the case of propionic acid, which was proven to be nongenotoxi c in an extended test battery by Basler, von der Hude, and Scheutwinkel (1987). At high concentration of propionic acid, the activity of the b -Gal, an indicator of genotoxicity, had not increased.…”

Effects of Propionic Acid and Pravastatin on HMG‐CoA Reductase Activity in Relation to Forestomach Lesions in the Rat

“…unpublished data). According to a study of genotoxicity (Basler et al 1987) propionic acid cannot be regarded as carcinogenic.…”

Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives

“…Both sodium and calcium propionate were negative in the reversion mutation assay. Basler et al (1987) , in the SOS-chromotest using the Escherichia coli PQ37 tester strain, in the Salmonella/microsome test with Salmonella typhimurium tester strains TA1535, TA1537, TA98 and TA100 both in the absence and presence of rat liver S9 metabolism (Arochlor-induced). All assays performed were exhaustively conducted with dose-levels adequately selected.…”

“…In the study by Basler et al (1987) propionic acid was assayed in the bone marrow micronucleus assay in male and female Chinese hamsters at the maximum tolerated dose of 124 mg/kg bw administered intraperitoneally as a single dose (2.5 % solution of propionic acid). Animals were sacrificed at 12, 24, or 48 hours after dosing and bone marrow collected and evaluated for the presence of micronucleated immature (polychromatic) erythrocytes.…”

“…In the study by Basler et al (1987), propionic acid was investigated for its genotoxicity in a sister chromatid exchange (SCE) assay both in the absence and presence of rat liver S9 metabolism in a Chinese hamster V79 cell line. The study included two independent experiments which were exhaustively conducted with dose-levels adequately selected.…”