Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: clinical, genetic and functional studies

Sintas, Cèlia; Carreño, Oriel; Corominas, Roser; Serra, SA; Vila, Magdalena; Fernàndez‐Castillo, Noèlia; Toma, Claudio; Pons, Roser; Llaneza, M.; Sobrido, MJ; Grinberg, Daniel; Valverde, MA; Fernández-Fernández, JM; Macaya, Alfons; Cormand, Bru

doi:10.1186/1129-2377-14-s1-p26

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…The effects of CACNA1A have been interpreted to represent a type of neurological disorder ( 80 ). Variations in the CACNA1A gene have been well documented to result in certain neurological diseases, including familial hemiplegic migraine type 1, sporadic hemiplegic type 1 and spinocerebellar ataxia type 6 ( 81 – 84 ). However, CACNA1A was revealed to be frequently expressed in adenocarcinomas and involved in cell proliferation and differentiation ( 85 , 86 ).…”

Section: Resultsmentioning

confidence: 99%

Voltage-gated calcium channels: Novel targets for cancer therapy

et al. 2017

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Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L-type; R-type; N-type; P/Q-type; and T-type, which are encoded by α1 subunit genes. Calcium ion channels also have confirmed roles in cellular functions, including mitogenesis, proliferation, differentiation, apoptosis and metastasis. An association between VGCCs, a reduction in proliferation and an increase in apoptosis in prostate cancer cells has also been reported. Therefore, in the present study, the online clinical database Oncomine was used to identify the alterations in the mRNA expression level of VGCCs in 19 cancer subtypes. Overall, VGCC family genes exhibited under-expression in numerous types of cancer, including brain, breast, kidney and lung cancers. Notably, the majority of VGCC family members (CACNA1C, CACNA1D, CACNA1A, CACNA1B, CACNA1E, CACNA1H and CACNA1I) exhibited low expression in brain tumors, with mRNA expression levels in the top 1–9% of downregulated gene rankings. A total of 5 VGCC family members (CACNA1A, CACNA1B, CACNA1E, CACNA1G and CACNA1I) were under-expressed in breast cancer, with a gene ranking in the top 1–10% of the low-expressed genes compared with normal tissue. In kidney and lung cancers, CACNA1S, CACNA1C, CACNA1D, CACNA1A and CACNA1H exhibited low expression, with gene rankings in the top 1–8% of downregulated genes. In conclusion, the present findings may contribute to the development of new cancer treatment approaches by identifying target genes involved in specific types of cancer.

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Section: Resultsmentioning

confidence: 99%

Voltage-gated calcium channels: Novel targets for cancer therapy

et al. 2017

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Aberrant DNA Methylation Pattern may Enhance Susceptibility to Migraine: A Novel Perspective

Goel

Nisa

Reza

et al. 2019

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In today’s world, migraine is one of the most frequent disorders with an estimated world prevalence of 14.7% characterized by attacks of a severe headache making people enfeebled and imposing a big socioeconomic burden. The pathophysiology of a migraine is not completely understood however there are pieces of evidence that epigenetics performs a primary role in the pathophysiology of migraine. Here, in this review, we highlight current evidence for an epigenetic link with migraine in particular DNA methylation of numerous genes involved in migraine pathogenesis. Outcomes of various studies have explained the function of DNA methylation of a several migraine related genes such as RAMP1, CALCA, NOS1, ESR1, MTHFR and NR4A3 in migraine pathogenesis. Mentioned data suggested there exist a strong association of DNA methylation of migraine-related genes in migraine. Although we now have a general understanding of the role of epigenetic modifications of a numerous migraine associated genes in migraine pathogenesis, there are many areas of active research are of key relevance to medicine. Future studies into the complexities of epigenetic modifications will bring a new understanding of the mechanisms of migraine processes and open novel approaches towards therapeutic intervention.

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Screening of cacna1a and ATP1A2 genes in hemiplegic migraine: clinical, genetic and functional studies

Cited by 2 publications

References 2 publications

Voltage-gated calcium channels: Novel targets for cancer therapy

Voltage-gated calcium channels: Novel targets for cancer therapy

Aberrant DNA Methylation Pattern may Enhance Susceptibility to Migraine: A Novel Perspective

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