volume 7, issue 11, P986-999 2015
DOI: 10.18632/aging.100845
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Mylène Ferrand, Olivier Kirsh, Audrey Griveau, David Vindrieux, Nadine Martin, Pierre-Antoine Defossez, David Bernard

Abstract: Cellular senescence results in proliferation arrest and acquisition of hallmarks such as the Senescence-Associated Secretory Phenotype (SASP). Senescence is involved in regulating numerous physio-pathological responses, including embryonic development, cancer, and several aging-related diseases. Only a few kinases, centered on the RAS signaling pathway, have been identified as inducing premature senescence. About possible other senescence-regulating kinases and signaling pathways, practically little is known. …

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