Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: The role of risk factors and threshold value for the 50‐g glucose challenge test

Tan, Peng Chiong; Ling, Liza Ping; Omar, Siti Zawiah

doi:10.1111/j.1479-828x.2007.00717.x

Cited by 28 publications

(18 citation statements)

References 16 publications

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“…Accordingly, our unselected population of pregnant women should be classified to the high GDM prevalence group (10.9%). This result is comparable with the studies published from Asian developing countries, including Bangladesh (9.6%), Malaysia (11.4%) and India (13.9%) (7, 14, 15). South Asian ethnic origin was observed as an independent risk of GDM and type 2 diabetes development (16, 17).…”

Section: Discussionsupporting

confidence: 88%

Prevalence of Gestational Diabetes in the Southern Part of Bosnia and Herzegovina

Tomić

Mišić

et al. 2016

Mater Sociomed

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Background:The prevalence of gestational diabetes mellitus (GDM), as a complex problem in pregnancy, is increasing all over the world, but most noticeable in developing countries.Aims:To estimate GDM prevalence and associated pregnancy features in the southern part of Bosnia and Herzegovina.Methods:A cross-sectional observational study was conducted from October 2010 through March 2011. A total of 285 pregnant women with singleton pregnancies participated and were asigned to the study in the order they came for their usual ante-natal clinic examination. They underwent an oral glucose tolerance test (OGTT) with 75 g of glucose. Information on OGTT results, maternal characteristics and pregnancy outcomes were collected from database and medical records.Results:Prevalence of GDM was 10.9% according to 1999 World Health Organisation (WHO) diagnostic criteria. Prenatal cigarette smoking, previous GDM, cesarean delivery rate and neonatal hypoglycemia were significantly more frequent in the GDM group compared to the group of pregnancies with normal glucose tolerance (p = 0.015, p < 0.001, p = 0.015, p = 0.002).Conclusion:This study presents a relatively high prevalence of GDM in Bosnia and Herzegovina. There is a need for large well-designed study on GDM prevalence and its other features.

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Section: Discussionsupporting

confidence: 88%

Prevalence of Gestational Diabetes in the Southern Part of Bosnia and Herzegovina

Tomić

Mišić

et al. 2016

Mater Sociomed

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“…Using the WHO 1999 criteria, a prevalence of 7.2 % was reported in Sri Lanka [15], 9.7 % in Bangladesh [17], 11.4 % in Malaysia [18], 20.6 % in United Arab Emirates [19] and 16.3 % in Qatar [20]. Table 4 summarizes the prevalence of GDM reported in some of the recent studies conducted worldwide [21–28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Gestational Diabetes Mellitus in urban and rural Tamil Nadu using IADPSG and WHO 1999 criteria (WINGS 6)

Bhavadharini

Mahalakshmi

Anjana

et al. 2016

Clin Diabetes Endocrinol

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BackgroundTo determine the prevalence of Gestational Diabetes Mellitus (GDM) in urban and rural Tamil Nadu in southern India, using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) and the World Health Organization (WHO) 1999 criteria for GDM.MethodsA total of 2121 pregnant women were screened for GDM from antenatal clinics in government primary health centres of Kancheepuram district (n = 520) and private maternity centres in Chennai city in Tamil Nadu (n = 1601) between January 2013 to December 2014. Oral glucose tolerance tests (OGTT) were done after an overnight fast of at least 8 h, using a 75 g glucose load and venous samples were drawn at 0, 1 and 2 h. GDM was diagnosed using both the IADPSG criteria as well as the WHO 1999 criteria for GDM.ResultsThe overall prevalence of GDM after adjusting for age, BMI, family history of diabetes and previous history of GDM was 18.5 % by IADPSG criteria with no significant urban/rural differences (urban 19.8 % vs rural 16.1 %, p = 0.46). Using the WHO 1999 criteria, the overall adjusted prevalence of GDM was 14.6 % again with no significant urban/rural differences (urban 15.9 % vs rural 8.9 %, p = 0.13).ConclusionThe prevalence of GDM by IADPSG was high both using IADPSG as well as WHO 1999 criteria with no significant urban/rural differences. This emphasizes the need for increasing awareness about GDM and for prevention of GDM in developing countries like India.Electronic supplementary materialThe online version of this article (doi:10.1186/s40842-016-0028-6) contains supplementary material, which is available to authorized users.

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“…4,[9][10][11] On the other hand, there is also conflicting data indicating the lack of an association between Tg and neonatal anthropometrics. 12,13 Despite the higher prevalence of GDM in Asian countries, in comparison with Western countries, 14,15 less is known of these associations during pregnancy in Asians. The strength of correlation and thresholds for risk in Asian mothers may differ given that visceral adiposity/insulin resistance in Asians is elevated at a lower BMI compared with white women.…”

Section: Introductionmentioning

confidence: 99%

Maternal lipids are associated with newborn adiposity, independent of GDM status, obesity and insulin resistance: a prospective observational cohort study

Samsuddin

Arumugam

Amin

et al. 2019

BJOG

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Objective To determine the association between maternal lipaemia and neonatal anthropometrics in Malaysian mother-offspring pairs. Design Prospective observational cohort study.Setting Single tertiary multidisciplinary antenatal clinic in Malaysia.Population A total of 507 mothers: 145 with gestational diabetes mellitus (GDM); 94 who were obese with normal glucose tolerance (NGT) (pre-gravid body mass index, BMI ≥ 27.5 kg/m 2 ), and 268 who were not obese with NGT.Methods Maternal demographic, anthropometric, and clinical data were collected during an interview/examination using a structured questionnaire. Blood was drawn for insulin, C-peptide, triglyceride (Tg), and non-esterified fatty acid (NEFA) during the 75-g 2-hour oral glucose tolerance test (OGTT) screening, and again at 36 weeks of gestation. At birth, neonatal anthropometrics were assessed and data such as gestational weight gain (GWG) were extracted from the records.Main outcome measures Macrosomia, large-for-gestational-age (LGA) status, cohort-specific birthweight (BW), neonatal fat mass (NFM), and sum of skinfold thickness (SSFT) > 90th centile.Results Fasting Tg > 95th centile (3.6 mmol/L) at screening for OGTT was independently associated with LGA (adjusted odds ratio, aOR 10.82, 95% CI 1.26-93.37) after adjustment for maternal glucose, pre-gravid BMI, and insulin sensitivity. Fasting glucose was independently associated with a birthweight ratio (BWR) of >90th centile (aOR 2.06, 95% CI 1.17-3.64), but not with LGA status, in this well-treated GDM cohort with predelivery HbA1c of 5.27%. In all, 45% of mothers had a pre-gravid BMI of <23 kg/m 2 and 61% had a pre-gravid BMI of ≤ 25 kg/m 2 , yet a GWG of >10 kg was associated with a 4.25-fold risk (95% CI 1.71-10.53) of BWR > 90th centile.Conclusion Maternal lipaemia and GWG at a low threshold (>10 kg) adversely impact neonatal adiposity in Asian offspring, independent of glucose, insulin resistance and pre-gravid BMI. These may therefore be important modifiable metabolic targets in pregnancy.

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Screening for gestational diabetes at antenatal booking in a Malaysian university hospital: The role of risk factors and threshold value for the 50‐g glucose challenge test

Abstract: Risk factors were not independent predictors of GDM in women with GCT >or= 7.2 mmol/L. GCT threshold value >or= 7.6 mmol is appropriate for the Malaysian population at high risk of GDM.

Cited by 28 publications

References 16 publications

Prevalence of Gestational Diabetes in the Southern Part of Bosnia and Herzegovina

Prevalence of Gestational Diabetes in the Southern Part of Bosnia and Herzegovina

Prevalence of Gestational Diabetes Mellitus in urban and rural Tamil Nadu using IADPSG and WHO 1999 criteria (WINGS 6)

Maternal lipids are associated with newborn adiposity, independent of GDM status, obesity and insulin resistance: a prospective observational cohort study

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