Screening of Plumbago Species for the Bio-active Marker Plumbagin

Mallavadhani, Uppuluri Venkata; Sahu, Gayatri; Muralidhar, J.

doi:10.1076/phbi.40.7.508.14685

Cited by 52 publications

(27 citation statements)

References 4 publications

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“…In general, the root parts are the rich sources of plumbagin. Interestingly, Plumbago rosea has been found to accumulate maximum plumbagin in the roots while, Plumbago auriculata and Plumbago zeylanica are high yielding species for the leaf and stem parts, respectively (Mallavadhani et al 2002).…”

Section: Plumbaginmentioning

confidence: 99%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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Nutraceuticals from natural sources have been investigated for their putative chemopreventive and cancer therapeutic properties for the last few decades. The interest in these compounds is in part due to their pleiotropic effects and relatively non-toxic nature. A large number of such nutraceuticals are under detailed investigations worldwide but most of them suffer from the lack of sufficient bioavailability in humans. The identification and characterization of novel natural compounds with sufficient anticancer potential is therefore an ongoing process. This article is a summary of anticancer activity of three such novel nutraceuticals, namely garcinol, plumbagin and mangiferin. These compounds have shown promising biological activity in preliminary studies by targeting multiple signaling pathways. In particular, it seems that the inhibition of NF-κB pathway is one of the major mechanism through which these compounds exhibit their anticancer and apoptosis-inducing effects. The data on their anticancer activity is just emerging and the information on their bioavailability is still insufficient to predict their future application in the clinical settings. In this article, we have surveyed the available literature to summarize the mechanisms of anticancer activity of these three novel nutraceuticals. We also discuss the challenges and possible solutions to realize the dream on the translational potential of these compounds into clinical practice for the prevention and/or treatment of human malignancies.

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Section: Plumbaginmentioning

confidence: 99%

Role of Novel Nutraceuticals Garcinol, Plumbagin and Mangiferin in the Prevention and Therapy of Human Malignancies: Mechanisms of Anticancer Activity

Ahmad

Padhyé

Sarkar

2011

Nutraceuticals and Cancer

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“…Plumbago indica is an important traditional medicinal plant and the richest known natural source of plumbagin, a naturally occurring organic compound isolated from the roots of P. indica (Mallavadhani et al 2002). Plumbagin has been reported to have antitumor (Hazra et al 2008), antimicrobial (Didry et al 1994), anticancer (Kuo et al 2006), and antifertility (Bhargava 1984) properties.…”

Section: Introductionmentioning

confidence: 98%

Regeneration of transformed plants from hairy roots of Plumbago indica

Gangopadhyay

Chakraborty

Bhattacharyya

et al. 2010

Plant Cell Tiss Organ Cult

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Spontaneous shoot regeneration was observed from Agrobacterium rhizogenes-induced hairy roots of Plumbago indica when these were incubated in liquid MS medium for a period of 3 weeks under continuous light. Insertion of the rolB gene in putative transformed plants was confirmed by PCR and sequencing. Transformed plants grown for a period of 1 week on solid MS medium containing 0.5 mg l -1 6-benzyladenine and then transplanted to growth regulator-free medium showed better overall growth than control plants. Transformed plants had a higher root bio-biomass and an increased plumbagin content relative to non-transformed plants.

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“…The hydroxy-naphthoquinone, plumbagin is generally extracted from the roots of Plumbago species (Plumbaginaceae), which are used in Indian systems of medicine. Among the species, Plumbago rosea L. is reported to be the best source for harvesting plumbagin (Mallavadhani et al, 2002). Plumbagin is endowed with numerous vital properties such as anticancer, neuroprotective (Luo et al, 2010), tumor angiogenesis inhibition (Lai et al, 2012), prolongevity (Hunt et al, 2011), antibacterial, antifungal (de Paiva et al, 2003, anti-malarial (Likhitwitayawuid et al, 1998), antiviral (Min et al, 2001) and cardiotonic (Itoigawa et al, 1991) activities.…”

Section: Introductionmentioning

confidence: 99%