Screening of the adult population in Iran for coeliac disease: comparison of the tissue-transglutaminase antibody and anti-endomysial antibody tests

Abstract

The minimum prevalence of gluten sensitivity among the general population of northern and southern Iran is 1:104. The best screening test for the detection of GSE in the general population is IgA tTG-Ab.

Celiac disease in the Red Sea state of Sudan

“…22 The diagnosis of CD was confirmed by serological detection of the AGA and ATTGA. Tissue transglutamase IgA sensitivity is 70%-100%, 23,24 and its specificity is 99%. 24 The sensitivity of IgA AGA is about 80%, while that of IgG AGA is 90-100%.…”

“…Tissue transglutamase IgA sensitivity is 70%-100%, 23,24 and its specificity is 99%. 24 The sensitivity of IgA AGA is about 80%, while that of IgG AGA is 90-100%. 25,26 Endoscopic intestinal biopsy was not available in the region.…”

The Prevalence of Celiac Disease in Patients With Iron-Deficiency Anemia in Center and South Area of Iran

“…Screening studies show a high prevalence of CD (between 1/130-1/300) among both healthy children and adult populations in European countries (10,31) . In a recent study, the prevalence of CD in 2000 healthy blood donors was found to be 1.3% (1/166-1/104) in Iran (2,42) . Considering the wide range of clinical characteristics of CD, like anemia, osteoporosis, dermatitis herpetiformis, and neurologic problems and critical problems like non-Hodgkin's lymphoma, small bowel adenocarcinoma, esophageal cancer, and melanoma, early analysis of CD is crucial, because it is otherwise related to increased mortality (26,40,43) .…”

Celiac Disease Prevalence in the Patients with Irritable Bowel Syndrome in the Ilam Province; A Cross Sectional Study from Western Iran

“…Anti-gliadin anti body has low sensitivity and high false positive results of this test is common. Thus the test hasn't any application for the screening and the primary diagnose of CD [27]. Based on the conducted researches, serologic tests (antiendomysium antibody and tissue Trans glutamines antibody have high sensitivity and specificity.…”

“…Based on the conducted researches, serologic tests (antiendomysium antibody and tissue Trans glutamines antibody have high sensitivity and specificity. Also, the existence of this antibody is related to the degree of atrophy of villis [27,28]. In a study that was done in the khoozestan, the prevalence of IgA anti-TTG was reported about 1% in the population [29].…”