Screening for gestational diabetes in low-risk women: effect of maternal age

Abstract

Background Gestational diabetes mellitus (GDM) is on the rise globally and there are various screening guidelines with regard to patients' criteria. Materials and methods We conducted a prospective cross-sectional study to determine the prevalence of GDM amongst low-risk pregnant women above the age of 25 years. A modified glucose tolerance test (MGTT) was performed between 24 and 36 weeks of gestation. Women with GDM were divided into two groups for analysis: age between 25 and 34 years (group A) and above 35 years (group B). They were managed as per hospital protocol and followed-up until delivery. The women's demographic data, treatment and subsequent pregnancy outcomes were analysed. Results The overall prevalence of GDM in our low-risk women was 14%. GDM was less common in the younger age group (25-34 years) in comparison to those aged above 35 years (9.7% vs. 26.3%, p = 0.001). There was a non-significant increase in the induction of labour (IOL) rate amongst those aged below 35 years compared to the older group (46.7 % vs. 38.5%). The insulin requirement in the age group 25-34 years and above 35 years, were 6.7% and 23.1%, respectively. There was no significant difference between both age groups with regard to caesarean delivery, birth weight above the 95th centile and neonatal hypoglycaemia. Conclusion In low-risk women, the prevalence of GDM is significantly lower in those aged less than 35 years. Diagnosing GDM had resulted in the increment of IOL in this group, although with no significant increase in maternal and neonatal morbidity.

Total Nucleated Cell Count and CD34+ Cell is Reduced in Preeclampsia and Gestational Diabetes Mellitus Pregnancies: Viable Affix Criteria for Cord Blood Banking

“…However, the average maternal age for subject with GDM is 30.74 years old. This finding were contradicting with the previous study which reported, women aged 35 years and above are more likely to have GDM (Kalok et al 2018). As expected, systolic and diastolic BP were significantly higher in the PE group compared to the control group (p=<0.0005), and the GDM group (p=<0.0005).…”

Gestational Diabetes in Malaysia: A Systematic Review of Prevalence, Risk Factors and Outcomes

“…Of the 124 items found from the database and internet search, we included 15 publications in the qualitative analysis (Basri et al 2018;Gill et al 2012;Goh et al 2018;Hasbullah et al 2020;Idris et al 2009;Ismail et al 2013Ismail et al , 2011Kalok et al 2018;Kampan et al 2013;Logakodie et al 2018;Muniswaran et al 2017;Nordin et al 2006;Shamsuddin et al 2001;Tan et al 2012Tan et al , 2007. Two publications with low quality score were excluded (lack of information on the patient recruitment and diagnostic method) (Goh et al 2018;Muniswaran et al 2017).…”

“…Two publications with low quality score were excluded (lack of information on the patient recruitment and diagnostic method) (Goh et al 2018;Muniswaran et al 2017). Eleven publications provided prevalence data (Basri et al 2018;Gill et al 2012;Hasbullah et al 2020;Idris et al 2009;Ismail et al 2013Ismail et al , 2011Kalok et al 2018;Logakodie et al 2018;Shamsuddin et al 2001;Tan et al 2012Tan et al , 2007. Four publications provided risk factors data (Gill et al 2012;Shamsuddin et al 2001;Tan et al 2012Tan et al , 2007, and seven publications provided maternal, foetal/neonatal complications data (Basri et al 2018;Ismail et al 2013Ismail et al , 2011Kalok et al 2018;Kampan et al 2013;Logakodie et al 2018;Nordin et al 2006).…”

“…Eleven publications provided data on prevalence of GDM (Table 1) (Basri et al 2018;Gill et al 2012;Hasbullah et al 2020;Idris et al 2009;Ismail et al 2013Ismail et al , 2011Kalok et al 2018;Logakodie et al 2018;Shamsuddin et al 2001;Tan et al 2012Tan et al , 2007. One publication contained two separate datasets of GDM prevalence (Basri et al 2018).…”

The association of body composition with the risk of gestational diabetes mellitus in Chinese pregnant women

“…However, pregnant women without these risk factors may also develop GDM. Kalok et al [7] conducted a prospective cross-sectional study among low GDM risk pregnant women above the age of 25 years in Malaysia and found the incidence of GDM was 14% in this population. Unfortunately, there is few methods to screen potential GDM in pregnant women with low GDM risk.…”