Screening of Peroxisome Proliferator-activated Receptors (PPARs) α, γ and δ Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-ethnic Malaysian Population

Chia, Phee-Phee; Fan, Sook-Ha; Say, Yee‐How

doi:10.18865/ed.25.4.383

Cited by 14 publications

(9 citation statements)

References 49 publications

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“…Besides, our frequencies differ from those found in Spanish Mediterranean, Brazilian and Croatian populations (Francès et al 2008;Chen et al 2010;Nadalin et al 2014). "VV" genotype was not found in Croatian population (Nadalin et al 2014) and in multi-ethnic Malaysian population (Chia et al 2015). Similarly we found no subjects with "VV" genotype in our control group whereas we found only five subjects in our patient group.…”

Section: Discussioncontrasting

confidence: 96%

PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women

Şirin¹,

Yilmaz-Aydogan²,

Uyar³

et al. 2019

Istanbul J Pharm

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Peroxisome proliferator-activated receptors (PPARs) belong to the superfamily of nuclear receptors which are are ligand-activated transcription factors. Three different PPAR subtypes have been identified; PPARα, PPARβ (also called PPARδ), and PPARγ (Abbot 2009). PPARα is found in tissues such as heart, muscle, liver and kidney where fatty acid catabolism is important and so regulates genes involved in lipid metabolism. PPARα is activated by natural ligands (polyunsaturated fatty acids, lipolytic products of lipoproteins, oxidized phospholipids) and by synthetic ligands (gemfibrozil and fenofibrate) (Touyz and Schiffrin 2006). Fenofibrate which is currently used for the treatment of hypercholesterolemia and hypertriglyceridemia, also maintains bone mass. Whole body and femoral bone mineral density (BMD) values were higher in ovariectomized rats given fenofibrate, compared to controls (Stunes et al. 2011).PPARγ is heavily expressed in adipose tissue and controls adipocyte differentiation and lipid storage. PPARγ regulates the action of insulin through its effects on adipose tissue and skeletal muscle (Touyz and Schiffrin 2006). Natural agonists (eicosanoids and oxidized, polyunsaturated fatty acids) and synthetic agonists (thiazolidinediones; a family of antidiabetic drugs-rosiglitazone and

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Section: Discussioncontrasting

confidence: 96%

PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women

Şirin¹,

Yilmaz-Aydogan²,

Uyar³

et al. 2019

Istanbul J Pharm

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“…In the aspect of pathophysiology of MetS, hyperglycemia is considered as a key factor. Hyperinsulinemia, insulin resistance, and hyperglycemia are increasing proliferation, angiogenesis, damage to the DNA molecule by oxygen active forms due to glucose excess, cellular mobility, and apoptosis 17–19 . From the results of previous literatures, it has been suggested that, MetS affects tumor cells cancer and finally increasing the risk of cancer through the change in insulin receptor expression as well as the activation/inactivation of the growth and transcription factors, their receptors 17,20–22 .…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Incidence of Laryngeal Cancer: A Nationwide Cohort Study

Kim

Han

Joo

2019

Sci Rep

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It is unknown whether the presence of metabolic syndrome (MetS) affects the incidence of laryngeal cancer. The aim of this national population-based retrospective study was to analyze the relationship between MetS and the incidence of laryngeal cancer. Patients with laryngeal cancer (ICD-10: C32) between 2009 and 2010 were retrospectively identified and tracked until 2015 using the Korean Health Insurance claims database. During the seven-year follow-up period, 5,322 subjects were newly diagnosed with larynx cancer. The mean age of people with laryngeal cancer was much higher than those without (63.29 vs. 47.7 years, p < 0.0001), and the incidence of larynx cancer in men was much higher than that in women (93.16% vs. 6.84%, p < 0.0001). Age, gender, smoking status, alcohol intake, and exercise-adjusted hazard ratios indicated that participants with MetS had a 1.13-fold higher hazard of having larynx cancer than those without MetS. The number of MetS components was a strong risk factor for laryngeal cancer with a higher risk estimate of this cancer in both ex- and current smokers as well as people who have never smoked. MetS was found to be an independent risk factor for the incidence of laryngeal cancer. In Korea, MetS and its components are significantly associated with the development of laryngeal cancer.

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“…In the present study, we observed that one MS component hyperglycaemia was independently associated with increased HNC risk. Hyperglycaemia is considered to be a critical factor in the pathophysiology of MS. Hyperglyceamia, Hyperinsulinemia and insulin resistance are increasing proliferation, angiogenesis, and the destruction of DNA molecules by oxygen-active forms caused by excess glucose, cell migration and apoptosis [29][30][31] . Previous studies suggested that MS elevated the incidence risk of cancer through the change of insulin receptors and activation of growth and transcription factors 32,33 .…”

Section: Resultsmentioning

confidence: 99%

The Effect of Metabolic Syndrome on Head and Neck Cancer Incidence Risk: A Population-based Prospective Cohort Study

Jiang

Zhou

et al. 2020

Preprint

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BackgroundThere are limited evidences clarifying the impact of metabolic syndrome (MS) and its components on head and neck cancer (HNC) incidence risk. We explored the correlation between MS, MS components, and the combined effects of MS and C-reactive protein (CRP) and HNC risk. MethodsThis is a prospective analysis of 474,929 participants from the UK Biobank cohort. Cox proportional hazard regression was utilized to assess the hazard ratio (HR) and 95% confidence interval (CI), and to explore the non-linear correlation between an individual MS component and HNC risk. ResultsIndividuals with MS (HR, 1.05; 95%CI, 0.90-1.22) had no higher risk of HNC than those without MS and those with more MS components showed no higher HNC risk. Nevertheless, we observed that MS component hyperglycaemia (HR, 1.22; 95%CI, 1.02-1.45) was independently correlated with elevated HNC risk. In a non-linear manner, waist circumference and high-density lipoprotein (HDL) showed a U-shape association with HNC risk. Further linear analysis indicated that male waist circumference, female waist circumference (when ≥93.16 cm), male HDL (when ≥1.45mmo/L) and blood glucose were positively correlated with HNC risk. Increased CRP (≥1.00mg/dL) elevated HNC risk and individuals with MS and CRP≥ 1.00mg/dL had the highest HNC risk (HR, 1.29; 95%CI, 1.05-1.58). ConclusionsAlthough MS are not correlated with elevated HNC risk, high male waist circumference, high female waist circumference (≥93.16 cm), high male HDL (≥1.45mmo/L) and high blood glucose are independent risk factors of HNC. We also recommended a potential combined effect of MS and CRP in head and neck tumorigenesis.

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Screening of Peroxisome Proliferator-activated Receptors (PPARs) α, γ and δ Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-ethnic Malaysian Population

Cited by 14 publications

References 49 publications

PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women

PPARγ Pro12Ala and C161T polymorphisms, but not PPARα L162V, are associated with osteoporosis risk in Turkish postmenopausal women

Metabolic Syndrome and Incidence of Laryngeal Cancer: A Nationwide Cohort Study

The Effect of Metabolic Syndrome on Head and Neck Cancer Incidence Risk: A Population-based Prospective Cohort Study

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