ELANOMA HAS BEEN INCREASING IN INCIDENCE ANDmortality in recent decades and represents a substantial public health problem. Because melanoma trends tend to follow a cohort pattern, deaths from melanoma occur at a younger age than most other cancers, and melanoma is among the most common sites of cancer in young adults.1 Early detection is feasible because melanoma is usually visible on the skin surface when in a curable stage. Invasive melanomas excised when less than 0.76 mm in Breslow thickness are about 96% curable.2 However, if melanoma is not removed before it reaches 3.6 mm in thickness, case fatality is greater than 70%.2 Death due to melanoma is a tragedy that should not be occurring so frequently.Admittedly, there is no reliable and precise measure of the magnitude of survival benefit that can be achieved by early detection; no randomized trials have reported on its effectiveness. Nevertheless, clinical experience, expert opinion, and knowledge of the stages of melanoma progression indicate that the potential to substantially reduce melanoma mortality is huge. Furthermore, reports from populations subject to intensive early detection campaigns have associated those campaigns with reduced mortality 3 and suggest that they are cost-effective. 4 These indications are supported by the trend of improved survival among melanoma patients in recent decades, presumably due in large part to early detection efforts.
Procedure for Early Detection: Skin InspectionThe vast majority of melanomas that have not already metastasized are completely asymptomatic, although visible on the skin surface to the naked eye. Early detection requires inspection of the skin. The skin is already being examined by dermatologists, by primary care physicians, by other professionals who provide primary care, and by patients and their families. The question is not whether it is worthwhile for anyone to look at the skin. Rather, the question is whether and how these skin examinations can and should be improved for the purpose of reducing mortality from melanoma.
The Role of DermatologistsDermatologists have the greatest expertise in diagnosis and treatment of skin lesions and have developed their skills during 3 years of residency training and subsequent experience in practice. For high-risk patients, dermatologists are providing cutaneous examinations and are making increasing use of tools, such as photography and in vivo epiluminescence microscopy, which aid in the early detection of melanoma by those with appropriate training. 5,6 High-risk patients, such as those with multiple dysplastic nevi, a history of melanoma, or a significant family history of melanoma, frequently obtain periodic dermatologic surveillance. These surveillance programs generally involve periodic dermatologic examination as well as patient and family education about warning signs and skin self-examination. Studies of patients in these programs have noted that melanomas occurring in enrolled patients are substantially thinner and hence of better prognosis than the me...