Screening of preservatives by HPLC-PDA-ESI/MS: A focus on both allowed and recently forbidden compounds in the new EU cosmetics regulation

Lecce, Raffaele; Regazzoni, Luca; Mustazza, Carlo; Incarnato, Giampaolo; Porrà, R; Panusa, Alessia

doi:10.1016/j.jpba.2016.03.044

Cited by 17 publications

(3 citation statements)

References 16 publications

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“…Oleh karena itu, penetapan kadar asam salisilat di dalam sediaan kosmetika sangat penting untuk memastikan kualitas produk kosmetika dan keselamatan konsumen. Banyak metode yang sudah dikembangkan dalam penetapan kadar asam salisilat di dalam sediaan kosmetika seperti kromatografi kapilar 3 , kromatografi cair kinerja tinggi 4 , kromatografi ion -ekslusi 5 , kapilari elektroforesis 6 dan spektrofotometri 7 . Spektrofotometri UV -Vis dipertimbangkan sebagai salah satu metode analisis yang paling baik, ini dikarenakan proses analisis sederhana dan instrumen ini banyak digunakan pada sebagian besar laboratorium kontrol kualitas.…”

Section: Pendahuluanunclassified

ANALISIS KUALITATIF & KUANTITATIF KANDUNGAN ASAM SALISILAT PADA SEDIAAN KOSMETIKA SEMI PADAT YANG BEREDAR DI PASAR BERINGHARJO, YOGYAKARTA

Fatmawati

2023

INPHARNMED

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Sediaan kosmetika yang diaplikasikan pada wajah dapat mempengaruhi struktur kulit dan penampilan. Bahan yang ditambahkan pada sediaan kosmetika untuk memperbaiki penampilan wajah salah satunya yaitu senyawa asam salisilat, zat anti acne & keratolitik. Penelitian ini bertujuan untuk melakukan analisis kualitatif dan kuantitatif senyawa asam salisilat dalam sediaan semi padat. Sampel yang digunakan pada penelitian ini berasal dari Pasar Beringharjo Yogyakarta, dengan kriteria berupa sediaan semi padat yang dapat diaplikasikan pada wajah. Sampel A merupakan sediaan gel anti acne dengan hasil positif mengandung asam salisilat dan dilakukan penetapan kadar. Sedangkan sampel B (cream antibakteri & antijamur) dan sampel C (cream foundation), tidak mengandung asam salisilat. Persamaan regresi linier standar asam salisilat Y=0,0114X+0,0911 dengan nilai linieritas R=0,9963 dan LOD 5,186 ppm serta LOQ 15,714 ppm. Hasil penetapan kadar asam salisilat dalam sampel A yaitu 1,24 ± 0,06 % (b/b). Hal ini menunjukkan bahwa kadar asam salisilat dalam sampel A memenuhi persyaratan Peraturan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia dan the Chinese Hygienic Standard, yaitu tidak lebih dari 2%.

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Section: Pendahuluanunclassified

ANALISIS KUALITATIF & KUANTITATIF KANDUNGAN ASAM SALISILAT PADA SEDIAAN KOSMETIKA SEMI PADAT YANG BEREDAR DI PASAR BERINGHARJO, YOGYAKARTA

Fatmawati

2023

INPHARNMED

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“…For certain businesses, prohibited substances may be added to enhance the effectiveness of short-term cosmetics. Chemical analysis techniques for cosmetic products that have been reported include thin layer chromatography, [4][5][6][7] capillary electrophoresis, 8,9 gas chromatography with flame ionization detection 10,11 or coupled with various types of mass spectrometers, 12 and high-performance liquid chromatography using ultraviolet, [13][14][15][16][17][18][19] electrochemical detection, [20][21][22] or coupled with various types of mass spectrometers. [23][24][25][26][27][28][29] Sample pretreatment for these methods usually requires multiple steps to complete.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of undesired cosmetic ingredients by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Ouyang

Chen

et al. 2017

Eur J Mass Spectrom (Chichester)

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In recent years, cosmetic industry profits soared due to the widespread use of cosmetics, which resulted in illicit manufacturers and products of poor quality. Therefore, the rapid and accurate detection of the composition of cosmetics has become crucial. At present, numerous methods, such as gas chromatography and liquid chromatography-mass spectrometry, were available for the analysis of cosmetic ingredients. However, these methods present several limitations, such as failure to perform comprehensive and rapid analysis of the samples. Compared with other techniques, matrix-assisted laser desorption ionization time-of-flight mass spectrometry offered the advantages of wide detection range, fast speed and high accuracy. In this article, we briefly summarized how to select a suitable matrix and adjust the appropriate laser energy. We also discussed the rapid identification of undesired ingredients, focusing on antibiotics and hormones in cosmetics.

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“…As mentioned above, a number of active ingredients are applied to cosmetics at high levels, and these ingredients can be extracted by a relatively simple approach. For example, the samples were dissolved or diluted with water , buffer solution , ethanol , or ethyl acetate before analyzing ingredients, including fragrances , phthalates , thioglycolic acid , and preservatives . Without a doubt, there are matrix interferences in the measurement due to a lack of clean‐up steps.…”

Section: Introductionmentioning

confidence: 99%

Current trends in sample preparation for cosmetic analysis

Zhong

2016

J of Separation Science

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The widespread applications of cosmetics in modern life make their analysis particularly important from a safety point of view. There is a wide variety of restricted ingredients and prohibited substances that primarily influence the safety of cosmetics. Sample preparation for cosmetic analysis is a crucial step as the complex matrices may seriously interfere with the determination of target analytes. In this review, some new developments (2010-2016) in sample preparation techniques for cosmetic analysis, including liquid-phase microextraction, solid-phase microextraction, matrix solid-phase dispersion, pressurized liquid extraction, cloud point extraction, ultrasound-assisted extraction, and microwave digestion, are presented. Furthermore, the research and progress in sample preparation techniques and their applications in the separation and purification of allowed ingredients and prohibited substances are reviewed.

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Screening of preservatives by HPLC-PDA-ESI/MS: A focus on both allowed and recently forbidden compounds in the new EU cosmetics regulation

Cited by 17 publications

References 16 publications

ANALISIS KUALITATIF & KUANTITATIF KANDUNGAN ASAM SALISILAT PADA SEDIAAN KOSMETIKA SEMI PADAT YANG BEREDAR DI PASAR BERINGHARJO, YOGYAKARTA

ANALISIS KUALITATIF & KUANTITATIF KANDUNGAN ASAM SALISILAT PADA SEDIAAN KOSMETIKA SEMI PADAT YANG BEREDAR DI PASAR BERINGHARJO, YOGYAKARTA

Rapid detection of undesired cosmetic ingredients by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Current trends in sample preparation for cosmetic analysis

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